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Empathic qualitative methods have become emblematic of early Chicago sociology. Yet methods were not formalized through the early 20th century and empathy was not in usage as a term. Only at mid-20th century did methodological formalization in sociology begin to occur, and an additional quarter-century passed before writing about empathy in sociological methods began to crystallize. Nevertheless, a portion of early Chicago sociologists, assimilating pragmatist thought, established a framework for the deployment of empathic acumen. Because empathy involves understanding others, it is argued that it is central to the study of social life. The article contends that understanding empathy must be as central to the social scientist's knowledge as it is to the effective deployment of research methods: a competent quest to generate knowledge about social life is premised on empathy. To heighten awareness of empathy, an epistemology is necessary. To this end, the article examines empathy as situated by a set of organizational and historical conditions that account for its origin and ascendance as a prescriptive characteristic of sociological work. The author draws attention to the significance of suffering and suggests that its religious precepts are transmuted for the conditions under which sociology develops in turn-of-the-century Chicago., (© 2024 The Author(s). Journal of the History of the Behavioral Sciences published by Wiley Periodicals LLC.)