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The authors explore the trends in the human health risks caused by air pollution and changing levels of weather and climate comfort on the territory of Russia in 2020–2050 under two climate change scenarios. Generally, the dynamics of risks is expected to be moderate. It will presumably be characterized by inter-scenario variability and dispersion by the country's climate zones. In certain areas, primarily in Siberia, very noticeable trends have been revealed. The paper shows a need for additional attention when planning the measures of adaptation to climate change in southern and central regions of European Russia, most of Western Siberia, the Magadan oblast and Kamchatka. [ABSTRACT FROM AUTHOR]