1. Ultrastructural changes in the cerebrovascular endothelium induced by a diet high in linoleic acid and deficient in vitamin E
- Author
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Paul A. Young, Mang C. Yu, and Wan-hua A. Yu
- Subjects
Cytoplasm ,medicine.medical_specialty ,Time Factors ,Endothelium ,Linoleic acid ,medicine.medical_treatment ,Clinical Biochemistry ,Biology ,Pathology and Forensic Medicine ,Lipid peroxidation ,Pathogenesis ,chemistry.chemical_compound ,Cerebellum ,Internal medicine ,medicine ,Animals ,Vitamin E Deficiency ,Fragmentation (cell biology) ,Molecular Biology ,Unsaturated fatty acid ,Vitamin E ,Brain ,Dietary Fats ,Capillaries ,Endocrinology ,medicine.anatomical_structure ,Linoleic Acids ,Biochemistry ,chemistry ,Blood Vessels ,Vitamin E deficiency ,Chickens - Abstract
Studies were made on the blood vessels of the brain of chicks which were fed a diet high in linoleic acid and deficient in vitamin E. Electron microscopic observations revealed that ceroidlike dense bodies began to accumulate in some endothelial cells after 1 wk on the diet. By 2 wk, these dense bodies were found to occupy large segments of the endothelial cytoplasm in many blood vessels. The endothelia of capillaries and venules of the cerebellum in addition, were swollen and underwent fragmentation and denudation with focal breakdown of the vascular wall. The pathogenesis of the vascular injury was discussed in the light of lipid peroxidation as a result of excess uptake of unsaturated fatty acid with the absence of vitamin E.
- Published
- 1974
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