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The analysis of non-Newtonian fluid flow over an oscillating surface often involves numerical simulations and experimental investigations. Computational fluid dynamics method including finite difference or finite element techniques can be used to crack the governing equations of the fluid flow. In this work, we used the Crank–Nicolson numerical technique to analyze the numerical behavior of unsteady boundary layer flow of Casson fluid with natural convection past an oscillating vertical plate. The temperature-dependent viscosity is assumed for the flow analysis. The impact of chemical reaction and heat generation coefficient is used to examine the mass and heat transferal rates. The investigation of non-Newtonian fluid flow over an oscillating surface is crucial for a wide range of industrial, biomedical, and scientific applications. The governing model of equations occurs in the form of nondimensional PDEs and then we use the dimensionless variables in order to achieve the dimensional PDEs. These equations are numerically solved by using the Crank–Nicolson technique. The Crank–Nicolson scheme is used because it has the ability to provide accurate and stable solutions and make it a valuable numerical technique in various scientific and engineering disciplines. The findings indicate the significance of numerous parameters on the mass, velocity and energy regions. The numerical outcomes of skin friction are observed due to fluid parameter, viscosity parameter, Grashof numbers of heat and solutal rates. [ABSTRACT FROM AUTHOR]