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This article discusses the use of HaemoCer PLUS, a hemostatic powder, in the treatment and prevention of lower gastrointestinal (GI) bleeding after endoscopic resectional procedures. GI bleeding is a common complication of these procedures, and current treatments include injection therapy, mechanical therapy, and thermal therapy. The study aims to establish a multicenter registry to collect data on the use of HaemoCer PLUS for the prevention of delayed bleeding after colonic endoscopic resectional procedures. Preliminary results suggest that HaemoCer PLUS may be an effective additional therapy for preventing bleeding in patients with large colonic endoscopic resections who are on ongoing antiplatelet therapy. However, managing combined antiplatelet and anticoagulant therapy in patients with comorbidities remains challenging. [Extracted from the article]

This article discusses a prospective observational study that evaluated the feasibility and effectiveness of a novel self-assembling peptide hemostatic gel for initial hemostasis in endoscopic sphincterotomy-related hemorrhage. The study included 202 patients who underwent endoscopic sphincterotomy, with 20 patients experiencing bleeding and receiving the hemostatic gel. The results showed that the application of the hemostatic gel was a safe and effective method for achieving hemostasis in these cases. The study suggests that the hemostatic gel may be a viable option for initial hemostasis in endoscopic sphincterotomy-related bleeding. [Extracted from the article]

This article, published in the journal Endoscopy, explores the risk factors associated with delayed post polypectomy bleeding, which is a common complication of endoscopic polypectomy. The study suggests that endoscopic hemostasis is usually not necessary for low-risk stigmata, such as flat pigmented stigma or a clean base. However, for high-risk stigmata, such as active bleeding or visible vessels, endoscopic hemostasis may be warranted. The study also highlights potential risk factors for high-risk stigmata, including hemodynamic instability, the need for transfusion, shock index, polyp size, and the use of prophylactic hemostatic clips. The authors conclude that further research is needed to determine which patients with delayed post polypectomy bleeding can be treated conservatively. [Extracted from the article]

This article, published in the journal Endoscopy, compares the clinical and endoscopic features of upper gastrointestinal bleeding (UGI) in young and elderly patients. The study, conducted over a one-year period, included 332 patients admitted to the emergency endoscopy unit for UGI bleeding. The results showed that while older patients had more comorbidities and were more likely to be on antithrombotic therapy, there was no significant difference in the severity of bleeding between the two age groups. The presence of active bleeding was the only factor that predicted the need for endoscopic hemostasis. Overall, the study suggests that UGI bleeding in older patients may not be more severe than in younger patients. [Extracted from the article]

This article discusses the advancements in endoscopic submucosal dissection (ESD) for the treatment of colonic tumors. The authors present a case study using the latest technological developments to simplify the procedure. These innovations include a flexible knife for high-pressure injection, a multipolar adaptive traction device for better exposure, an ergonomic pedal fixator to reduce errors, and red dichromic imaging for early detection of bleeding points. The authors suggest that these new advancements could improve the accessibility and dissemination of ESD, but emphasize the importance of organized and effective training. [Extracted from the article]

This article discusses a case study of a 54-year-old woman who underwent endoscopic submucosal dissection (ESD) for a tumor in the rectum. The ESD procedure resulted in post-operative bleeding, and various techniques were attempted to control the bleeding without success. The Apollo Overstitch suturing system was then used, which effectively achieved immediate and long-lasting bleeding control. The article concludes that this suturing system is a safe and effective option when other methods of endoscopic hemostasis have failed. [Extracted from the article]

This article, titled "A rare case of melena: Ampullary Hemangioma," discusses the case of a 64-year-old female patient who presented to the emergency department with melena (black, tarry stools) and a drop in hemoglobin levels. After resuscitation, a gastroscopy was performed, revealing a smooth atypical hemorrhagic mass protruding from the ampulla. Biopsies were inconclusive, so the option of surgical biopsy and ampullectomy (removal of the ampulla) was offered and chosen by the patient's family. Computed tomography confirmed a 3.5 cm non-metastatic ampullary mass, and the patient underwent successful surgical ampullectomy. The final pathology confirmed the diagnosis of ampullary hemangioma, a rare benign vascular tumor that can cause melena. The article highlights the challenges of endoscopic hemostasis (stopping bleeding) in such rare conditions, which often require surgical resection. [Extracted from the article]

This article presents the preliminary results of a study on colorectal endoscopic submucosal dissection (ESD) procedures. The study included 29 patients with 30 lesions, with the majority of patients being women. The ESD technique was successful in 86.67% of cases, with only one patient experiencing delayed bleeding. The study found that starting colorectal ESD in a single center with a single operator team is feasible and yields good initial results. [Extracted from the article]

