1. Mechanism of action of propazine, a compound of the symmetrical triazine group, in vivo
- Author
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V. G. Bebeshko, G. A. Rodionov, L. I. Kuznetsova, and É. M. Semencheva
- Subjects
chemistry.chemical_compound ,chemistry ,Mechanism of action ,Folic acid ,Stereochemistry ,In vivo ,medicine ,General Medicine ,medicine.symptom ,General Biochemistry, Genetics and Molecular Biology ,Thymine ,Triazine - Abstract
Der iva t ives of the s y m m e t r i c a l t r i az ines can act as folic acid antagonis ts [19]. The abili ty of such antagonis ts to induce " thymine s tarvat ion" has been descr ibed [12]. A typical f ea tu re of folic acid def ic iency in the body is a d is turbance of nucleic acid me tabo l i sm [18]. Folic acid antagonis ts a re c lassed as exogenous et iological f ac to r s in the development of hypoplast ic and ap las t ic anemias [3]. Toxicoa l le rg ic ( immunoaggress ive) blood d i s ea se s a re included by the authors under the same heading. Fol ic acid av i taminos is is accompanied by g loss i t i s , s tomat i t i s , u lcera t ive gas t r i t i s , and enterocol i t i s [14].
- Published
- 1972