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Genetics, birth defects, some viral diseases, persistent ear infections, medications, loud noises, and age can all cause hearing loss, a global health issue. The mumps are typically the cause of unilaterally acquired sensorineural hearing loss in children. A hybrid fractional operator model employing Constant Proportional Caputo (CPC), Constant Proportional Caputo Fabrizio (CPCF), and Constant Proportional Atangana-Baleanu Caputo (CPABC) in the Caputo sense is developed to investigate mumps induced hearing loss in children. We focused on the region that is positively invariant and well-posed in the suggested model. We assessed the endemic and disease free equilibrium, reproductive number, strength number, and parameter sensitivity, and examined the global stability of the proposed system. The existence, uniqueness, and Hilfer generalized proportional operators for the constant of proportionality of the system’s solutions are demonstrated using fixed-point theorems. We simulated a system of fractional differential equations analytically using the Laplace Adomian Decomposition Method (LADM). This study is important since it is the first to model mumps related hearing loss using a fractional order model based on hybrid fractional operators without a singular kernel. The fractional-order derivative retains the system memory effect, is nonlocal, and outperforms the integer-order derivative in this regard. This sort of study aids medical professionals in diagnosis, treatment planning, and decision-making for mumps induced hearing loss. [ABSTRACT FROM AUTHOR]