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This document is an editorial from the International Journal of Molecular Sciences titled "Pathology, Diagnosis, and Management of Sarcoma." The editorial discusses the challenges in investigating sarcoma due to its rarity and heterogeneity. It highlights recent advancements in understanding the molecular pathogenesis of sarcomas, including molecular genetic techniques and immunohistochemical markers. The editorial also presents research on specific types of sarcomas, such as osteosarcoma and Ewing's sarcoma, and explores potential therapeutic approaches for soft tissue sarcomas. Additionally, it discusses targeted protein degradation as a promising pharmacological modality for sarcoma treatment. Overall, the editorial provides valuable insights into the current understanding and management of sarcomas. [Extracted from the article]