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For over two decades, France's Muslim population has faced a series of legal measures and hostile public narratives aimed at problematizing their faith. Notable examples include the 2004 national ban on "ostentatious religious symbols" in state schools, which prohibits obligatory religious dress in various settings. These individual instances are compounded by more recent broader policies, decisions, laws, and executive statements that negatively impact Muslim life. This paper examines France's trajectory from a new perspective: A Muslim legal viewpoint. It argues that the French approach constitutes a two-step process of institutionalized Islamophobia, understood here as hostility towards Islam as a faith. First, the state redefines mainstream Islamic orthopraxy as "extreme", pitting ordinary religious practices against averred Republican values. Second, it seeks to promote an alternative concept of a "French Islam"—one that aligns with France's secular principles and is stripped of its religious essence—positioning it as the only acceptable framework for Muslims to practice their faith in France. We argue that this process is not about upholding laïcité or state neutrality; rather, invoking the latter serves as a smokescreen for the state's Islamophobia. [ABSTRACT FROM AUTHOR]

Introduction: Haematology is a speciality frequently confronted with end-of-life situations, and teams will be concerned by the question of medical assistance in dying. The Ethics Commission of the French Society of Haematology has conducted a survey on the knowledge and perceptions of healthcare professionals regarding complex end-of-life situations. Methods: A cross-sectionalonline survey of hematology professionals in France. The comprehensive online questionnaire addressed respondents' experience of complex end-of-life situations in hematology, based on 7 clinical vignettes. The survey contained 55 questions, 6 of which were open-ended. They were asked to give their opinion on whether it should be legalized. Justifications were then requested and analyzed by theme. Results: The survey was distributed to associations of hematology healthcare professionals (approximately 1,300 members). Overall, 182 healthcare professionals replied, including a third nurses and a third physicians. The average score for identifying complex situations was 7.1 out of 10 (IQR 5.7,8.6), with lesser knowledge of situations involving double effect, euthanasia and sedation for distress than of situations involving limiting or stopping treatment. Training in palliative care was the main driver of knowledge (p = 0.004), as well as being a physician (p < 0.001). We found that the opinions of healthcare professionals regarding the legalization of medical assistance in dying in France were diverse and well-founded. Conclusion: Hematology healthcare professionals had lesser knowledge of situations involving double effect, euthanasia and sedation for distress. Knowledge of specific situations impacts professionals' opinion on legalization of medical assistance in dying. [ABSTRACT FROM AUTHOR]

Migration studies have highlighted the crucial role of civil society organisations (CSOs) in the local politics of migration. Less explored is the impact of the material conditions under which CSOs operate. And yet CSOs delivering public services to migrant and racialised populations often rely on public funding which has been significantly restructured since neoliberal welfare reforms in many Western countries in the 1990s. This article examines how funding contexts shape the opportunities of CSOs to influence local policymaking on migration and migration-related change from a cross-country and cross-city comparative perspective. Based on the empirical analysis of four cities in France and Germany and a comprehensive dataset comprising interviews, observations and documents, we argue that funding contexts significantly impact on CSOs' potential to shape local policymaking. They do so by enhancing and restricting (1) CSOs' access to spaces of policymaking as well as (2) CSOs' capacities for political engagement. We demonstrate the mediating importance of specific funding structures and politics at both national and local scales as well as the role of state-CSO relations in manifesting and reproducing these funding contexts. [ABSTRACT FROM AUTHOR]

Parental reactions to children's negative emotions (PRCNEs), a type of emotion socialization, has been theorized to shape children's socioemotional development. Few studies have examined cultural variations in PRCNE among Western/Minority World cultures. The present study used a cross-cultural, preschool-based sample of 101 parent–child dyads (child age = 36–79 months, 42% females; parent age = 19–58 years, 89% mothers) from two countries: U.S. (n = 33, 58% White/European American, 87% with college or above education) and France (n = 68, 61% French or other European origin, 40% with college or above education). Parents self-reported PRCNEs across 12 hypothetical scenarios. Children's behavioral problems and prosocial behaviors were rated by parents and preschool teachers. Children's emotion knowledge was measured by a behavioral task. We examined (1) cultural group variations in PRCNEs, and (2) the relations between PRCNE and children's socioemotional outcomes. Controlling for demographics, French parents endorsed more non-supportive PRCNE than U.S. parents. Across both cultures, parents' higher use of distress and punitive reactions were linked to lower parent-rated child prosocial behaviors. These findings revealed differences and similarities in PRCNEs between French and U.S. families and have implications for early childhood education practices promoting socioemotional competence. [ABSTRACT FROM AUTHOR]

