1. A Combination of Enteral Nutritional Support and Induction Therapy Elevates Blood Lipids, Improves Nutritional Status, and Increases Longer Overall Survival in Acute Myeloid Leukemia.
- Author
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Ouxiang Chen, Qian Sun, Wenjie Liu, Ming Hong, and Sixuan Qian
- Subjects
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TRIGLYCERIDES , *HDL cholesterol , *RETROSPECTIVE studies , *GENETIC disorders , *LDL cholesterol , *DIET therapy , *TREATMENT effectiveness , *HYPERLIPIDEMIA , *RESEARCH funding , *ENTERAL feeding , *COMBINED modality therapy , *LIPID metabolism disorders , *INDUCTION chemotherapy , *LIPIDS , *NUTRITIONAL status , *OVERALL survival - Abstract
This study aimed to explore the changes in blood lipids and nutritional indexes in acute myeloid leukemia patients before and after enteral nutritional support combined with induction therapy and assess the influences of blood lipids on prognosis. The clinical data from 210 patients with initial treatment results were retrospectively analyzed. Total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol are lower in acute myeloid leukemia patients compared to normal controls, while triglyceride levels are higher. Total cholesterol and low-density lipoprotein cholesterol levels in M2 were elevated compared to M4 and M5, and the triglyceride level in M1 was higher than M2 and M4 before therapy. High-density lipoprotein cholesterol in M2 was higher than in M1 and M5, and low-density lipoprotein cholesterol in M1 was higher than in M5. After enteral nutritional support combined with induction therapy, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and nutritional status were increased. Patients with total cholesterol ≥4.8 mmol/L after therapy had a longer overall survival. The dyslipidemia and nutritional status in newly diagnosed acute myeloid leukemia patients can be partially reversed after enteral nutritional support combined with the first induction therapy, and the rebound in total cholesterol level may reflect the longer overall survival in acute myeloid leukemia patients. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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