Search

Alzheimer's disease (AD) is a popular neurological disorder affecting a critical part of the world's population. Its early diagnosis is extremely imperative for enhancing the quality of patients' lives. Recently, improved technologies like image processing, artificial intelligence involving machine learning, deep learning, and transfer learning have been introduced for detecting AD. This review describes the contribution of image processing, feature extraction, optimization, and classification approach in AD recognition. It deeply investigates different methods adopted for multiclass diagnosis of AD. The paper further presents a brief comparison of existing AD studies in terms of techniques adopted, performance measures, classification accuracy, publication year, and datasets. It then summarizes the important technical barriers in reviewed works. This paper allows the readers to gain profound knowledge regarding AD diagnosis for promoting extensive research in this field. [ABSTRACT FROM AUTHOR]

The most fundamental oversight in Artificial Intelligence (AI) is probably the avoidance of conscious learning. The most widespread misconduct in AI seems to be Post-Selection. Avoiding conscious learning, we program humanoid robots that do not have the intent to learn new skills, such as standing up, walking, jumping, speaking, and thinking. Because programmed-in skills are all brittle, we must imitate natural intelligence, from insects to humans, that all learn from consciousness. Worldwide AI researchers and the public have been misled by media hypes about false AI performances, from Deep Learning to ChatGPT, rooted in Post-Selection. However, the Post-Selection protocol behind such hypes is fatally flawed by alleged misconduct — Misconduct 1, Cheating in the absence of a test; Misconduct 2, hiding bad-looking data. In other words, the reported errors are only data-fitting errors, instead of testing errors. This paper discusses how Conscious Learning is enabled by Developmental Network 3 (DN-3) to learn from its own intents without Post-Selection misconduct. Among many new concepts presented here, this paper establishes a new theorem that the expected error of the luckiest system in a future test is the same as any other less lucky system, namely, average. In contrast, DN-3 develops a sole network that is optimal in the sense of maximum likelihood (ML), better than the luckiest system on a validation set. The ML optimality transfers the performance on a validation set in the prior lifetime to a test set in the future lifetime. Many other AI techniques, e.g., symbolic, connectionist, and evolutional, also use Post-Selection which lacks such a transfer. [ABSTRACT FROM AUTHOR]

Teachability has been extensively studied under the context of making industrial robots to be programmable and reprogrammable. However, it is only recently that the artificial intelligence (AI) research community is accelerating the research works with the objective of making humanoid robots and many other robots to be teachable under the context of using natural languages. We human beings spend many years learning knowledge and skills despite our extraordinary mental capabilities of being teachable with the use of natural languages. Therefore, if we would like to develop human-like robots such as humanoid robots, it is inevitable for us to face the issue of making future humanoid robots teachable with the use of natural languages as well. In this paper, we present the key details of a top-down design for achieving a teachable mind which consists of two major processes: the first one is the process that enables humanoid robots to gain innate mental capabilities of transforming incoming signals into meaningful crisp data, and the second one is the process which enables humanoid robots to gain innate mental capabilities of undertaking incremental and deep learning with the main focus of associating conceptual labels in a natural language to meaningful crisp data. These two processes consist of the two necessary and sufficient conditions for future humanoid robots to be teachable with the use of natural languages. In addition, this paper outlines a very likely new finding underlying the human brain's neural systems as well as the obvious mathematics underlying artificial deep neural networks. These outlines provide us with a strong reason to separate the study of the mind from the study of the brain. Hopefully, the content discussed in this paper will help the AI research community to venture into the right direction which is to make future humanoid robots, non-humanoid robots, and many other systems to achieve human-like self-intelligence at the cognitive level with the use of natural languages. [ABSTRACT FROM AUTHOR]

Artificial intelligence (AI)-based approaches are crucial in computer-aided diagnosis (CAD) for various medical applications. Their ability to quickly and accurately learn from complex data is remarkable. Deep learning (DL) models have shown promising results in accurately classifying Alzheimer's disease (AD) and its related cognitive states, Early Mild Cognitive Impairment (EMCI) and Late Mild Cognitive Impairment (LMCI), along with the healthy conditions known as Cognitively Normal (CN). This offers valuable insights into disease progression and diagnosis. However, certain traditional machine learning (ML) classifiers perform equally well or even better than DL models, requiring less training data. This is particularly valuable in CAD in situations with limited labeled datasets. In this paper, we propose an ensemble classifier based on ML models for magnetic resonance imaging (MRI) data, which achieved an impressive accuracy of 96.52%. This represents a 3–5% improvement over the best individual classifier. We evaluated popular ML classifiers for AD classification under both data-scarce and data-rich conditions using the Alzheimer's Disease Neuroimaging Initiative and Open Access Series of Imaging Studies datasets. By comparing the results to state-of-the-art CNN-centric DL algorithms, we gain insights into the strengths and weaknesses of each approach. This work will help users to select the most suitable algorithm for AD classification based on data availability. [ABSTRACT FROM AUTHOR]

In recent years, machine learning algorithms have been widely adopted across many fields due to their efficiency and versatility. However, the complexity of predictive models has led to a lack of interpretability in automatic decision-making. Recent works have improved general interpretability by estimating the contributions of input features to the predictions of a pre-trained model. Drawing on these improvements, practitioners seek to gain causal insights into the underlying data-generating mechanisms. To this end, works have attempted to integrate causal knowledge into interpretability, as non-causal techniques can lead to paradoxical explanations. In this paper, we argue that each question about a causal effect requires its own reasoning and that relying on an initial predictive model trained on an arbitrary set of variables may result in quantification problems when estimating all possible effects. As an alternative, we advocate for a query-driven methodology that addresses each causal question separately. Assuming that the causal structure relating the variables is known, we propose to employ the tools of causal inference to quantify a particular effect as a formula involving observable probabilities. We then derive conditions on the selection of variables to train a predictive model that is tailored for the causal question of interest. Finally, we identify suitable eXplainable AI (XAI) techniques to estimate causal effects from the model predictions. Furthermore, we introduce a novel method for estimating direct effects through intervention on causal mechanisms. [ABSTRACT FROM AUTHOR]