Background: Interprofessional relationships between general practitioners (GPs) and dental surgeons with a doctorate in dental surgery are essential for the optimal management of the oral health of patients. The objectives of this study were to describe the factors associated with the referral of patients from GPs to dental surgeons in France, and to improve referral practices by establishing a standardized set of items to be included in a referral letter., Methods: A nationwide, observational, survey-based, cross-sectional study was conducted from 9 February 2023 to 6 April 2023. Two 13-item questionnaires were sent to GPs and dental surgeons. Data on practitioner characteristics, frequency, and perceived usefulness of medical correspondence between the two healthcare professionals were collected. Candidate items selected by expert medical opinion for a standardized referral letter template were appraised by the responding oral surgeons., Results: A group of 245 dental surgeons (mean age: 38.2 ± 11.1 years, 64.5% female) and 235 GPs (mean age: 36.8 ± 9.8 years, 71.9% female) participated in this study. Medical correspondence between GPs and dental surgeons was reported to be insufficient by most dental surgeons (91.4%). Dental surgeons agreed that GP correspondence could decrease the occurrence of adverse events linked with dental care (mean score: 7.36 ± 2.4, for a maximum of 10). Only 20% of GPs indicated that they had regular communication with dental surgeons. The physician characteristics under study were not statistically associated with initiating referrals. The items most frequently selected by dental surgeons for inclusion in a template referral letter were the presence of diabetes (99.6%), of immunosuppression (98.8%), and medication by anticoagulant or antiplatelet agents (98.3%)., Conclusions: Despite known links between oral and general health, most healthcare professionals did not engage in correspondence or referrals with the other specialty. Standardized referral letters could include the list of items for which interest was confirmed by dental surgeons (including presence of diabetes, immunosuppressants and anticoagulants or antiplatelet agents)., Competing Interests: Declarations. Ethics approval and consent to participate: In accordance with the French legislations No. 2021 − 300 (March 5, 2012), this observational study did not require approval by an ethics committee. This study was also not subject to Jardé law since it did not fall within the scope of Article R.1121-1 of the French Public Health Code. Informed consent was obtained from all physicians to participate in the study. Competing interests: The authors declare no competing interests., (© 2025. The Author(s).)

Background: Numerous agents in the workplace are suspected of impairing fetal growth. To date, no epidemiological studies have specifically described the occupational exposome during pregnancy., Objective: The objectives were to determine maternal occupational exposome profiles and study their associations with intrauterine growth characteristics measured by small for gestational age (SGA), birthweight (BW), and head circumference (HC)., Methods: We used data from the French national ELFE cohort. Occupational exposures to 47 agents (chemical, physical, biological, biomechanical, organizational and psychosocial), were identified using job exposure matrices. Mothers were classified as occupationally not exposed, uncertainly exposed, or exposed depending on their probability of exposure. Outcomes of interest were BW, SGA and HC. Maternal profiles of the occupational exposome were determined using hierarchical clustering of principal components. Associations between profiles and intrauterine growth outcomes were studied using linear or logistic regression models adjusted for potential confounders. Analyses were carried out depending on whether mothers stopped working during pregnancy., Results: The 12,851 included women were exposed to a median of 6 factors. Four occupational exposome profiles were identified, characterized by "low exposure, stress at work"; "strenuous, high organization, low decision"; "postural constraints, psychosocial factors", "postural and strength constraints, chemical and biological factors". In multivariate analyses, and among women who stopped working during the third trimester of pregnancy, analyses found associations between the profile "postural constraints, psychosocial factor" and SGA, and HC. None of the other exposure profiles were statistically significantly associated with foetal growth outcomes., Conclusion: The results show that the specific profile "postural constraints, psychosocial factors" may increase the risk of foetal growth retardation. Although these results need to be replicated, this study provides a first better understanding of the exposome of pregnant women at the workplace which may help to better adapt prevention strategies., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)

