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Improving the fast-charging capabilities and energy storage capacity of electric vehicles presents a feasible strategy for mitigating the prevalent concern of range anxiety in the market. Nanostructure electrode materials play a crucial role in this process. However, the current method of preparation is arduous and yields restricted quantities. In view of this, we have devised an innovative approach that provides convenience and efficacy, facilitating the large-scale synthesis of CoS2 nanoparticles, which exhibited exceptional performance. When the current density was 1000 mA g−1, the discharging capacity reached 760 mAh g−1 after 400 cycles. Remarkably, even at an increased current density of 5000 mA g−1, the discharging capacity of CoS2 remained at 685.5 mAh g−1. The ultra-high performance could be attributed to the specific surface area, which minimized the diffusion distance of sodium-ions during the charging and discharging processes and mitigated the extent of structural damage. Our straightforward preparation techniques facilitate the mass production and present a novel approach for the development of cost-effective and high-performing anode materials for sodium-ion batteries. [ABSTRACT FROM AUTHOR]

• Epoxypropyl dimethydodecyl ammonium chloride (EPDDMAC) were grafted on γ-Al 2 O 3 particles. • α-Al 2 O 3 were coated with EVOH and modified with EPDDMAC. • Using the TIPS method, the alumina particles can be completely encapsulated with less polymer. • γ-Al 2 O 3 /EPDDMAC particles and α-Al 2 O 3 @EVOH/EPDDMAC particles showed great antimicrobial performance. Antimicrobial particles can inhibit or kill microorganisms, and have been widely used as antimicrobial filler in coatings and polymers. Herein, we present a facile method to prepare antimicrobial alumina particles by grafting epoxypropyl dimethydodecyl ammonium chloride (EPDDMAC) on γ-Al 2 O 3 or ethylene–vinyl alcohol copolymer (EVOH) coated α-Al 2 O 3.The results show that EPDDMAC can be grafted on γ-Al 2 O 3 or EVOH-coated α-Al 2 O 3 particles effectively, and the grafting rate rises with the increased EPDDMAC amount. The grafted composite particles exhibit excellent antibacterial properties against Escherichia coli and display great potential in antibacterial applications. [ABSTRACT FROM AUTHOR]

Colorectal cancer (CRC) ranks as the third most prevalent global malignancy, marked by significant metastasis and post-surgical recurrence, posing formidable challenges to treatment efficacy. The integration of oligonucleotides with chemotherapeutic drugs emerges as a promising strategy for synergistic CRC therapy. The nanoformulation, lipid nanoparticle (LNP), presents the capability to achieve co-delivery of oligonucleotides and chemotherapeutic drugs for cancer therapy. In this study, we constructed lipid nanoparticles, termed as LNP-I-V by microfluidics to co-deliver oligonucleotides miR159 mimics (VDX05001SI) and irinotecan (IRT), demonstrating effective treatment of CRC both in vitro and in vivo. The LNP-I-V exhibited a particle size of 118.67 ± 1.27 nm, ensuring excellent stability and targeting delivery to tumor tissues, where it was internalized and escaped from the endosome with a pH-sensitive profile. Ultimately, LNP-I-V significantly inhibited CRC growth, extended the survival of tumor-bearing mice, and displayed favorable safety profiles. Thus, LNP-I-V held promise as an innovative platform to combine gene therapy and chemotherapy for improving CRC treatment. [ABSTRACT FROM AUTHOR]