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Endocrine disrupting chemicals or carcinogens have been known for decades for their endocrine signal disruption. Endocrine disrupting chemicals are a serious concern and they have been included in the top priority toxicants and persistent organic pollutants. Therefore, researchers have been working for a long time to understand their mechanisms of interaction in different human organs. Several reports are available about the carcinogen potential of these chemicals. The presented review is an endeavor to understand the hazard identification associated with endocrine disrupting carcinogens in relation to the human body. The paper discusses the major endocrine disrupting carcinogens and their potency for carcinogenesis. It discusses human exposure, route of entry, carcinogenicity and mechanisms. In addition, the paper discusses the research gaps and bottlenecks associated with the research. Moreover, it discusses the limitations associated with the analytical techniques for detection of endocrine disrupting carcinogens. [Display omitted] • Types of endocrine disrupting chemicals (EDCs) related to cancer were analyzed. • EDCs associated cancers and their mechanisms were discussed. • Human exposure to EDCs was explored. • Assessment of EDCs carcinogenicity was performed. • Research gaps and future studies were suggested. [ABSTRACT FROM AUTHOR]

Sucralose, a sugar substitute first approved for use in 1991, is a non-caloric sweetener regulated globally as a food additive. Based on numerous experimental animal studies (dating to the 1980s) and human epidemiology studies, international health agencies have determined that sucralose is safe when consumed as intended. A single lifetime rodent carcinogenicity bioassay conducted by the Ramazzini Institute (RI) reported that mice fed diets containing sucralose develop hematopoietic neoplasia, but controversy continues regarding the validity and relevance of these data for predicting health effects in humans. The present paper addresses the controversy by providing the perspective of experienced pathologists on sucralose-related animal toxicity and carcinogenicity data generally, and the RI carcinogenicity bioassay findings specifically, using results from publicly available papers and international regulatory authority decisions. In the authors' view, flaws in the design, methodology, data evaluation, and reporting of the RI carcinogenicity bioassay for sucralose diminish the value of the data as evidence that this agent represents a carcinogenic hazard to humans. This limitation will remain until the RI bioassay is repeated under Good Laboratory Practices and the design, data, and accuracy of the pathology diagnoses and interpretations are reviewed by qualified pathologists with experience in evaluating potential chemically-induced carcinogenic hazards. [ABSTRACT FROM AUTHOR]

Crane-related accidents often occur due to failure in timely and accurate hazard identification. Virtual Reality (VR) technology facilitates immersive environments for improving hazard identification without real-world consequences. However, the impact of simulation fidelity on hazard identification performance, particularly for novice crane operators, remains underexplored. This paper examines how simulation fidelity and task complexity affect hazard identification performance among novice operators through a VR experiment with two fidelity and two complexity levels. Findings demonstrate high-fidelity (HF) scenarios significantly improve hazard identification success rate and speed for swing-over hazards but extend task completion times. Task complexity modulates simulation fidelity's impact on task completion, with significant differences between fidelity levels observed only under low complexity. These insights inform the design and calibration of simulation fidelity in VR platforms, potentially improving training efficacy and crane lifting safety for novice operators. • Explores the impact of simulation fidelity on novice crane operators' hazard identification. • Finds that high-fidelity boosts success rate but reduces speed in hazard identification. • Highlights accuracy-speed trade-off due to simulation fidelity changes. • Emphasises interaction fidelity for immersive, real-world-like experiences. • Guides on balancing simulation fidelity and cost-effectiveness in VR safety training. [ABSTRACT FROM AUTHOR]