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• Lake evolution of Sumxi Co has been reconstructed from lacustrine carbonate isotopes. • Hydrological conditions were mainly dominated by regional precipitation on the northwestern QTP. • Millennial hydroclimate events were responding to globally cooling events and solar irradiance. Climatic and hydrological changes on the Qinghai-Tibetan Plateau (QTP) are controlled by the Asian summer monsoon and the mid-latitude westerlies, which directly affect a large population in Asia. However, the millennial temporal and spatial patterns of Holocene hydroclimate variations on the QTP remain unclear due to the lack of high-quality paleoclimatic records. This paper examines high-resolution stable oxygen and carbon isotopes of authigenic carbonate (δ18O carb and δ13C carb) covering the past 5,000 years taken from Sumxi Co, a hydrologically closed lake lies outside the direct influence of the large ice caps on the northwestern QTP. The hydrological environment of Sumxi Co inferred from the covariance between δ18O carb and δ13C carb values was unstable during the middle to late Holocene, with abrupt increases in lake-levels during the 5.0–4.0 cal ka BP, 3.2–3.1 cal ka BP, 1.8–1.3 cal ka BP, and 0.7 cal ka BP to present. Past millennial hydrological fluctuations coincide temporally with the occurrences of glacier advances on the northwestern QTP, implying increased regional moisture and precipitation during cold periods in the region. The 'cold and wet' hydroclimatic pattern is comparable in other records to the arid areas of central Asia dominated by westerlies before the current anthropogenic warming. The four millennial-scale humid events are synchronous with reduced solar irradiance within dating errors, supporting the hypotheses that the regional pattern of hydroclimatic evolution in arid central Asia responds dominantly and directly to changes in solar activity. This external forcing may be amplified by North Atlantic cooling events and southward shifts of the intertropical convergence, which have further modulated the position of mid-latitude westerlies and the strength of the Indian summer monsoon. [ABSTRACT FROM AUTHOR]