1. The anti-inflammatory effects of antidepressants on colitis.
- Author
-
Khazraei, Hajar and Shamsdin, Seyedeh Azra
- Subjects
- *
INFLAMMATION prevention , *COLITIS , *ACETIC acid , *RESEARCH funding , *ENZYME-linked immunosorbent assay , *SEROTONIN uptake inhibitors , *CLOMIPRAMINE , *RISPERIDONE , *ULCERATIVE colitis , *TREATMENT effectiveness , *PREDNISOLONE , *ANTIDEPRESSANTS , *RATS , *ANIMAL experimentation , *DRUG efficacy , *CITALOPRAM , *MENTAL depression , *TUMOR necrosis factors , *INTERLEUKINS - Abstract
Aim: Clomipramine (tricyclic antidepressant), Risperidone (a non-typical antidepressant), and Escitalopram (selective serotonin reuptake inhibitor antidepressant) might be good candidates for investigating the anti-colitis activity. Background: The incidence of depression with ulcerative colitis in patients has led to the use of antidepressants in their treatment. In addition to the antidepressant effect of these drugs, anti-inflammatory effects have also been reported. Methods: In this study, 36 rats were used 2 ml of 3% acetic acid solution rectally to show the colitis. Then, Clomipramine (25 mg/kg), Escitalopram (10 mg/kg), Prednisolone (5 mg/kg), Risperidone (2 mg/kg), and normal saline as the control was administered orally for six days. The levels of Tumor Necrosis factor-alpha (TNF-α), Interleukin-6 (IL-6), and myeloperoxidase (MPO) were measured by Enzyme-linked immune sorbent assay (ELISA), and changes in the tissue pathology were investigated. Results: IL-6 level was significantly reduced after the administration of clomipramine and Prednisolone (p=0.025). Risperidone has significantly reduced MPO activity in colonic tissue (P=0.006). We did find no statistical decrease in MPO activity and TNF-α and IL-6 levels after consumption of Escitalopram (p>0.05). Conclusion: Clomipramine showed the best anti-inflammatory effect compared to Escitalopram and Risperidone. Therefore, clomipramine showed the best relieving effect on inflammation of ulcerative colitis in rats. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF