14 results on '"ARBOGAST, KRISTY B."'
Search Results
2. Impaired Neuromotor Control During Gait in Concussed Adolescents—A Frequency Analysis.
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Jain, Divya, Graci, Valentina, Beam, Megan E., Master, Christina L., Prosser, Laura A., McDonald, Catherine C., and Arbogast, Kristy B.
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PHYSICAL therapy ,TASK performance ,CAUSAL models ,RESEARCH funding ,NEUROPHYSIOLOGY ,SCIENTIFIC observation ,HAMSTRING muscle ,GAIT disorders ,NEUROMUSCULAR system ,DIAGNOSIS ,GAIT in humans ,WEARABLE technology ,RETROSPECTIVE studies ,DESCRIPTIVE statistics ,TIBIALIS anterior ,NEUROLOGICAL disorders ,LONGITUDINAL method ,ELECTROMYOGRAPHY ,WALKING ,PSYCHOLOGY of movement ,COMPARATIVE studies ,BRAIN concussion ,COGNITION ,DISEASE complications ,ADOLESCENCE - Abstract
Disruptions in gait function are common after concussion in adolescents; however, the neuromotor control deficits driving these gait disruptions are not well known. Fifteen concussed (age mean [SD]): 17.4 [0.6], 13 females, days since injury: 26.3 [9.9]) and 17 uninjured (age: 18.0 [0.7], 10 females) adolescents completed 3 trials each of single-task gait and dual-task gait (DT). During DT, participants simultaneously walked while completing a serial subtraction task. Gait metrics and variability in instantaneous mean frequency in lower extremity muscles were captured by inertial sensors and surface electromyography, respectively. A 2-way analysis of covariance was used to compare gait metrics across groups and conditions. Functional principal components analysis was used to identify regions of variability in instantaneous mean frequency curves. Functional principal component scores were compared across groups using a Welch statistic. Both groups displayed worse performance on gait metrics during DT condition compared to single-task, with no differences between groups (P <.001). Concussed adolescents displayed significantly greater instantaneous mean frequency, indicated by functional principal component 1, in the tibialis anterior, biceps femoris, and semitendinosus (P <.05) during single-task and DT compared with uninjured adolescents. Our observations suggest that concussed adolescents display inefficient motor unit recruitment lasting longer than 2 weeks following injury, regardless of the addition of a secondary task. [ABSTRACT FROM AUTHOR]
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- 2024
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3. Head Injury Treatment With Healthy and Advanced Dietary Supplements: A Pilot Randomized Controlled Trial of the Tolerability, Safety, and Efficacy of Branched Chain Amino Acids in the Treatment of Concussion in Adolescents and Young Adults
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Corwin, Daniel J., primary, Myers, Sage R., additional, Arbogast, Kristy B., additional, Lim, Miranda M., additional, Elliott, Jonathan E., additional, Metzger, Kristina B., additional, LeRoux, Peter, additional, Elkind, Jaclynn, additional, Metheny, Hannah, additional, Berg, Jeffrey, additional, Pettijohn, Kevin, additional, Master, Christina L., additional, Kirschen, Matthew P., additional, and Cohen, Akiva S., additional
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- 2024
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4. Neurovascular Coupling in Acutely Concussed Adolescent Patients
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Roby, Patricia R., primary, Mozel, Anne E., additional, Grady, Matthew F., additional, Master, Christina L., additional, and Arbogast, Kristy B., additional
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- 2024
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5. Finite element brain deformation in adolescent soccer heading.
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Huber, Colin M., Patton, Declan A., Maheshwari, Jalaj, Zhou, Zhou, Kleiven, Svein, and Arbogast, Kristy B.
