1. Two new sesterterpenoids from Atractylodes japonica Koidz. ex Kitam.
- Author
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Zhou, Yuan-Yuan, Sun, Zhao, Liu, Yan, Fang, Zhen-Xing, Gao, Hui-Rui, Liu, Ning-Yu, Zhang, Xiao-Juan, Yang, Bing-You, and Kuang, Hai-Xue
- Abstract
Two new sesterterpenoids, atractylodes japonica terpenoid acid I (1) and atractylodes japonica terpenoid aldehyde I (2), were isolated from the rhizomes of Atractylodes japonica Koidz. ex Kitam together with ten known compounds (3–12). Their structures were elucidated on the basis of comprehensive spectroscopic analysis (1D/2D NMR, HRESIMS and IR). In addition, all of these isolated compounds were evaluated for their cytotoxic activities against human gastric cancer cell MGC-803 and human hepatocellular cancer cell HepG-2. Most of them exhibited moderate to weak inhibitory effects with IC
50 values in the range of 25.15–88.85 μM except for 9–12. [ABSTRACT FROM AUTHOR]- Published
- 2024
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