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This article examines the role of CD147, a protein found on certain immune cells, in the development and recurrence of psoriasis. The study discovered that high levels of CD147 on CD4+ T cells were associated with the effectiveness of IL-17A inhibitor treatment and the likelihood of psoriasis returning. The researchers developed two models that accurately predicted treatment outcomes and long-term effectiveness based on CD147 levels. Additionally, the study found that a lack of CD147 on CD4+ T cells worsened psoriasis and increased the chances of it coming back. These findings provide valuable insights into the causes of psoriasis and could inform personalized treatment approaches. [Extracted from the article]

This paper presents an experimental investigation into the flexural and cracking behavior of corroded reinforced concrete continuous beams with 11‐month wet–dry cycles strengthened by anodic polarized carbon‐fabric‐reinforced cementitious matrix (C‐FRCM) plates. The failure modes and flexural bearing capacities were discussed. The influences of the layer of carbon fabric mesh and complete carbon fiber‐reinforced polymer (CFRP) wrapping as end anchorage on the strengthening effectiveness were explored. The complete crack development patterns were captured by a digital image correlation system, and the results showed that the C‐FRCM system can provide satisfactory crack width control, as proved by the reduced crack spacing and the maximum crack width. The flexural capacities of the strengthened beams were effectively enhanced and the debonding failure can be eliminated through complete CFRP wrappings. Moreover, the design recommendations were proposed based on the estimation of the crack development as per related design guidelines. [ABSTRACT FROM AUTHOR]