1. Effects of lesions in the dorsal or ventral striatum on locomotor activity and on locomotor effects of amphetamine
- Author
-
Sebastian P. Grossman, Darryl B. Neill, and Joseph F. Ross
- Subjects
Dorsum ,Male ,medicine.medical_specialty ,Time Factors ,Adult male ,Light ,medicine.medical_treatment ,Clinical Biochemistry ,Striatum ,Motor Activity ,Toxicology ,Biochemistry ,Locomotor activity ,Stereotaxic Techniques ,Behavioral Neuroscience ,Internal medicine ,medicine ,Animals ,Amphetamine ,Biological Psychiatry ,Pharmacology ,Dose-Response Relationship, Drug ,business.industry ,musculoskeletal, neural, and ocular physiology ,Ventral striatum ,technology, industry, and agriculture ,Darkness ,Corpus Striatum ,Rats ,Stimulant ,Endocrinology ,medicine.anatomical_structure ,Organ Specificity ,Stereotaxic technique ,behavior and behavior mechanisms ,business ,human activities ,Neuroscience ,psychological phenomena and processes ,Injections, Intraperitoneal ,medicine.drug - Abstract
Bilateral electrolytic lesions in the dorsal portion of the anterior striatum of adult male rats reliably increased spontaneous wheel running, and potentiated the stimulant effects of d,1-amphetamine on activity in both running wheels and stabilimeters. Comparable lesions in the ventral aspects of the striatum produced a decrease in spontaneous wheel running and did not modify the activating effects of amphetamine in either wheels or stabilimeters.
- Published
- 1974