1. Ultrastructural basis of acute left ventricular failure from severe acute aortic stenosis in the rabbit
- Author
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Vincenzo Mavilla, Visioli O, Tedeschi F, L Vitali-Mazza, Piero Anversa, and Romano Mastandrea
- Subjects
medicine.medical_specialty ,Cardiac Volume ,Heart Ventricles ,Hemodynamics ,Blood Pressure ,Sarcomere ,Constriction ,Contractility ,Myofibrils ,medicine.artery ,Internal medicine ,Medicine ,Animals ,Molecular Biology ,Heart Failure ,Aorta ,business.industry ,Myocardium ,Aortic Valve Stenosis ,medicine.disease ,Mitochondria, Muscle ,Stenosis ,cardiovascular system ,Ventricular pressure ,Cardiology ,Rabbits ,Cardiology and Cardiovascular Medicine ,business ,Myofibril - Abstract
The haemodynamic and morphological data of experimental left ventricular failure due to acute aortic constriction in the rabbit have been studied. A progressive decrease of contractility is preceded by an initial transitory increase in contractility. The sarcomere length/filling pressure curve demonstrates that after constriction of the aorta a decrease in passive extensibility of sarcomeres occurs despite the fact that the ventricular volume is significantly increased in animals with aortic stenosis. Variation in passive lengthening of myofibres, myofibrillar degeneration including fragmentation of Z lines and mitochondrial alterations are the most important morphological changes observed.
- Published
- 1972