This article, published in the journal Endoscopy, examines the clinical efficacy and cost-effectiveness of local hemostatic agents in upper gastrointestinal bleeding (UGIB). The study focuses on the use of bentonite and synthetic peptides as local hemostatic agents and evaluates their effectiveness in achieving immediate endoscopic hemostasis and preventing UGIB recurrence. The retrospective monocenter study includes 274 patients who received these agents at a tertiary center between 2013 and 2023. The results show that both bentonite and synthetic peptides are safe and effective in treating UGIB, with synthetic peptides showing a trend towards lower rates of recurrent UGIB episodes. [Extracted from the article]

This article, published in the journal Endoscopy, compares the clinical and endoscopic features of upper gastrointestinal bleeding (UGI) in young and elderly patients. The study, conducted over a one-year period, included 332 patients admitted to the emergency endoscopy unit for UGI bleeding. The results showed that while older patients had more comorbidities and were more likely to be on antithrombotic therapy, there was no significant difference in the severity of bleeding between the two age groups. The presence of active bleeding was the only factor that predicted the need for endoscopic hemostasis. Overall, the study suggests that UGI bleeding in older patients may not be more severe than in younger patients. [Extracted from the article]

This article compares the clinical, endoscopic, and evolutionary features of patients with upper gastrointestinal hemorrhage (UGI) who are newly admitted to the emergency department (group A) versus those who are already hospitalized (group B). The study included 332 patients and found that 81% of cases presented with community hemorrhage, while 19% had in-hospital hemorrhage. The study found that there were no statistically significant differences in age, sex, or origin of bleeding between the two groups. However, there were significant differences in the presence of comorbidities, use of antithrombotic drugs, presence of active bleeding, use of endoscopic hemostatic procedures, and need for transfusion. The study also found higher transfusion requirements, active bleeding rates, use of endoscopic hemostasis, and mortality for in-hospital bleeding. [Extracted from the article]

This article, published in the journal Endoscopy, compares the efficacy of hemostatic powder (HP) with conventional treatments for malignancy-related upper gastrointestinal bleeding (UGIB). The study analyzed data from 213 patients with UGIB, with 86 patients treated with HP and 127 patients treated with conventional hemostatic treatments. The results showed that HP had a higher initial hemostasis success rate compared to conventional treatments. However, there were no significant differences in terms of blood transfusion, rebleeding rates, length of hospitalization, and 30-day all-cause mortality. The study suggests that HP may be an effective and safe method for managing acute malignancy-related UGIB, but further research is needed. [Extracted from the article]

This article compares the outcomes of endoscopic treatment for nonvariceal upper gastrointestinal hemorrhage (NVUGIH) caused by peptic ulcers (PU) and Dieulafoy's lesions (DL). The study reviewed the endoscopy database of a hospital over a 10-year period and included patients who underwent upper gastrointestinal endoscopies for hematemesis, hematochezia, and melena. The results showed that DL patients had a significantly higher need for endoscopic hemostasis compared to PU patients. Combination therapy was the preferred technique in both groups, and there was no statistically significant difference in terms of persistent or recurrent bleeding between the two groups. [Extracted from the article]

This article discusses the use of endoscopic papillectomy (EP) as a treatment for ampullary lesions (AL) of the minor duodenal papilla. The study identified 20 patients with AL of the minor papilla and compared them to a cohort of 40 patients with AL of the major papilla. The results showed that EP was safe and effective for treating AL of the minor papilla, with comparable rates of complete resection, en bloc resection, and recurrences between the two groups. There were no severe complications reported, although one patient experienced delayed bleeding that was successfully treated. The authors conclude that AL of the minor papilla can be managed according to guidelines for EP of the major papilla. [Extracted from the article]

This article discusses the role of the expert Endoscopy Nurse in performing endoscopic full-thickness resection (EFTR) procedures. The nurse assembles the device and acts as a second operator alongside the endoscopist. The success of the procedure depends on the collaboration between the nurse and the endoscopist. The article presents the results of 46 procedures performed in their Endoscopy Unit, with all cases achieving complete resection. The histological examination revealed various findings, including low grade dysplasia, high grade dysplasia, and adenocarcinoma foci. There were no major complications, and any bleeding was successfully treated. The article concludes that EFTR is a promising technique that can be an alternative to surgery, reducing hospitalization costs. The collaboration between the physician and the experienced Endoscopy Nurse is crucial for the success of the procedure. [Extracted from the article]

This article provides a retrospective evaluation of 224 patients admitted to a tertiary hospital with upper gastrointestinal bleeding (UGIB). The study aimed to characterize the clinical and endoscopic findings, efficacy of hemostasis, duration of hospitalization, and hospital mortality in these patients. The results showed that UGIB was more common in males and that peptic ulcer was the primary cause. Endoscopic hemostasis was effective in most cases, but oncological and chronic respiratory diseases were risk factors for rebleeding. Chronic liver disease, oncological disease, NSAIDs, ICU admission, and alcohol abuse were associated with higher in-patient mortality. [Extracted from the article]