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This article informs that the graft-versus-host reaction (GvHR) in the chicken embryo appears to result from an interaction between thymus-dependent (T) lymphocytes in the donor inoculum and elements of the host's blood forming system. If chicken embryos are inoculated with allogeneic blood at an early stage of development, before stem cells have migrated from the yolk sac, proliferative lesions, such as poeks in the chorioallantoic membrane, do not occur. This appears to prevent the subsequent migration of these cells into the various intra-embryonic haemopoietic organs resulting in lymphoid aplasia.

This article discusses the pathogenesis of graft-versus-host reaction in chicken embryos. Descriptions of the graft-versus-host reaction in the chicken embryo stress the development of proliferative lesions in various intra-embryonic haemopoietic tissues and in the chorio-allantoic membrane. An examination of the levels of some lysosomal enzymes in the circulating blood was carried out, since tissue injury is frequently accompanied by release of lysosomal enzymes into the tissue fluids. In normal chicken embryos excessive blood loss from minor breaches of the vessel wall is usually prevented by the formation of a thrombocyte plug.

Cites a study conducted by researchers in Australia which examines the effect of a graft-versus-host reaction (GvHR) on the development of the yolk sac, bursa of Fabricius, thymus and bone marrow. Depletion of stem cells in the haemopoietic tissue of the yolk; Development and maturation of haemopoietic tissues; Nature of a GvHR in chicken embryos.

This article presents a study of the influence of embryo age on the expression of the Graft-versus-Host (GvH) reaction in the chicken embryo. Descriptions of pathological manifestations of the GvH reaction produced by adult lymphoid cells in allergenic chicken embryos are confined primarily to proliferative changes in the haemopoietic anlagen of the recipient. Although the developing spleen does not receive an arterial supply until around the 12th day of incubation, it is connected to the vascular circuit from its earliest stage of development by a branch of the omphalomesenteric vein.