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SOCCER ,TEENAGERS ,SOFT tissue injuries - Abstract
Finite element (FE) modeling provides a means to examine how global kinematics of repetitive head loading in sports influences tissue level injury metrics. FE simulations of controlled soccer headers in two directions were completed using a human head FE model to estimate biomechanical loading on the brain by direction. Overall, headers were associated with 95th percentile peak maximum principal strains up to 0.07 and von Mises stresses up to 1450 Pa, and oblique headers trended toward higher values than frontal headers but below typical injury levels. These quantitative data provide insight into repetitive loading effects on the brain. [ABSTRACT FROM AUTHOR]
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- 2024
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6. Dose-Response Effect of Mental Health Diagnoses on Concussion Recovery in Children and Adolescents
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Master, Christina L., primary, Corwin, Daniel J., additional, Fedonni, Daniele, additional, Ampah, Steven B., additional, Housel, Kaitlyn C., additional, McDonald, Catherine, additional, Arbogast, Kristy B., additional, and Grady, Matthew F., additional
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- 2024
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7. Optimizing the Combination of Common Clinical Concussion Batteries to Predict Persistent Postconcussion Symptoms in a Prospective Cohort of Concussed Youth
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Corwin, Daniel J., primary, Mandel, Francesca, additional, McDonald, Catherine C., additional, Barnett, Ian, additional, Arbogast, Kristy B., additional, and Master, Christina L., additional
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- 2024
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8. Postinjury Outcomes After Non–Sport-Related Concussion: A CARE Consortium Study.
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Roby, Patricia R., Mozel, Anne E., Arbogast, Kristy B., Buckley, Thomas, Caccese, Jaclyn B., Chrisman, Sara P. D., Clugston, James R., Eckner, James T., Esopenko, Carrie, Hunt, Tamerah, Kelly, Louise A., McDevitt, Jane, Perkins, Susan M., Putukian, Margot, Susmarski, Adam, Broglio, Steven P., Pasquina, Paul F., McAllister, Thomas W., McCrea, Michael, and Master, Christina L.
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WOUNDS & injuries ,MENTAL health ,LOSS of consciousness ,SECONDARY analysis ,T-test (Statistics) ,RESEARCH funding ,SPORTS injuries ,SEX distribution ,MULTIPLE regression analysis ,TREATMENT effectiveness ,SYMPTOM burden ,DESCRIPTIVE statistics ,MOVEMENT disorders ,RELATIVE medical risk ,SEVERITY of illness index ,CHI-squared test ,LONGITUDINAL method ,SPORTS re-entry ,AMNESIA ,CONFIDENCE intervals ,COMPARATIVE studies ,EPIDEMIOLOGY ,DATA analysis software ,BRAIN concussion ,DISEASE complications ,SYMPTOMS - Abstract
Concussion research has primarily focused on sport-related mechanisms and excluded non–sport-related mechanisms. In adult populations, non–sport-related concussions (non-SRCs) demonstrated worse clinical outcomes compared with sport-related concussions (SRCs); however, investigations of non-SRCs in college-aged patients are limited. To examine clinical outcomes in collegiate athletes with non-SRCs compared with SRCs and explore sex differences in outcomes among collegiate athletes with non-SRCs. Prospective cohort study. Clinical setting. A total of 3500 athletes were included (n = 555 with non-SRCs, 42.5% female) from colleges or universities and service academies participating in the National Collegiate Athletic Association Department of Defense Concussion Assessment, Research and Education (CARE) Consortium. Dichotomous outcomes (yes or no) consisted of immediate reporting, mental status alterations, loss of consciousness, posttraumatic amnesia, retrograde amnesia, motor impairments, delayed symptom presentation, and required hospital transport. Continuous outcomes were symptom severity, days with concussion symptoms, and days lost to injury. Data were collected within 24 to 48 hours of injury and at return to play. Adjusted relative risks (ARRs) compared the likelihood of dichotomous outcomes by mechanism and by sex within patients with non-SRCs. Multivariate negative binomial regressions were used to assess group differences in continuous variables. Athletes with non-SRCs were less likely to report immediately (ARR = 0.73, 95% CI = 0.65, 0.81) and more likely to report delayed symptom presentation (ARR = 1.17, 95% CI = 1.03, 1.32), loss of consciousness (ARR = 3.15, 95% CI = 2.32, 4.28), retrograde amnesia (ARR = 1.77, 95% CI = 1.22, 2.57), and motor impairment (ARR = 1.45, 95% CI = 1.14, 1.84). Athletes with non-SRCs described greater symptom severity, more symptomatic days, and more days lost to injury (P <.001) compared with those who had SRCs. Within the non-SRC group, female athletes indicated greater symptom severity, more symptomatic days, and more days lost to injury (P <.03) than male athletes. Athletes with non-SRCs had worse postinjury outcomes compared with those who had SRCs, and female athletes with non-SRCs had worse recovery metrics than male athletes. Our findings suggest that further investigation of individuals with non-SRCs is needed to improve concussion reporting and management. [ABSTRACT FROM AUTHOR]
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- 2024
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9. The Variability of Recovery From Pediatric Concussion Using Multimodal Clinical Definitions.
