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We studied Korean patients with Eales' disease to document clinical features, long-term outcomes, and explore its association with TB, given South Korea's high TB burden. We retrospectively reviewed medical records of Eales' disease patients for clinical characteristics, long-term outcomes, and its association with TB. Among 106 eyes, the average age of diagnosis was 39.28 years, with 82.7% male and 58.7% having unilateral involvement. Patients who underwent vitrectomy showed greater long-term improvement in visual acuity (P =.047), while those with glaucoma filtration surgery showed less improvement (P =.008). Having glaucoma through disease progression was associated with poor visual outcomes (odds ratio=15.556, P <.02). 27 out of 39 patients (69.23%) who underwent IGRA screening tested positive for TB. In Korean patients with Eales' disease, we observed male predominance, unilateral presentation, older age of onset, and a link with TB. Timely diagnosis and management should be considered to maintain good vision in patients with Eales' disease. [ABSTRACT FROM AUTHOR]

COVID-19 infection and subsequent quarantine experiences during the pandemic may have profoundly affected many aspects of life among COVID-19 survivors. However, limited research has explored the changes these survivors experienced once they returned to their daily lives. This study aimed to explore COVID-19 survivors' psychosocial impacts and their lives following infection and social quarantine during the initial phase of the pandemic in South Korea. Semistructured telephone interviews were conducted in June 2021, involving 15 COVID-19 survivors. All participants contracted COVID-19 between February 2020 and April 2021 in South Korea. This study used a qualitative methodology from phenomelogical perspectives to explore and understand the participants' shared lived experiences. Thematic analysis identified four overarching themes and 12 subthemes among Korean COVID-19 survivors: (a) self-concept transformation; (b) changed relationship dynamics; (c) life perspective shifts; and (d) health awareness evolution. Recognizing the life changes experienced by COVID-19 survivors can inform the development of targeted peer support services and person-centered education. Focusing on health awareness and empowerment, these initiatives can promote personal growth, facilitate positive changes, and alleviate traumatic experiences for future survivors of diverse infectious diseases. Future research could investigate the long-term impact of COVID-19 on individuals' lives and explore the mechanisms underlying these effects. [ABSTRACT FROM AUTHOR]

Background: Accurate identification of fetal growth restriction in fetal autopsy is critical for assessing causes of death. We examined the impact of using a chart derived from ultrasound measurements of healthy fetuses (World Health Organization fetal growth chart) versus a chart commonly used by pathologists (Archie et al.) derived from fetal autopsy-based populations in diagnosing small-for-gestational-age (SGA) birth in perinatal deaths. Study Design: We examined perinatal deaths that underwent autopsy at BC Women's Hospital, 2015-2021. Weight centiles were assigned using the ultrasound-based fetal growth chart for birthweight and autopsy-based growth chart for autopsy weight. Results: Among 352 fetuses, 30% were SGA based on the ultrasound-based fetal growth chart versus 17% using the autopsy-based growth chart (p < 0.001). Weight centiles were lower when using the ultrasound-based versus autopsy-based growth chart (median difference of 9 centiles [IQR 2, 20]). Conclusions: Autopsy-based growth charts may under-classify SGA status compared to ultrasound-based fetal growth charts. [ABSTRACT FROM AUTHOR]

AbstractWe have developed a heat transfer correlation for saturated flow boiling of water in a helically coiled tube. Initially, we collected experimental data encompassing a broad spectrum of thermal-hydraulic conditions and geometric configurations, and examined the influences of key dimensionless parameters, such as the convection number and the boiling number. The data analysis showed that the observed trend aligns with previous studies on boiling heat transfer within a straight tube. Also, we investigated the influence of centrifugal force acting on the fluid in a helically coiled tube and confirmed its significant impact on boiling heat transfer. Based on our findings, we propose a new heat transfer correlation that incorporates a dimensionless number of the centrifugal force divided by gravitational force. The basic structure of this correlation was adapted from the Kandlikar correlation for saturated flow boiling. The new correlation demonstrated enhanced accuracy compared to existing ones. Additionally, we showed its applicability to boiling heat transfer within a straight tube as well. [ABSTRACT FROM AUTHOR]

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In case of a nuclear accident, individuals with high-dose radiation exposure (>1–2 Gy) should be rapidly identified. While ferredoxin reductase (FDXR) was recently suggested as a radiation-responsive gene, the use of a single gene biomarker limits radiation dose assessment. To overcome this limitation, we sought to identify reliable radiation-responsive gene biomarkers. Peripheral blood mononuclear cells (PBMCs) were isolated from mice after total body irradiation, and gene expression was analyzed using a microarray approach to identify radiation-responsive genes. In light of the essential role of the immune response following radiation exposure, we selected several immune-related candidate genes upregulated by radiation exposure in both mouse and human PBMCs. In particular, the expression of ACOD1 and CXCL10 increased in a radiation dose-dependent manner, while remaining unchanged following lipopolysaccharide (LPS) stimulation in human PBMCs. The expression of both genes was further evaluated in the blood of cancer patients before and after radiotherapy. CXCL10 expression exhibited a distinct increase after radiotherapy and was positively correlated with FDXR expression. CXCL10 expression in irradiated PBMCs represents a potential biomarker for radiation exposure. [ABSTRACT FROM AUTHOR]