Background: Despite vaccination, patients receiving anti-CD20 monoclonal antibodies (mAbs) for multiple sclerosis (MS) or neuromyelitis optica spectrum disorders (NMOSD) have an increased risk of developing severe or protracted COVID-19. The aim of this study was to describe the effect of COVID-19 convalescent plasma (CCP) in patients with MS or NMOSD exposed to anti-CD20 and infected by SARS-CoV-2., Methods: This French national, retrospective cohort study was conducted between November 2020 and June 2023. Patients with MS or NMOSD, under anti-CD20 mAbs, with symptomatic COVID-19 and treated by CCP were screened. Protracted COVID-19 was defined by a duration of symptoms >21 days. The primary endpoint was the overall survival 30 days after CCP administration., Results: Ninety-two patients from 34 hospitals were included, 84 (91%) with MS and 8 (9%) with NMOSD. Overall, 30-day survival was 97% (IC95%: 91-99). SARS-CoV-2 viremia was positive in 47/75 (61%) patients before CCP versus 9/59 (15%) seven days post-CCP. In the 52 patients (57%) with protracted COVID-19, the duration of symptoms before CCP was 51 [28-69] days, including fever in 75% of cases, which disappeared in 100% of patients 7 days post-CCP., Conclusions: CCP could be a therapeutic option in patients exposed to anti-CD20 mAbs for inflammatory demyelinating disease, particularly in those with protracted COVID-19., Competing Interests: Declarations of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: KL has received funds from Gilead, MSD, Janssen, ViiV Healthcare and Abbvie for expert boards and travel grants. None of those funds target COVID-19. CL has received compensation for travel fees, consulting services or speaker honoraria from Biogen, Merck Serono, Novartis, Sanofi and Roche and IIT Research grant from Biogen. AF reports honorariat by Fisher & Paykel for a lecture during SFMU Congress 2022, outside the submitted work. AM is president of an association that has received funding from GSK and Blueprint, hospitality from GSK, Novartis, Sanofi, Janssen, Teva, Shire, Ipsen, training funding from Novartis, LFB, Leo Pharma, and has a contract to speak at scientific events from Leo Pharma. The other authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.)

Aim: The aim of this study was to describe the epidemiology and bacteriological trends of carbapenemase-producing Enterobacteriaceae (CPE) at Nantes University Hospital from 2013 to 2023., Methods: Potential CPE carriers were prospectively detected, and their contacts were systematically screened for CPE digestive colonization. A retrospective study was conducted from 2013 to 2023 (on patient characteristics) and from 2016 to 2023 (on CPE characteristics). An outbreak was defined as at least one secondary case occurring among contact patients during the same hospitalization, in the same unit, and with the same staff., Results: All in all, 553 CPE-positive carriers were identified during the study period. Among them, 178 (32 %) were sporadic cases and 100 (18 %) were incidentally detected. Fifty-seven outbreaks were investigated comprising 305 (55 %) secondary cases. The most commonly identified CPE species in outbreaks were Klebsiella pneumonia OXA-48., Conclusion: CPE detection in the hospital was associated mainly with epidemic spread involving a variable number of secondary cases. CPE patients detected incidentally (without specific infection control measures) several days after hospital admission, repatriates and patients with a history of hospitalization abroad are at high risk of in-hospital CPE spread. The number of outbreaks did not decrease during the study period, and more generally, the number of secondary cases tends in some uncontrolled situations to increase, particular when CPE- positive patients are transferred or rehospitalized., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2025 Elsevier Masson SAS. All rights reserved.)

