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El objetivo de este estudio fue analizar las barreras y facilitadores que los estudiantes con discapacidad manifiestan en Educación Física y en el deporte en Chile, Colombia, España y Perú. Se diseñó un estudio de tipo exploratorio, correlacional y de alcance transversal donde participaron 362 niñas, niños y adolescentes con discapacidad de Chile (41.1 %), Colombia (14.6 %), España (11.6 %) y Perú (32.5 %), a quienes se les aplicó el cuestionario “Barriers and facilitators of sports in children with physical disabilities” (BaFSCH) en su versión traducida al español. Respecto a los resultados, el 72.7 % practica actividad física en la escuela, con una mayor tendencia en Colombia (88.7 % χ² = 11.17, p = .02), donde el 72.0 % lo hace en clase de Educación Física mientras que el 38 %, en talleres de actividad física y deporte. Los principales facilitadores de inclusión son los padres y tutores, junto a sus amistades en el espacio escolar, y las barreras se asocian a algún accidente o caída, y/o su discapacidad y/o deficiencia. A su vez, el sexo biológico (OR = 1.893, IC = 1.19-3.00, p = .007) se asocia a un facilitador para la práctica de la actividad física, mientras que ser estudiante con discapacidad intelectual (OR = .437, IC = .20 – .94, p = .03) y discapacidad física (OR = .298, IC = .15-.58, p = .0002) se asocia a una barrera para la inclusión. Con esta investigación se reveló que la clase de Educación Física es fundamental en la práctica de la actividad física en el espacio educativo para niñas, niños y adolescentes con discapacidad, al igual que el entorno, que se transforma en factor protector a nivel ambiental.

This research, portion of monographic work presented in 2022, aims to discuss the relationship between religion and the constitution of a specific social functionality. Religious knowledge, essential for the social organization of different subjects over time, is sometimes devalued in contrast to other forms of knowledge, however, such research seeks to foster theoretical arguments for a discussion about religious themes and the ontological foundation of the world , the construction of representative modelsand a sacred orientation for everyday life. Throughout the text, a historiographic survey will follow in search of an adequate theoretical conceptualization with regard to the religious phenomenon and its social and historical aspect, in addition to a brief presentation of the relevance of the religious phenomenon throughout history and its subsequent contestation by other areas of knowledge

Abstract Background The quality of cotton fiber determines its value in the textile market, influencing agricultural profitability and the efficiency of textile processing. The selection of genotypes with superior fibers is a key factor for genetic improvement programs seeking adaptability and sustainability in the face of climate change. This demonstrates the strategic importance of this plant for sustainable agriculture and the global textile industry. The objective of this research was to decipher the fiber quality of Gossypium barbadense var. brasiliensis in the native Amazonian communities of La Convención, Cusco-Perú, and to evaluate other critical aspects of native cotton that have not yet been identified. The methodology included non-probability sampling for accessibility, qualitative and quantitative analyses, and multivariate analyses. The fiber length (mm), micronaire index (maturity/fineness), fiber strength (gf/tex), length uniformity index (%), fiber elongation (%), maturation index (%), and short fiber index (%) were the fiber characteristics evaluated using the HVI method in cotton genotypes. Results Cotton accessions collected from Koribeni (Gossypium spp.) and Shivankoreni (Gossypium barbadense var. brasiliensis) stood out for their fiber quality properties, especially length, strength, and uniformity, which highlights their relevance for advanced textile applications and potential for use in plant genetic improvement programs. Conclusion These findings reinforce the need to conserve and study these native cotton accessions from the Peruvian Amazon region, which can offer promising perspectives for the textile industry and agricultural biodiversity.

In rural-urban interface areas exposed to wildfires, it is essential that territorial planning be adapted to integrate risk reduction measures. However, few studies have examined the historical interactions between wildfire management and territorial planning, and how their institutions and instruments have adapted to increase their integrated over time. Accordingly, the aim of this research is to examine the evolution of the Chilean territorial planning system in its incorporation of wildfire risk management measures. A qualitative case study analysis strategy is used. A chronology of Chilean territorial planning and its integration of wildfires characterized in five periods is presented. Progressive efforts to improve the way in which territorial planning addresses wildfires are evidenced, however, characteristics of the historical context condition and limit its ability to do so. This research contributes to the understanding of the Chilean planning system and its relationship with wildfires, contributing to the international discussion on the factors that condition the integration of disaster risk reduction policies in various contexts.

Abstract Sickle cell disease is a devastating blood disorder that originates from a single point mutation in the HBB gene coding for hemoglobin. Here, we develop a GMP-compatible TALEN-mediated gene editing process enabling efficient HBB correction via a DNA repair template while minimizing risks associated with HBB inactivation. Comparing viral versus non-viral DNA repair template delivery in hematopoietic stem and progenitor cells in vitro, both strategies achieve comparable HBB correction and result in over 50% expression of normal adult hemoglobin in red blood cells without inducing β-thalassemic phenotype. In an immunodeficient female mouse model, transplanted cells edited with the non-viral strategy exhibit higher engraftment and gene correction levels compared to those edited with the viral strategy. Transcriptomic analysis reveals that non-viral DNA repair template delivery mitigates P53-mediated toxicity and preserves high levels of long-term hematopoietic stem cells. This work paves the way for TALEN-based autologous gene therapy for sickle cell disease.

The Messinian-Zanclean boundary in the Mediterranean basin marks the end of the Messinian salinity crisis (MSC) at approximately 5.33 Ma. The mechanism behind the return to normal marine conditions after the MSC are debated, with two main hypotheses proposed: an instantaneous reflooding of the Mediterranean at the base of the Zanclean, following its near-complete desiccation, or a gradual sea level rise in a non-desiccated basin during the late MSC phase (Lago-Mare). Our objectives are to refine the age model of the Pollenzo section in the Piedmont basin, Italy, and to elucidate environmental variability during this phase. We employ high-resolution biomagnetostratigraphic and cyclostratigraphic analyses, integrated with statistical multivariate and cluster analyses, and tie the results with other Italian Mediterranean reference sections of the basal Zanclean. The proposed age model is based on biostratigraphic markers (planktic foraminifera and calcareous nannofossils), alongside the identification of the base of the Thvera subchron. Although no astrochronological tuning was proposed, the influence of orbital parameters variation on calcareous plankton was noted, especially at tie of eccentricity maxima. Our results indicate a gradual restoration of open marine conditions after the MSC, spanning from 5.33 to 5.23 Ma. We observe a transition from a more marginal environment to more open marine conditions at the termination of MSC. Our findings challenge the notion of an abrupt transition at the end of the MSC, emphasizing the gradual nature of environmental change in the northernmost Mediterranean basin, from the late Messinian to the early Zanclean.

Abstract In this work, the passivation and localized corrosion of selective laser melted (SLM) stainless steel 316 L when exposed to high pressures of CO2 with the presence of H2S and Cl− at 25 °C and 125 °C were studied. Depletion of Cr/Mo was observed at the cell interiors and melt-pool boundaries (MPBs) compared to the cell boundaries. Volta potential differences obtained from scanning Kelvin probe force microscopy (SKPFM) showed that the MPBs were 8–20 mV lower than the matrix, while the cell interiors were 20–50 mV lower than the cell boundaries. Electrochemical impedance spectroscopy (EIS) and Mott–Schottky tests indicated a more defective passive film at 125 °C, and X-ray photoelectron spectroscopy (XPS) confirmed the formation of a less protective film with an increased S/O ratio at 125 °C than 25 °C. Initiation of localized corrosion was observed at the MPBs and pits formed after a week of immersion were wider by an order of magnitude at 125 °C than 25 °C, with evidence of cell-interior dissolution. While passivity was observed even at elevated temperatures, local chemical heterogeneities compromised the stability of the film and contributed to localized corrosion in SLM SS316L.