Given the importance of teaching and learning argumentation, across disciplines for participation in academic and civil discourse, this article examines how dialogic space is created and sustained in classrooms where argument is taught and learned and, when it is created, what affordances it brings to learning argumentation. Dialogic space is a shared space of mutual resonance where we see, feel, or think things from at least 2 points of view at once. While any instructional setting has the potential to create dialogic space, this potential is not always realized. Using data from previously published research on classroom discourse around argumentation in secondary English language arts classrooms, I present how dialogic space can be opened, deepened, and widened as well as how teachers can engage students in argumentation within this space. I conclude by briefly discussing the contexts and affordances of creating dialogic space in argument classrooms. [ABSTRACT FROM AUTHOR]

A cochleate formulation was developed to enhance the oral bioavailability of revaprazan (RVP). Dimyristoyl phosphatidylcholine (DMPC) liposome containing dicetyl phosphate (DCP) successfully formed a cochleate after treatment with CaCl2, whereas that containing sodium deoxycholate did not. Cochleate was optimised using a D-optimal mixture design with three independent variables—DMPC (X1, 70.58 mol%), cholesterol (X2, 22.54 mol%), and DCP (X3, 6.88 mol%)—and three response variables: encapsulation efficiency (Y1, 76.92%), released amount of free fatty acid at 2 h (Y2, 39.82%), and released amount of RVP at 6 h (Y3, 73.72%). The desirability function was 0.616, showing an excellent agreement between the predicted and experimental values. The cylindrical morphology of the optimised cochleate was visualised, and laurdan spectroscopy confirmed the dehydrated membrane interface, showing an increased generalised polarisation value (approximately 0.5) over small unilamellar vesicle of RVP (RVP-SUV; approximately 0.1). The optimised cochleate showed greater resistance to pancreatic enzyme than RVP-SUV. RVP was released in a controlled manner, achieving approximately 94% release in 12 h. Following oral administration in rats, the optimised cochleate improved the relative bioavailability of RVP by approximately 274%, 255%, and 172% compared to RVP suspension, a physical mixture of RVP and the cochleate, and RVP-SUV, respectively. Thus, the optimised cochleate formulation might be a good candidate for the practical development of RVP. [ABSTRACT FROM AUTHOR]

Cervical lymph node metastasis (CLNM) from remote primary sites is rare in head and neck cancer. The efficacy of neck dissection is still being investigated for therapeutic benefits of local management in oligometastasis from non-head and neck cancer. To evaluate the clinical efficacy of neck dissection (ND) in CLNM from distant primary cancers and identify factors contributing to improved survival. This retrospective case-control study enrolled patients who underwent ND for CLNM from distant primary cancer at Asan Medical Centre between January 2010 and December 2020. We analysed overall survival and association between clinical covariate and survival. The study included 31 (14 males, 17 females) among 114 patients. Ovarian cancer was the most common primary malignancy (32.3%). Patients with fewer than three metastatic lymph nodes, without extranodal extension and with adjuvant therapy after surgery had better survival rates. In patients with CLNM from a distant primary cancer, ND is beneficial as local treatment. And adequate selection of patients for ND is pivotal to improve prognosis. [ABSTRACT FROM AUTHOR]

This article examines the power imbalance associated with core-periphery structure in disaster response networks, drawing on resource dependence, institutional, and network theories. By employing Borgatti and Everett's (1999) algorithm and Bayesian logistic mixed-effects models to analyse data on collaborative ties among organizations that responded to the 2015 epidemic in South Korea, the authors found that a network with a small core emerged during the public health crisis. The ability for organizations to not only provide but also attract resources and the professional and governmental positions that they had held in the disaster management system were associated with the core-periphery structure. [ABSTRACT FROM AUTHOR]

Bioluminescence is a type of chemiluminescence that arises from a luciferase-catalyzed oxidation reaction of luciferin. Molecular biology and comparative genomics have recently elucidated the genes involved in fungal bioluminescence and the evolutionary history of their clusters. However, most studies on fungal bioluminescence have been limited to observing the changes in light intensity under various conditions. To understand the molecular basis of bioluminescent responses in Omphalotus guepiniiformis under different environmental conditions, we cloned and sequenced the genes of hispidin synthase, hispidin-3-hydroxylase, and luciferase enzymes, which are pivotal in the fungal bioluminescence pathway. Each gene showed high sequence similarity to that of other luminous fungal species. Furthermore, we investigated their transcriptional changes in response to abiotic stresses. Wound stress enhanced the bioluminescence intensity by increasing the expression of bioluminescence pathway genes, while temperature stress suppressed the bioluminescence intensity via the non-transcriptional pathway. Our data suggested that O. guepiniiformis regulates bioluminescence to respond differentially to specific environmental stresses. To our knowledge, this is the first study on fungal bioluminescence at the gene expression level. Further studies are required to address the biological and ecological meaning of different bioluminescence responses in changing environments, and O. quepiniiformis could be a potential model species. [ABSTRACT FROM AUTHOR]

Many of community supports and resources were shattered in the COVID-19 pandemic, leaving parents to navigate caring for their adult child with intellectual disabilities with little support. This study explored caregiving stress experienced by parents of adult children with intellectual disabilities during the COVID-19 pandemic in Korea. In-depth interviews were conducted with 19 parents of an adult child with intellectual disabilities. Thematic analysis yielded two themes: caregiving burden and deteriorating health. Parents bore the brunt of the caregiving burden, spending much of their time helping their adult child with daily activities and managing their challenging behaviors, leaving the caregivers struggling physically and mentally. The heightened caregiver burden and associated deteriorating health among these parents raise serious concerns, indicating a need for immediate support to alleviate these issues and help parents navigate caring for their adult child with intellectual disabilities during the COVID-19 pandemic. [ABSTRACT FROM AUTHOR]