Introduction: General Practitioners (GPs) play a key role of gatekeeper, as they coordinate patients' care. However, most of them reported having difficulty to refer patients to hospital, especially in semi-urgent context. To facilitate the referral of semi-urgent patients, we implemented an e-referral platform, named SIPILINK, within 4 wards from a large public French hospital (internal medicine, diabetology, gynaecological surgery and oncology wards). Here, we aimed to evaluate the SIPILINK e-referral platform after 2 years of implementation., Methods: The evaluation included a multidimensional assessment based on the RE-AIM framework with the analysis of implementation, requests, health professionals' satisfaction, and estimated hospital payment., Results: Over 2 years of implementation, GPs sent 113 requests to hospital. Hospital respected the time of response requested by GPs in 93 % of cases and proposed a consultation or hospitalization in respectively 40.7 % and 10.6 % of cases. 100 % of GPs and 78 % of Hospital Practitioners (HPs) were satisfied with the quality of exchanges. 77 % of HPs and 100 % of Care Pathway Managers (CPMs) found that patient care pathways were improved. Nearly all practitioners would recommend this platform for patient referrals., Discussion: SIPILINK shows promise in streamlining the referral process, enhancing communication, and improving patient care pathways. Further studies including the impact on the quality of care, are needed to assess its effectiveness and sustainability in healthcare settings., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.)

Exposure to environmental chemicals has been associated with higher risk of childhood allergies. This study aimed to examine the association between infant's dietary exposure to mixtures of chemicals and allergic and respiratory multimorbidity in childhood. Dietary exposures were assessed at 8 and 12 months in 724 and 745 children of the EDEN cohort. Allergic and respiratory multimorbidity clusters were identified using latent class analyses. Associations between dietary exposure to mixtures of chemicals and allergic clusters were assessed by adjusted multinomial logistic regressions. At 8 months, higher exposure to a mixture of furans, trace elements, dioxins and PAHs was positively associated with the "asthma only" cluster, while moderate exposure to a mixture of PAHs, pesticides, PCBs and acrylamide was negatively associated with this cluster. A mixture of PCBs and BFRs was positively associated with the "multi-morbidity" cluster. Exposure to a mixture of pesticides and trace elements was positively associated with the "allergy without asthma" cluster. At 12-months, higher exposure to a mixture of trace elements and pesticides was positively associated with "multi-morbidity" cluster. The differences in findings between the two ages suggest the need for further studies to explore this critical window of chemical exposure and its impact on children's health., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)

Introduction: While a number of studies have examined the effects of prenatal exposure to per- and polyfluoroalkyl substances (PFAS) on childhood obesity, the results reported have been inconsistent and few studies have integrated biological markers. The aim of this study was to investigate the associations between prenatal exposure to PFAS and cardiometabolic health parameters at age 12, taking pubertal stage into consideration., Method: This study included 394 mother-child pairs enrolled in the PELAGIE mother-child cohort (France). Nine PFAS were measured in umbilical cord blood, and the children attended a clinical examination at age 12. Anthropometry, blood metabolic markers, and blood pressure were measured and used to build an internal cardiometabolic score. Linear regression and Quantile G-computation models were used to evaluate individual and mixture PFAS effects, adjusting for confounders and stratifying by sex and pubertal stage., Results: No statistically significant association was observed between prenatal exposure to PFAS and cardiometabolic score at age 12. In post-menarche girls, perfluorohexane sulfonate (PFHxS) and perfluorodecanoic acid (PFDA) were statistically significantly associated with a decrease in a number of adiposity parameters (e.g., Body mass index z-score: beta [95%CI] = -0.37 [-0.67; -0.07]), as well as a decrease in low-density lipoproteins (LDL) and leptin levels. Similar results were observed with PFAS mixture, with statistically significantly decreased tricipital skinfolds (beta [95%CI] = -1.30 [(-2.54;-0.06)]). Isolated associations, including higher systolic blood pressure, changes in cholesterol levels, and lower adiponectin levels were observed in specific subgroups., Conclusion: There is no clear evidence of an association between prenatal exposure to PFAS and the cardiometabolic health at earlier stage of pubertal development. However, inverse associations between PFAS and anthropometric measures have been observed in post-menarche girls. While the literature on this topic is scarce in pre-adolescents, these results suggest the importance of considering sex and pubertal stage in these associations., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)

