1. Conformational changes at membranes of target cells induced by the peptide hormone angiotensin. A spin label study
- Author
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M.M. Oliveira, Antonio C.M. Paiva, S. Schreier-Muccillo, G.X. Niculitcheff, S. Shimuta, Universidade de São Paulo (USP), FAC MED SANTA CASA, and Universidade Federal de São Paulo (UNIFESP)
- Subjects
Guinea Pigs ,Molecular Conformation ,Biophysics ,Receptors, Cell Surface ,Peptide hormone ,Tritium ,Models, Biological ,Biochemistry ,Structure-Activity Relationship ,Smooth muscle ,Ileum ,Structural Biology ,Renin–angiotensin system ,Genetics ,medicine ,Animals ,Guinea pig ileum ,Spin label ,Molecular Biology ,Binding Sites ,Chemistry ,Angiotensin II ,Cell Membrane ,Electron Spin Resonance Spectroscopy ,Membranes, Artificial ,Muscle, Smooth ,Cell Biology ,Lipids ,Kinetics ,Membrane ,Mechanism of action ,Spin Labels ,sense organs ,medicine.symptom ,Protein Binding ,Hormone - Abstract
The mechanism of action of many hormones is thought to be based on the interaction between the hormone and the membranes of target cells. We have examined the interaction of AII** with membranes from smooth muscle of guinea pig ileum [l] through binding studies with the radioactive hormone and monitoring of conformational changes at the membranes with the spin label technique [2,3]. 2.
- Published
- 1974
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