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Corwin, Daniel J., Metzger, Kristina B., McDonald, Catherine C., Pfeiffer, Melissa R., Arbogast, Kristy B., and Master, Christina L.
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BRAIN concussion ,SPORTS re-entry ,DEFINITIONS ,RESEARCH personnel ,TERTIARY care ,MEDICAL personnel - Abstract
Background: While concussions are common pediatric injuries, a lack of agreement on a standard definition of recovery creates multiple challenges for clinicians and researchers alike. Hypothesis: The percentage of concussed youth deemed recovered as part of a prospective cohort study will differ depending on the recovery definition. Study Design: Descriptive epidemiologic study of a prospectively enrolled observational cohort Level of Evidence: Level 3. Methods: Participants aged 11 to 18 years were enrolled from the concussion program of a tertiary care academic center. Data were collected from initial and follow-up clinical visits ≤12 weeks from injury. A total of 10 recovery definitions were assessed: (1) cleared to full return to sports; (2) return to full school; (3) self-reported return to normal; (4) self-reported full return to school; (5) self-reported full return to exercise; (6) symptom return to preinjury state; (7) complete symptom resolution; (8) symptoms below standardized threshold; (9) no abnormal visio-vestibular examination (VVE) elements; and (10) ≤1 abnormal VVE assessments. Results: In total, 174 participants were enrolled. By week 4, 63.8% met at least 1 recovery definition versus 78.2% by week 8 versus 88.5% by week 12. For individual measures of recovery at week 4, percent recovered ranged from 5% by self-reported full return to exercise to 45% for ≤1 VVE abnormality (similar trends at 8 and 12 weeks). Conclusion: There is wide variability in the proportion of youth considered recovered at various points following concussion depending on the definition of recovery, with higher proportions using physiologic examination-based measures and lower proportions using patient-reported measures. Clinical Relevance: These results further emphasize the need for a multimodal assessment of recovery by clinicians as a single and standardized definition of recovery that captures the broad impact of concussion on a given patient continues to be elusive. [ABSTRACT FROM AUTHOR]
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- 2024
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10. Dose-Response Effect of Mental Health Diagnoses on Concussion Recovery in Children and Adolescents
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Watson, Andrew M., Master, Christina L., Corwin, Daniel J., Fedonni, Daniele, Ampah, Steven B., Housel, Kaitlyn C., McDonald, Catherine, Arbogast, Kristy B., and Grady, Matthew F.
