Search

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive myeloid malignancy associated with a poor prognosis. Although allogeneic hematopoietic stem cell transplantation (allo-HSCT) has emerged as a potential treatment strategy for BPDCN, standardized conditioning regimens remain lacking. In this manuscript, we present two cases of BPDCN that were treated with a thiotepa-busulfan-fludarabine (TBF)-based conditioning regimen prior to allo-HSCT. Both cases demonstrated complete remission post-transplantation, sustained donor chimerism, and remission maintenance, suggesting the potential efficacy of the TBF conditioning regimen for BPDCN transplantation. Given the small sample size in our study, we emphasize caution and advocate for larger studies to confirm the efficacy of TBF in the treatment of BPDCN. [ABSTRACT FROM AUTHOR]

This letter, published in the Annals of Hematology, reports on a case of a patient with myeloid/lymphoid neoplasm with eosinophilia (MLN-eo) who presented with an osteolytic lesion. The patient experienced progressive osteodynia and was found to have multiple punched-out osteolytic lesions. The patient underwent chemotherapy and achieved bone marrow complete remission, but unfortunately, the osteolytic lesion persisted and the patient eventually died. The study also conducted RNA sequencing and found that osteoclast-related pathways were enriched in the patient's transcriptional profiles. This case highlights the rare occurrence of osteolytic lesions in MLN-eo patients and suggests a potential role of FIP1L1-PDGFRA rearrangement and RUNX1 mutation in causing the osteolytic lesion. [Extracted from the article]

This article presents a case report of a 55-year-old man with diffuse large B-cell lymphoma (DLBCL) involving the heart. The patient initially presented with fever, chest discomfort, and echocardiographic findings of masses in the right atrioventricular wall and reduced left ventricular contractility. Further tests revealed enlarged lymph nodes and multiple soft tissue masses in the pericardium and right atrium. The patient was treated with a modified R-CHOP chemotherapy regimen, which resulted in improved symptoms and a reduction in tumor size. The report emphasizes the rarity of cardiac-dominant DLBCL and the importance of early diagnosis and appropriate treatment. [Extracted from the article]