The adoption of residential renewable energy is pivotal for achieving the 'Net Zero' goal, yet financial assessments of household investments in this area remain complex due to dynamic market conditions. This study introduces a novel closed-form financial valuation framework for residential solar photovoltaic (PV) systems, explicitly addressing the uncertainties of electricity market price fluctuations (market risk) and energy policy changes (policy risk) using Geometric Brownian Motion (GBM). A case study in France demonstrates the framework's application, revealing that the discount rate is the most influential factor in solar PV valuation, followed by system lifespan and policy-driven Feed-in Tariff (FiT) rates. Sensitivity analyses further highlight how these variables interact to influence investment outcomes under various market scenarios. Key findings include (1) the identification of critical thresholds for solar PV investments, ensuring financial viability even under fluctuating conditions; (2) the validation of GBM as an effective tool for capturing long-term market and policy dynamics; and (3) actionable policy recommendations emphasizing market efficiency, policy stability, and end-of-life management. These insights contribute to advancing both household investment decision-making and policy design, addressing a significant gap in understanding the economic dynamics of residential renewable energy adoption. By bridging theoretical valuation models with empirical evidence, this research provides practical guidance for promoting decentralized renewable energy systems globally., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2025 The Authors. Published by Elsevier Ltd.. All rights reserved.)

Objectives: To describe the presentation and therapeutic management of severe cholera in Mayotte (France)., Patients and Methods: We carried out retrospective data collection. All patients treated in the intensive care unit (ICU) with a confirmed diagnosis of cholera by PCR were studied. Only patients treated for hypovolemia were included., Results: Out of the 215 confirmed cases of cholera in Mayotte on July 12, 2024, 25 required treatment in the ICU (11.6 %). Among these cases, 16 were treated for hypovolemia (7.4 %), while five patients died of cholera before they could be admitted to hospital (lethality rate 2.3 %). No patient died in hospital. Median patient age was 17 years (4-30) with a sex ratio of 1. Severe diarrhea was the rule with a median of one diarrheal stool every two hours. Clinical severity was characterized by sunken eyes and Glasgow Coma Scale (GCS) < 14 (n = 16/16,100 %). Biological severity was determined by profound metabolic acidosis with venous pH < 7.20 (n = 16/16, 100 %). Intravenous fluid therapy was aggressive with a median of 280 mL/kg (230-300) Ringer's lactate solution during the first 48 h., Conclusions: Cholera can be a life-threatening infection, with deaths occurring due to severe diarrhea and hypovolemia. From the onset of symptoms, which are sometimes fulminant, patients must be admitted to a care center as soon as possible. We will continue to collect data to create scores that will enable us to better recognize the most severe forms of the disease., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Author(s). Published by Elsevier Masson SAS.. All rights reserved.)

Background/Objectives: The global population is undergoing a significant demographic shift characterised by an increasing proportion of older individuals. Healthy aging has become a priority for personal well-being and sustainable healthcare systems, with nutrition playing a pivotal role. However, the rise in non-communicable diseases (NCDs), malnutrition, and a shift in eating behaviour underscore the need for tailored, effective nutrition communication strategies. This research is intended to provide the basic data needed to support the development of tailored nutritional communication strategies and practices. Methods: To investigate these aspects, a cross-national survey about nutrition and nutrition communication was conducted within the framework of the Innovative Training Network SmartAge, focusing on older adults aged 60 years and above in Germany, Switzerland, Spain, and France (each 25%; N = 1000 persons). This paper specifically focuses on the development, methodology, and discussion of the survey and aims to investigate the characteristics of the sample in relation to their dietary patterns and food choices within the European context. Results: The analysis identified significant associations between various plant- and animal-based food items and the variables gender, age group, and country. Spanish participants showed a dietary pattern towards the Mediterranean Diet, while German participants showed tendencies towards the Western Diet. Furthermore, the findings revealed that protein-rich foods such as meat, fish, nuts and seeds, legumes, and (whole) grains were infrequently consumed, particularly among German and Swiss participants. Conclusions: This study highlights the need to promote adequate protein intake among older adults, emphasising diverse sources like legumes, nuts and seeds, (whole) grains, and lean meats to support healthy aging. For the development of future nutrition communication strategies, the influence of the specific social, cultural, and traditional factors needs to be considered.