Television broadcasts around the world employ specific hashtags to facilitate viewer engagement via social media with program hosts. In the context of news broadcasts, individuals' comments mix with the articles shown on television news, mainly in relation to urban situations. These social media posts constitute a significant database, as users assume roles similar to those of citizens. The aim of this paper is to scrutinize the posts associated with the hashtags #VcNoJL1 and #VcNoJL2, publishe on the Twitter (X) platform, in the context of the TV news program TV Liberal, broadcast in the State of Pará (Brazil), using the CRISP-DM methodology and data science techniques. Using a statistical examination of these publications, a discreet level of engagement was observed among viewers, who are also users of the aforementioned social media platform. Furthermore, a sentiment assessment of the posts was carried out, revealing that 54% of the comments are negative, 31% are positive and 15% are neutral. The negative comments notably highlight the challenges within municipal public administration, while the positive comments are around commemorative occasions such as Mother's Day and Grandparents' Day. This type of analysis constitutes an important monitoring tool not only for the television program, but also for public administration.

Abstract The fiber quality of cotton (Gossypium barbadense L.) native to the Peruvian Amazon region is one of the most versatile and essential natural fibers in the Peruvian textile industry. There is little information about the fiber quality traits of cotton genotypes native to the Peruvian Amazon region. This study investigated the fiber quality traits of Peruvian Pima cotton accessions native to the Amazon region of the La Convención Province, Cusco, Peru, to determine the lines with the greatest potential for improving fiber quality in cotton genetic breeding programs. A total of 14 cotton accessions with white fiber color, being 12 accessions of G. barbadense L. (Pima cotton) and two accessions of Gossypium sp. (unknown cotton), were analyzed. The fiber properties determined using the high volume instrument method included seven characteristics. All fiber properties were classified into five quality classes. The data on fiber quality properties were subjected to distribution, correlation, and canonical variable analysis. The results of fiber quality properties showed that the two accessions of Gossypium sp. (unknown cotton) can be promising options to be used as high‐quality fiber progenies in crop genetic breeding programs or can be cultivated by regional farmers for the purpose of producing cotton with high fiber quality. Future investigations could utilize other methods of fiber quality analysis and compare the fiber quality of these cotton accessions native to the Peruvian Amazon region with other cotton species grown worldwide to improve the understanding of Pima cotton fiber quality and its applicability in different contexts of the textile industries.

El presente artículo discute los avances y desafíos de las tecnologías de monitorización en salud de personas mayores y sus implicaciones en la privacidad y confidencialidad de los datos recolectados. Se trata de un estudio exploratorio, fundamentado en la literatura, con síntesis narrativa. El texto contextualiza las demandas derivadas del envejecimiento poblacional y el uso de sensores y otros dispositivos electrónicos en la monitorización de actividades diarias de personas mayores en ambientes internos y externos. Es importante resaltar que los beneficios ofrecidos por las tecnologías no deben comprometer la privacidad y confidencialidad de los datos. Para garantizar esto, es necesario mejorar los mecanismos reguladores, estableciendo estándares de seguridad y principios éticos para la protección de datos personales, respetando la privacidad y confidencialidad de los datos.

Abstract The use of hydrogels helpsthe production of plants in drought-stress environments. Thus, this work evaluated using different hydrogels to minimize drought stress in soybean cultivation. The treatments employed two different hydrogels, one already commercialized and the other produced with cashew gum (Anacardium occidentale), five levels (0, 30, 60, 120, and 240 mg pot−1) of the hydrogels, and two levels of drought stress in sandy soil. The growth and yield of soybeans and the levels of macro- and micronutrients in soybeans were evaluated.growth. The use of CG hydrogel promoted 12% increase in protein content in the seeds in the when soybean plants were subjected to drought stress. The levels of 30 mg pot-1, corresponding to 7.5 kg ha−1, improved the ’morphological and productive parametersof the soybeans. The increasing levels of hydrogel promoted the increase in P, K, Ca, Mg, and Fe and reduced S and Cu on an exponential scale. The use of cashew gum hydrogel increased the K and Ca contents in soybean seeds compared to commercial hydrogel.

