1. Two new oleanane triterpenes from Maytenus hookeri.
- Author
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Yang, Quan-Yu, Yang, Song-Xue, Wei, Qiong, Ma, Yan-Zi, Li, Bo, Wu, Xue-Wen, Zhang, Rui-Han, Zhang, Xing-Jie, Li, Xiao-Li, and Xiao, Wei-Lie
- Subjects
TRITERPENES ,ANTI-inflammatory agents ,IN vitro studies ,HIGH performance liquid chromatography ,RESEARCH funding ,NUCLEAR magnetic resonance spectroscopy ,COLORIMETRY ,PLANT stems ,CELL proliferation ,PHYTOCHEMICALS ,LACTATE dehydrogenase ,ANALYTICAL biochemistry ,PLANT extracts ,CELL lines ,CELL culture ,MEDICINAL plants ,MOLECULAR structure ,SPECTRUM analysis ,COLLECTION & preservation of biological specimens ,CELL survival ,SIGNAL peptides ,SPECTROPHOTOMETRY - Abstract
Two new triterpenes mayteneri A (1), mayteneri B (2), and seven known compounds (3-9) were isolated from stems of Maytenus hookeri Loes. The chemical structures of compounds 1 and 2 were established by 1D, 2D NMR, HRESIMS analysis, and calculating electronic circular dichroism (ECD). The structures of known compounds 3-9 were determined by comparison of their spectral with those reported. Compounds 4-7 showed significant inhibitory activity for NLRP3 inflammasome, with the IC
50 values of 2.36–3.44 μM. [ABSTRACT FROM AUTHOR]- Published
- 2024
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