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Assessing river water quality is crucial for human and ecological needs because of the deterioration of the river and escalated water pollution under the threats of anthropogenic activities. In order to assess river water quality, the Damodar River water was evaluated from the perspectives of spatio-temporal dynamics of ecological (organic pollution index or OPI and eutrophication index or EI), bacteriological (coliform count and comprehensive bathing water quality index or CBWQI), and overall water quality assessments (water quality index or WQI and comprehensive pollution index or CPI). The OPI reveals that 44.66% of water samples have heavy organic pollution; however, EI depicts that almost all water samples of Damodar River have severe eutrophication, especially in the pre- and post-monsoon seasons. Moreover, the fecal coliform count and CBWQI indicate the unsuitability of river water for bathing. The overall WQI portrays that 21.56%, 33.59%, and 22.47% of water samples have heavy pollution in pre-monsoon, monsoon, and post-monsoon, respectively. Moreover, 73.39% of water samples have low CPI indicating slight comprehensive pollution. This study also reveals that the pollution level in the Damodar River downstream of the Durgapur barrage is high among the other stations. The major reasons behind the severe contamination of Damodar River water are urban-industrial and agricultural effluents mixing into the river that lead to higher concentrations of BOD, DO, fecal coliform, COD, fluoride TSS, and turbidity in the river water. Thus, this study carries appreciated information on policy recommendations for the different stakeholders of the Damodar River basin including regional planners, agri-engineers, and ecological river engineers for sustainable river management. [ABSTRACT FROM AUTHOR]