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Background: Pre-existing mental health diagnoses may contribute to greater emotional symptom burden and prolonged recovery after concussion.Hypothesis: Youth with pre-existing mental health diagnoses will have greater emotional symptom burden, greater risk for delayed return to exercise, and more prolonged recovery from concussion than those without those diagnoses.Study Design: Prospective cohort.Level of Evidence: Level 3.Methods: A prospective registry of youth concussion was examined for differences in emotional symptom burden after injury to develop a predictive risk model for prolonged recovery. The impact of individual and total number of pre-existing mental health diagnoses (0, 1, 2, and 3+) was assessed, and multivariable logistic regression was performed to identify factors associated with prolonged recovery.Results: Among a cohort of 3105 youth with concussion, those with a history of mental health diagnoses, in a dose-response fashion, had greater postinjury emotional symptom burden (7 emotional symptoms vs 4; P< 0.01), visio-vestibular dysfunction (65% abnormal vs 56% abnormal; P< 0.01), later return to symptom-limited exercise (23 vs 21 days; P< 0.01), and overall longer concussion recovery (38 days, interquartile range [IQR] 18, 80) versus 25 days (IQR 13, 54; P< 0.01). Boys with prolonged recovery after concussion had greater emotional symptom burden than girls (5 emotional symptoms vs 3; P< 0.01).Conclusion: Pre-existing mental health diagnoses are associated with greater postinjury emotional symptom burden and longer concussion recovery in a dose-response fashion. Visiovestibular deficits and delayed return to exercise are also associated with pre-existing mental health diagnoses and prolonged recovery. Boys with prolonged recovery from concussion experience greater emotional symptom burden than girls.Clinical Relevance: Addressing pre-existing mental health diagnoses is essential to concussion management. Boys with prolonged recovery from concussion may particularly benefit from interventions to address their higher emotional symptom burden. Interventions, including a home visio-vestibular exercise program and symptom-limited exercise, may contribute to improving time to concussion recovery.
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- 2024
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11. Trajectory of Health-related Quality of Life Following Pediatric Concussion.
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Shoop J, Fedonni D, Daley MM, Master CL, Arbogast KB, and McDonald C
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Objectives: To assess changes in health-related quality of life (HRQOL) across a 12-month period following pediatric concussion and to explore whether psychological factors (ie, pre-injury mental health history, current symptoms of anxiety and depression, sleep disturbance, or grit) were associated with HRQOL., Study Design: Prospective cohort study design using data collected from patients presenting to a speciality care concussion program, with each patient followed for 12 months after initial presentation. Comparison data were collected from non-concussed controls recruited from the community. A total of 49 concussed patients (median=15.4 years of age) completed the Pediatric Quality of Life Inventory (PedsQL), Patient-Reported Outcome Measure Information Systems (PROMIS) Anxiety and Depressive Symptoms short forms, Pediatric Sleep Disturbance forms, and a Short Grit Scale. Mixed effects models explored change in HRQOL across time., Results: Total HRQOL at initial clinic presentation was significantly lower for concussed adolescents (Peds QL Total Score mean=72 [SD=16 ]) compared with non-concussed controls (mean=88 [SD=11], p <.001). HRQOL improved in the patients with concussion over a 6-month period after initial assessment with no significant changes thereafter. Pre-injury history of anxiety (coefficient= -11.388, CI=-18.49 - -4.28, p<0.001), current depressive symptoms (coefficient= -0.317, CI= -0.62 - -0.01, p<0.01), and sleep disturbance (coefficient=-0.336, CI=-0.71 - 0.04, p<0.05) all predicted lower HRQOL., Conclusions: HRQOL is significantly lower in the acute phase of pediatric concussion and steadily improves over the following 6 months. Psychological factors are linked to lower HRQOL and may serve as important indicators of risk for poor outcome., (Copyright © 2024 Elsevier Inc. All rights reserved.)
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- 2024
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12. Using mobile health to expedite access to specialty care for youth presenting to the emergency department with concussion at highest risk of developing persisting symptoms: a protocol paper for a non-randomised hybrid implementation-effectiveness trial.
