1. Comparative analysis of a rapid diagnostic test and scoring tools for ESBL detection in Enterobacterales bloodstream infections for optimizing antimicrobial therapy.
- Author
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Andrews SR, Timbrook TT, Fisher MA, and Tritle BJ
- Subjects
- Humans, Rapid Diagnostic Tests, Ceftriaxone therapeutic use, Anti-Bacterial Agents pharmacology, Anti-Bacterial Agents therapeutic use, Microbial Sensitivity Tests, beta-Lactamases genetics, Bacteremia diagnosis, Bacteremia drug therapy, Anti-Infective Agents therapeutic use, Sepsis drug therapy
- Abstract
Importance: Our study addresses a significant issue in the medical and scientific community-the delayed administration of appropriate antimicrobial treatments due to the time-consuming process of phenotypic susceptibility data collection in gram-negative bloodstream infections. Our research indicates that a multiplex PCR rapid diagnostic test (RDT) significantly outperformed two clinical scoring tools in predicting ceftriaxone susceptibility. Multiplex PCR also led to reduced instances of undertreatment with ceftriaxone and minimized overtreatment with carbapenems. Furthermore, multiplex PCR demonstrated high sensitivity and specificity in predicting ceftriaxone susceptibility. The results of our study underscore the potential RDTs to reduce the time to appropriate antimicrobial therapy, leading to improved patient outcomes and reduced healthcare costs., Competing Interests: Tristan T. Timbrook is an employee and stockholder of BioMérieux. No other authors have any financial disclosures.
- Published
- 2024
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