1. Grape seed extract prevents oestrogen deficiency-induced bone loss by modulating the gut microbiota and metabolites.
- Author
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Lu L, Li J, Liu L, Wang C, Xie Y, Yu X, and Tian L
- Subjects
- Animals, Mice, Female, Lipid Metabolism drug effects, Dysbiosis prevention & control, Mice, Inbred C57BL, Bacteria metabolism, Bacteria classification, Bacteria drug effects, Bacteria genetics, Osteoporosis prevention & control, Disease Models, Animal, Adipose Tissue metabolism, Ovariectomy, Gastrointestinal Microbiome drug effects, Grape Seed Extract pharmacology, Estrogens deficiency, Estrogens metabolism
- Abstract
Proanthocyanidin-rich grape seed extract (GSE) has been shown to have the potential to protect bones, although the underlying mechanism remains unknown. The current study aims to explore GSE's preventive and therapeutic impact on bone loss induced by oestrogen deficiency and the underlying mechanism through the gut microbiota (GM) and metabolomic responses. In oestrogen-deficient ovariectomized (OVX) mice, GSE ameliorated bone loss by inhibiting the expansion of bone marrow adipose tissue (BMAT), restoring BMAT lipolysis and promoting bone formation. GSE regulated OVX-induced GM dysbiosis by reducing the abundance of opportunistic pathogenic bacteria, such as Alistipes, Turicibacter and Romboutsia, while elevating the abundance of beneficial bacteria, such as Bifidobacterium. The modified GM primarily impacted lipid and amino acid metabolism. Furthermore, the serum metabolites of GSE exhibited a significant enrichment in lipid metabolism. In summary, GSE shows potential as a functional food for preventing oestrogen deficiency-induced bone loss by modulating GM and metabolite-mediated lipid metabolism., (© 2024 The Author(s). Microbial Biotechnology published by John Wiley & Sons Ltd.)
- Published
- 2024
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