1. Hyperglycemia and inhibition of insulin secretion by 2-deoxy-d-glucose in rats with hypothalamic lesions
- Author
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G. Udeschini, A. Pecile, E. E. Müller, Daniela Cocchi, Vincenzo R. Olgiati, and Alberto E. Panerai
- Subjects
Blood Glucose ,medicine.medical_specialty ,Time Factors ,medicine.medical_treatment ,Hypothalamus ,Deoxyglucose ,chemistry.chemical_compound ,Eating ,Internal medicine ,Deoxy Sugars ,medicine ,Animals ,Insulin ,Secretion ,Insulin secretion ,Pharmacology ,business.industry ,Peripheral ,Rats ,Endocrinology ,Threshold dose ,chemistry ,Depression, Chemical ,Blood glucose ,insulin ,hypothalamus ,Systemic administration ,Female ,2-Deoxy-D-glucose ,business - Abstract
Summary Glucoprivation effects on blood glucose (BG) and insulin (I) secretion have been investigated in rats bearing electrolytic lesions in the hypothalamic glucoreceptor areas. Systemic administration of 2-deoxy-D-glucose (2-DG) to rats bilaterally lesioned 24–48 hr before in the ventromedial (VMH) or/and ventrolateral (LHA) hypothalamus induced a BG rise and inhibition of rise in plasma I levels not dissimilar from those elicited in sham-operated rats. The threshold dose for 2-DG effects (60 mg/kg) was the same for VMH-LHA lesioned rats and sham-operated controls. These results suggest the existence of peripheral glucoreceptors for the hyperglycemic and insulin inhibiting effects of 2-DG but do not exclude the presence in the brain of other glucosensitive areas besides the VMH and LHA.
- Published
- 1975