Objective: A major concern for cancer survivors after treatment is the Fear of Cancer Recurrence (FCR), which is the fear that cancer will reappear or progress. This fear can be exacerbated by medical uncertainty about the future, leading to harmful obsession and having a negative impact on quality of life. This study aims to develop a predictive Machine Learning (ML) model using healthcare reimbursement data to better predict FCR and understand the factors influencing FCR in women with breast cancer five years after their diagnosis., Materials and Methods: We used data from the VICAN (VIe après le CANcer) survey to propose an interpretable model to identify patients at risk of developing clinical FCR. The reimbursement data for each patient were analyzed beyond the first two years of treatment, excluding the initial phase influenced by the cancer curative therapeutic process. Data experiments were conducted, including the use of algorithms such as Random Forest, Support Vector Machines, Gradient Boosting, eXtreme Gradient Boosting, and Multilayer Perceptron. The AUC was used to choose the optimal model., Results: The dataset is composed of 918 patients classified regarding FCR. The experimental design incorporated classification levels of medications, biological and medical procedures. Subsequently, data was generated for two experiments, facilitating examination at the ultimate healthcare classification level in Experiment 1, while Experiment 2 targeted the penultimate classification level. Overall, the best-performing model achieved an AUC of 66%. This demonstrates some effectiveness of the algorithms in detecting patients at risk of developing clinical FCR and encourages further investigations to enhance the model's performance and assess its generalizability., Conclusion: ML applied to reimbursement data has shown promise in predicting FCR, aiding in the identification of patients at risk of developing it. The results pave the way for personalized prevention and intervention strategies, representing a significant advancement in postcancer care focusing on the needs of survivors., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.)

Chlorine is a mineral nutrient which, in a certain amount in the form of chloride, is essential for plant development. However, the atmosphere-plant transfer of its radioactive isotope, chlorine-36, is still poorly understood. In this study, dry deposition of 36 Cl on lettuce and maize was determined experimentally. These two cultures were carried out downwind of Orano La Hague plant (West of France), which chronically emits small quantities of 36 Cl. The dry deposition velocities were similar on these two canopies with mean values of and 1.4 × 10 -2  m s -1 on lettuce and 1.6 × 10 -2  m s -1 on maize crops. The measured deposition fluxes reflect the importance of the dry deposition mechanism on plants, particularly in situations of anthropogenic discharge. All these results will contribute to improving the knowledge on the fate of 36 Cl in environment, and particularly in agrosystems., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

Microplastics (MPs) and rising marine seawater temperatures are one of the major environmental problems threatening the survival of marine organisms and biodiversity. However, interactions between such multiple stressors are virtually unexplored. This study aimed to assess the combined effect of two temperatures and polyethylene MPs on the Pacific oyster Crassostrea gigas, one of the most globalized mollusc species for aquaculture. Our work highlights the potential ecological risk posed by these two factors on marine bivalve molluscs. The experimental design was carried out following a 14-day exposure of oysters to environmental concentrations of polyethylene MPs (0.01 mg.L -1 ), and to two temperatures (15 °C and 22 °C). Sampling was performed on days 0, 7, and 14. The μ-FTIR analysis was applied to quantify MPs of interest and to check a potential environmental contamination. Tissue samples of digestive glands were collected from the oysters to evaluate the activity of biomarkers including superoxide dismutase, glutathione-s-transferase, malondialdehyde and laccase through protein levels. We note that the combination of MPs and high water temperature (HWT, 22 °C) had a significant impact both on the survival of animals and on stress markers, by modifying lipid peroxidation and immune responses. This original study gave the first innovative results on this topic and provides us with knowledge of the combined effects of MPs pollution and HWT (simulating marine heatwaves situation) on C. gigas. There remains a lack of information on the toxicity and the potential environmental hazard of plastics in the marine environment., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)