Purpose. The aim of the study is to describe the genotype and phenotype of a Mexican cohort with PCARE-related retinal disease. Methods. The study included 14 patients from 11 unrelated pedigrees with retinal dystrophies who were demonstrated to carry biallelic pathogenic variants in PCARE. Visual assessment methods included best corrected visual acuity, color fundus photography, Goldmann visual field test, kinetic perimetry, dark/light adapted chromatic perimetry, full-field electroretinography, autofluorescence imaging, and spectral domain-optical coherence tomography imaging. Genetic screening was performed either by gene panel sequencing or by exome sequencing. Results. According to the results of multimodal imaging and functional tests, all 14 patients were diagnosed with cone-rod dystrophy. Six different PCARE pathogenic alleles were identified in our cohort, including three novel mutations: c.3048_3049del (p.Tyr1016∗), c.3314_3315del (p.Ser1105∗), and c.551A > G (p.His184Arg). Notably, alleles p.His184Arg, p.Arg613∗, and p.Arg984∗ were present in 18 of the 22 (82%) PCARE alleles from probands in our cohort. Conclusion. Our work expands the PCARE mutational profile by identifying three novel pathogenic variants causing retinal dystrophy. While phenotypic variations occurred among patients, a cone-rod dystrophy pattern was observed in all affected individuals.

Objective When considering proposals to improve diets, it is important to understand how factors like price and income can affect saturated fat (SF) intake and demand. In this study, we examine and estimate the influence of price and income on intake across 160 countries, by age and sex, and derive sensitivity measures (price elasticities) that vary by age, sex and world region.Design We econometrically estimate intake responsiveness to income and prices across countries, accounting for differences by world region, age and sex. Intake data by age, sex and country were obtained from the 2018 Global Dietary Database. These data were then linked to global price data for select food groups from the World Bank International Comparison Programme and income data from the World Development Indicators Databank (World Bank).Results Intake differences due to price were highly significant, with a 1% increase in price associated with a lower SF intake (% energy/d) of about 4.3 percentage points. We also find significant differences across regions. In high-income countries, median (age 40) intake reductions were 1.4, 0.8 and 0.2 percentage points, given a 1% increase in the price of meat, dairy, and oils and fats, respectively. Price elasticities varied with age but not sex. Intake differences due to income were insignificant when regional binary variables were included in the analysis.Conclusion The results of this study show heterogeneous associations among prices and intake within and across countries. Policymakers should consider these heterogeneous effects as they address global nutrition and health challenges.

BackgroundFrailty is characterised by a reduced resilience to adversity. In this analysis we examined changes in frailty in people aged 50+ before and during a period of austere public spending in England.MethodsData from the English Longitudinal Study of Ageing 2002-2018 were analysed. Associations between austerity and frailty were examined using (1) Multilevel interrupted times series analysis (ITSA); and (2) Accelerated longitudinal modelling comparing frailty trajectories in people of the same age in 2002 and 2012.ResultsThe analysis included 16,410 people (mean age 67 years, 55% women), with mean frailty index score of 0.16. Mean scores in women (0.16) where higher than in men (mean 0.14), and higher in the poorest tertile (mean 0.20) than the richest (mean 0.12). In the ITSA, frailty index scores increased more quickly during austerity than before, with the additional increase in frailty 2012-2018 being similar in magnitude to the difference in mean frailty score between people aged 65-69 and 70-74 years. Steeper increases in frailty after 2012 were experienced across the wealth-spectrum and in both sexes but were greater in the very oldest (80+). In the accelerated longitudinal analysis, frailty was lower in 2012 than 2002, but increased more rapidly in the 2012 cohort compared to the 2002 cohort; markedly so in people aged 80+.ConclusionThe period of austerity politics was associated with steeper increases in frailty with age compared to the pre-austerity period, consistent with previously observed increases in mortality.