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The hexobarbital concentration in the brain of mice in relation to sleeping time, velocity of elimination and body temperature was studied: 1. When the hexobarbital dose was plotted against the sleeping time at room temperature (both in logarithmic scale) a straight line was obtained. A change in elimination constant or sensitivity produced a parallel shifting of this line. 2. The hexobarbital concentration in brain (logarithmic scale) plotted against time (linear scale) gave a straight line at 37°C and a curve (2nd degree) at 21°C environmental temperature. 3. Sleeping time, hexobarbital concentration in brain at awakening, elimination constant and liver weight were distributed lognormally. 4. At 21°C the sleeping time was longer and the hexobarbital concentration in brain at awakening lower compared with the results obtained at 37°C. 5. After increasing hexobarbital doses at 37°C a higher and at 21°C a lower hexobarbital concentration in brain at awakening were observed. This effect can be due to a change in sensitivity. 6. At room temperature there was a fall of body temperature under hexobarbital anesthesia, followed by a slight rise without reaching the level at beginning. The fall of temperature during the first 90 minutes is explained by physical temperature loss. 7. A pretreatment with chlorpromazine prolonged the hexobarbital sleeping time at 37°C. The lowered hexobarbital concentration in brain at awakening is probably due to a higher sensitivity against hexobarbital.

Background Youth is a vulnerable group for developing almost all life-style related diseases. The present cross-sectional study was conducted to assess the determinants of blood pressure among entry year students in a medical university in Ajman, United Arab Emirates. Materials and Methods One hundred and ten students from Gulf Medical University, Ajman, UAE participated in the study. A pretested structured questionnaire was used for data collection. Predictive Analytic Software 17 was used for data analysis. Chi-square test, Univariate and multivariate logistic regression were used. Results Variables such as tobacco use, duration of sleep, Body Mass Index and gender were considered to assess the association with blood pressure. The mean age of the students was 19 years with a SD of 1.9 years. The mean systolic and diastolic blood pressure was 113.5 (SD 12.0) and 73.7 (SD 11.2) respectively with mean BMI of 24.9 (SD 5.7). A statistically significant association was observed between gender and blood pressure (p

Studies have been carried out during induction of anaesthesia to relate the dose of propanidid to the duration of sleep. It was found that there was an almost linear relationship though the duration did not continue to increase in proportion to the dose. This differs from the expected relationship with thiopentone and seems to agree with the concept that propanidid is rapidly broken down in the blood stream.

An exploratory study was conducted to investigate the influence of various durations of sleep on dream recall and content. Ten Ss reported dreams on 5 mornings, separated by 5-day intervals, following 5, 61/2, 8, 91/2, and 11 h of nocturnal sleep. The total number of dreams reported subsequent to extended sleep (91/2 and 11 h) was significantly higher than the number reported after sleep deprivation (5 and 61/2 h) and 8 h of sleep (p