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Corwin DJ, Godfrey M, Arbogast KB, Zorc JJ, Wiebe DJ, Michel JJ, Barnett I, Stenger KM, Calandra LM, Cobb J, Winston FK, and Master CL
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- Humans, Adolescent, Health Services Accessibility, Male, Female, Brain Concussion therapy, Emergency Service, Hospital, Telemedicine, Post-Concussion Syndrome therapy
- Abstract
Introduction: Paediatric concussion is a common injury. Approximately 30% of youth with concussion will experience persisting postconcussion symptoms (PPCS) extending at least 1 month following injury. Recently, studies have shown the benefit of early, active, targeted therapeutic strategies. However, these are primarily prescribed from the specialty setting. Early access to concussion specialty care has been shown to improve recovery times for those at risk for persisting symptoms, but there are disparities in which youth are able to access such care. Mobile health (mHealth) technology has the potential to improve access to concussion specialists. This trial will evaluate the feasibility of a mHealth remote patient monitoring (RPM)-based care handoff model to facilitate access to specialty care, and the effectiveness of the handoff model in reducing the incidence of PPCS., Methods and Analysis: This study is a non-randomised type I, hybrid implementation-effectiveness trial. Youth with concussion ages 13-18 will be enrolled from the emergency department of a large paediatric healthcare network. Patients deemed a moderate-to-high risk for PPCS using the predicting and preventing postconcussive problems in paediatrics (5P) stratification tool will be registered for a web-based chat platform that uses RPM to collect information on symptoms and activity. Those patients with escalating or plateauing symptoms will be contacted for a specialty visit using data collected from RPM to guide management. The primary effectiveness outcome will be the incidence of PPCS, defined as at least three concussion-related symptoms above baseline at 28 days following injury. Secondary effectiveness outcomes will include the number of days until return to preinjury symptom score, clearance for full activity and return to school without accommodations. The primary implementation outcome will be fidelity, defined as the per cent of patients meeting specialty care referral criteria who are ultimately seen in concussion specialty care. Secondary implementation outcomes will include patient-defined and clinician-defined appropriateness and acceptability., Ethics and Dissemination: This study was approved by the Institutional Review Board of the Children's Hospital of Philadelphia (IRB 22-019755). Study findings will be published in peer-reviewed journals and disseminated at national and international meetings., Trial Registration Number: NCT05741411., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
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- 2024
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13. Characteristics of Pediatric Concussion across Different Mechanisms of Injury in 5 through 12-Year-Olds.
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Roby PR, McDonald CC, Corwin DJ, Grady MF, Master CL, and Arbogast KB
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Objective: To investigate characteristics of sport-related concussion (SRC), recreation-related concussion (RRC), and nonsport or recreation-related concussion (non-SRRC) in patients 5 through 12 years old, an understudied population in youth concussion., Study Design: This observational study included patients aged 5 through 12 years presenting to a specialty care concussion setting at ≤28 days postinjury from 2018 through 2022. The following characteristics were assessed: demographics, injury mechanism (SRC, RRC, or SRRC), point of healthcare entry, and clinical signs and symptoms. Kruskal-Wallis and chi-square tests were used to assess group differences. Posthoc pairwise comparisons were employed for all analyses (α = 0.017)., Results: One thousand one hundred forty-one patients reported at ≤28 days of injury (female = 42.9%, median age = 11, interquartile range (IQR) = 9-12) with the most common mechanism being RRC (37.3%), followed by non-SRRC (31.9%). More non-SRRCs (39.6%) and RRC (35.7%) were first seen in the emergency department (P < .001) compared with SRC (27.9%). Patients with RRC and non-SRRC were first evaluated at specialists 2 and 3 days later than SRC (P < .001). Patients with non-SRRC reported with higher symptom burden, more frequent visio-vestibular abnormalities, and more changes to sleep and daily habits (P < .001) compared with RRC and SRC (P < .001)., Conclusions: In concussion patients 5 through 12 years, RRCs and non-SRRC were more prevalent than SRC, presenting first more commonly to the emergency department and taking longer to present to specialists. Non-SRRC had more severe clinical features. RRC and non-SRRC are distinct from SRC in potential for less supervision at time of injury and less direct access to established concussion health care following injury., Competing Interests: Declaration of Competing Interest This study was funded by the National Institute of Neurologic Disorders and Stroke of the National Institutes of Health under award numbers R01NS097549 (Christina Master and Kristy Arbogast) and T32NS043126 (Patricia Roby) and the Pennsylvania Department of Health. The authors declare no conflicts of interest. The funder/sponsor did not participate in the work., (Copyright © 2024 Elsevier Inc. All rights reserved.)
