1. JAKi: Can it be used to treat SAPHO syndrome?
- Author
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Yue, Qingyun, Ma, Mingwei, Liu, Shengyan, Wu, Yuanhao, and Li, Chen
- Subjects
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FOOT pain , *CLAVICLE injuries , *SYNDROMES , *JOINT diseases , *LUMBAR pain - Abstract
This article explores the potential use of Janus kinase inhibitors (JAKi) in treating SAPHO syndrome, a rare autoinflammatory disease that affects the skin and skeletal system. JAKi can block the action of various cytokines involved in inflammation, making them potentially more effective than biologics that only target one cytokine. The article presents case reports of SAPHO syndrome patients who experienced symptom improvement after treatment with JAKi, specifically tofacitinib, baricitinib, and upadacitinib. However, more research is needed to validate the efficacy of JAKi in treating SAPHO syndrome, including studies on tapering or discontinuation of JAKi and potential relapses or treatment failures. [Extracted from the article]
- Published
- 2024
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