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Your search keyword '"Eriksson, Olof"' showing total 6 results
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6 results on '"Eriksson, Olof"'

1. Fundamental Trade-Offs in Monostatic ISAC: A Holistic Investigation Towards 6G

Author

Keskin, Musa Furkan, Mojahedian, Mohammad Mahdi, Marcus, Carina, Eriksson, Olof, Giorgetti, Andrea, Widmer, Joerg, and Wymeersch, Henk

Subjects
Electrical Engineering and Systems Science - Signal Processing
Abstract

Integrated sensing and communication (ISAC) emerges as a cornerstone technology for the upcoming 6G era, seamlessly incorporating sensing functionality into wireless networks as an inherent capability. This paper undertakes a holistic investigation of two fundamental trade-offs in monostatic OFDM ISAC systems-namely, the time-frequency domain trade-off and the spatial domain trade-off. To ensure robust sensing across diverse modulation orders in the time-frequency domain, including high-order QAM, we design a linear minimum mean-squared-error (LMMSE) estimator tailored for sensing with known, randomly generated signals of varying amplitude. Moreover, we explore spatial domain trade-offs through two ISAC transmission strategies: concurrent, employing joint beams, and time-sharing, using separate, time-non-overlapping beams for sensing and communications. Simulations demonstrate superior performance of the LMMSE estimator in detecting weak targets in the presence of strong ones under high-order QAM, consistently yielding more favorable ISAC trade-offs than existing baselines. Key insights into these trade-offs under various modulation schemes, SNR conditions, target radar cross section (RCS) levels and transmission strategies highlight the merits of the proposed LMMSE approach.

Published
2024

5. An Automotive Polarimetric Radar Sensor With Circular Polarization Based on Gapwaveguide Technology

Author

Ren, Qiannan, Eriksson, Olof, Thalya, Prateek, Elezovic, Rustem, Bencivenni, Carlo, Hasselblad, Marcus, Yang, Jian, Zang, Zhaorui, and Zaman, Ashraf Uz

Abstract

This article presents a novel design of an automotive polarimetric radar sensor with circular polarization (CP) at 77 GHz band based on gap waveguide technology. The proposed design employs a multiple-input multiple-output (MIMO) configuration with single-CP TX antennas and dual-CP RX antennas, enabling the acquisition of sufficient polarimetric information while reducing the number of transmitters (TXs) by half. Gapwaveguide technology is utilized for the implementation of the multilayer waveguide front-end. Series-fed septum polarizers are employed for the antenna design with low-profile characteristics. Measurement results indicate that the antenna elements enable a high level of cross-polarization across the field of view (FoV). Integration of the waveguide front-end with RF boards is achieved using gap waveguide packaging techniques. Static measurements were conducted on common scattering objects to evaluate the sensor’s performance. Polarimetric rotation signatures of the objects were acquired from the measurements, demonstrating the sensor’s potential for use in object identification tasks. Dynamic measurements were performed to evaluate the sensor’s Doppler response. The assessments indicate a high level of accuracy, confirming the effectiveness of the proposed sensor in analyzing dynamic movements. Overall, the proposed polarimetric radar sensor provides persuasive evidence that gap waveguide technology is a highly promising candidate for the realization of advanced automotive radar front-ends.

Published
2024
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6. Noninvasive PET Detection of CD69-Positive Immune Cells Before Signs of Clinical Disease in Inflammatory Arthritis.

Author

Puuvuori E, Shen Y, Hulsart-Billström G, Mitran B, Zhang B, Cheung P, Wegrzyniak O, Ingvast S, Persson J, Ståhl S, Korsgren O, Löfblom J, Wermeling F, and Eriksson O

Subjects
Humans, Mice, Animals, Gallium Radioisotopes, Positron-Emission Tomography, Mice, Transgenic, Disease Progression, Positron Emission Tomography Computed Tomography methods, Arthritis, Rheumatoid metabolism
Abstract

Rheumatoid arthritis (RA) is the most common inflammatory joint disease, and early diagnosis is key for effective disease management. CD69 is one of the earliest cell surface markers seen at the surface of activated immune cells, and CD69 is upregulated in synovial tissue in patients with active RA. In this study, we evaluated the performance of a CD69-targeting PET agent, [ 68 Ga]Ga-DOTA-Z CAM241 , for early disease detection in a model of inflammatory arthritis. Methods: A model of inflammatory arthritis was induced by transferring splenocytes from KRN T-cell receptor transgenic B6 mice into T-cell-deficient I-A g7 major histocompatibility complex class II-expressing recipient mice. The mice were examined longitudinally by [ 68 Ga]Ga-DOTA-Z CAM241 PET/CT before and 3, 7, and 12 d after induction of arthritis. Disease progression was monitored by clinical parameters, including measuring body weight and scoring the swelling of the paws. The uptake of [ 68 Ga]Ga-DOTA-Z CAM241 in the paws was analyzed and expressed as SUV mean Tissue biopsy samples were analyzed for CD69 expression by flow cytometry or immunostaining for a histologic correlate. A second group of mice was examined by a nonbinding, size-matched Affibody molecule as the control. Results: Clinical symptoms appeared 5-7 d after induction of arthritis. The uptake of [ 68 Ga]Ga-DOTA-Z CAM241 in the joints was negligible at baseline but increased gradually after disease induction. An elevated PET signal was found on day 3, before the appearance of clinical symptoms. The uptake of [ 68 Ga]Ga-DOTA-Z CAM241 correlated with the clinical score and disease severity. The presence of CD69-positive cells in the joints and lymph nodes was confirmed by flow cytometry and immunostaining. The uptake of the nonbinding tracer that was the negative control also increased gradually with disease progression, although to a lesser extent than with [ 68 Ga]Ga-DOTA-Z CAM241 Conclusion: The uptake of [ 68 Ga]Ga-DOTA-Z CAM241 in the inflamed joints preceded the clinical symptoms in the KRN T-cell transfer model of inflammatory arthritis, in accordance with immunostaining for CD69. [ 68 Ga]Ga-DOTA-Z CAM241 is thus a promising PET imaging marker of activated immune cells in tissue during RA onset., (© 2024 by the Society of Nuclear Medicine and Molecular Imaging.)

Published
2024
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