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- 2024
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14. Response Rate Patterns in Adolescents With Concussion Using Mobile Health and Remote Patient Monitoring: Observational Study.
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Ren S, McDonald CC, Corwin DJ, Wiebe DJ, Master CL, and Arbogast KB
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Background: A concussion is a common adolescent injury that can result in a constellation of symptoms, negatively affecting academic performance, neurobiological development, and quality of life. Mobile health (mHealth) technologies, such as apps for patients to report symptoms or wearables to measure physiological metrics like heart rate, have been shown to be promising in health maintenance. However, there is limited evidence about mHealth engagement in adolescents with a concussion during their recovery course., Objective: This study aims to determine the response rate and response rate patterns in concussed adolescents reporting their daily symptoms through mHealth technology. It will also examine the effect of time-, demographic-, and injury-related characteristics on response rate patterns., Methods: Participants aged between 11-18 years (median days since injury at enrollment: 11 days) were recruited from the concussion program of a tertiary care academic medical center and a suburban school's athletic teams. They were asked to report their daily symptoms using a mobile app. Participants were prompted to complete the Post-Concussion Symptom Inventory (PCSI) 3 times (ie, morning, afternoon, and evening) per day for 4 weeks following enrollment. The primary outcome was the response rate pattern over time (by day since initial app use and the day since injury). Time-, demographic-, and injury-related differences in reporting behaviors were compared using Mann Whitney U tests., Results: A total of 56 participants were enrolled (mean age 15.3, SD 1.9 years; n=32, 57% female). The median response rate across all days of app use in the evening was 37.0% (IQR 27.2%-46.4%), which was significantly higher than the morning (21.2%, IQR 15.6%-30.5%) or afternoon (26.4%, IQR 21.1%-31.5%; P<.001). The median daily response was significantly different by sex (female: 53.8%, IQR 46.2%-64.2% vs male: 42.0%, IQR 28.6%-51.1%; P=.003), days since injury to app use (participants starting to use the app >7 days since injury: 54.1%, IQR 47.4%-62.2% vs starting to use the app ≤7 days since injury: 38.0%, IQR 26.0%-53.3%; P=.002), and concussion history (participants with a history of at least one prior concussion: 57.4%, IQR 44.5%-70.5% vs participants without concussion history: 42.3%, IQR 36.8%-53.5%; P=.03). There were no significant differences by age. Differences by injury mechanism (sports- and recreation-related injury: 39.6%, IQR 36.1%-50.4% vs non-sports- or recreation-related injury: 30.6%, IQR 20.0%-42.9%; P=.04) and initial symptom burden (PCSI scores greater than the median score of 47: 40.9%, IQR 35.2%-53.8% vs PCSI scores less than or equal to the median score: 31.9%, IQR 24.6%-40.6%; P=.04) were evident in the evening response rates; however, daily rates were not statistically different., Conclusions: Evening may be the optimal time to prompt for daily concussion symptom assessment among concussed adolescents compared with morning or afternoon. Multiple demographic- and injury-related characteristics were associated with higher daily response rates, including for female participants, those with more than 1 week from injury to beginning mHealth monitoring, and those with a history of at least one previous concussion. Future studies may consider incentive strategies or adaptive digital concussion assessments to increase response rates in populations with low engagement., (© Sicong Ren, Catherine C McDonald, Daniel J Corwin, Douglas J Wiebe, Christina L Master, Kristy B Arbogast. Originally published in JMIR Pediatrics and Parenting (https://pediatrics.jmir.org).)
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- 2024
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