The application of nature-based solutions to agriculture is promising because it allows the sustainable management of ecosystems and the reconciling of human well-being with the benefits of biodiversity. However, scientists lack robust economic arguments and concepts in the area of nature-based solutions that are well aligned with the expectations of the agricultural sector. This study addresses this gap by developing an interdisciplinary economic framework that integrates nature-based solutions and allows for an assessment of their efficient use. The conceptual framework is derived from a standard agricultural production model, making it possible to determine optimal levels of use and value. The framework is then applied to the establishment of semi-natural habitats, using econometric calibration and simulations based on agronomic, economic, psychological, and ecological data from a single case study in western France. The estimations show that the optimal semi-natural habitat coverage rate was 17.5% which was half the observed level, suggesting an underuse according to this framework. The present framework, which builds on standard economic efficiency models, demonstrates that ecosystems contribute to production similarly to conventional agricultural inputs, providing a productivity-based justification for their conservation., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

The metal Gadolinium (Gd) is a member of the lanthanide (Ln) group and is recognized as an emerging pollutant due to its widespread application in modern technology. Its acute toxicity depends on its free ion concentrations (Gd 3 + ), which is directly related to chemical speciation. The Biotic Ligand Model (BLM) is a valuable tool for risk assessment which predicts the metal bioavailability and toxicity to specific organisms. However, studies developing BLM for any Ln species are rare. Consequently, this study aimed to develop a kinetic BLM to predict the acute toxicity of Gd to the freshwater crustacean Daphnia magna. A series of 48-hour toxicity tests were conducted using different major cation concentrations, in order to estimate their affinity constants for the biotic ligand (BL). The model was then validated, first in the presence of dissolved organic matter (DOM), and then with water samples collected from lakes, rivers, and estuaries in France and Germany. The outcome revealed that three major cations (potassium, magnesium, and calcium) act as strong competitors. The model was successfully validated in the presence of organic matter and in the majority of surface freshwater samples (9 out of 13 samples). In this case, the predicted survival had a strong fit with the observed data. However, this was reduced when applying the model to samples of elevated electroconductivity and a pH below 6.8, when survival was consistently overestimated, potentially a multistressor effect. The kinetic BLM predicted 48 h measured EC 50 ranging from 4 to 30 mg L -1 which agreed with the data from the literature. The model could also predict chronic effect of Gd by estimating the no-effect concentration (NEC) under prolonged exposure time ranging from 0.1 to 1 mg L -1 ., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper, (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)

Objective: This paper describes Victoria, an empirically built data pipeline for SNDS to: - Build an automated, scalable pipeline supporting changes to the data model inherent to the use of large databases, - Deliver a documented pipeline with clear processes, enabling scientific, epidemiological researches, - Ease access to SNDS data in compliance with regulatory requirements. Methods: This paper describes the 2-steps process of the Victoria pipeline and its final output. The initial cleaning step consists in formatting, deleting empty, error or duplicate records and renaming variables without changing their values, accordingly with the official SNDS documentation. The second step consists in creating 2 linearised data models: every line of each table is an event, and each table is indexed with a unique patient identifier, without the need for a central patient or identifier table. These 2 models are: - the epidemiological model, used for answering most of the research questions requiring population phenotyping (demography, diagnosis, procedures characteristics). - the medico-economic model is used for costs and healthcare consumption analyses. It contains more complex information about reimbursements rates and the data quality assessment is focused on costs rather than medico-administrative information. Results: The pipeline was executed on 2 different datasets representing ∼85 000 and ∼870 000 beneficiaries with the following configuration: one master with 4 cores and 16Go of RAM and respectively 4 and 6 workers. The total execution time for the smaller dataset was 25 h and 96 h for the larger one. The longest part of those times is represented by the format conversion to parquet. The cleaning step took only 4 h in both cases. The epidemiological model took 344 min for the smaller dataset and 1934 min for the larger one. The medico-economic model took the longest time with 704 min and 2145 min, respectively. Conclusion: Victoria pipeline is a successfully implemented SNDS pipeline. Compared to previous pipelines, reviewability is part of its design as unit tests and quality assessments can natively be developed to ensure data and analysis quality. The pipeline has been used for 2 published studies. The recent work toward OMOP conversion will be integrated in upcoming versions and, as Victoria is set to run on a CD platform, the potential evolution if SNDS format can be considered., Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.