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Your search keyword '"Alvarez, Enrique"' showing total 23 results
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23 results on '"Alvarez, Enrique"'

1. When does General Relativity become linear?

Author

Álvarez, Enrique and Anero, Jesús

Subjects
General Relativity and Quantum Cosmology, High Energy Physics - Theory
Abstract

Nilpotent deformations of an arbitrary background spacetime are considered . Those are of the form $\bg_{\m\n}+ l_\m l_\n$ with $l^2=0$. The relationship between the Ricci tensor of the background metric and the Ricci tensor of the deformed metric is found exactly. It consists of two terms. one is essentially the Fierz-Pauli operator, and the other is new. When the background is flat, the Kerr-Schild family is recovered. Novel examples (even including some simple sources) for more general backgrounds are discussed., Comment: Latex 13 pages,comments added, title changed

Published
2024

2. Superposition of gravitational fields

Author

Álvarez, Enrique and Anero, Jesús

Subjects
General Relativity and Quantum Cosmology, High Energy Physics - Theory
Abstract

Linear superposition of gravitational fields is shown to be possible for a large class of spacetimes, in some specific coordinates. Explicit examples are presented., Comment: 11 pages, LaTeX, more details given

Published
2024

3. Gravitons in a gravitational plane wave

Author

Alvarez, Enrique, Anero, Jesus, and Sanchez-Ruiz, Irene

Subjects
High Energy Physics - Theory
Abstract

Gravitational plane waves (when Ricci flat) belong to the VSI family. The achronym VSI stands for vanishing scalar invariants, meaning that all scalar invariants built out of Riemann tensor and its derivatives vanish, although the Riemann tensor itself does not. In the particular case of plane waves many interesting phenomena have been uncovered for strings propagating in this background. Here we comment on gravitons propagating in such a spacetime, which itself presumably consists of an Avogadro number of such gravitons., Comment: 17 pages, LaTeX

Published
2024

4. Correlation between breast cancer subtypes determined by immunohistochemistry and n-COUNTER PAM50 assay: a real-world study

Author

Lopez-Tarruella, Sara, Del Monte-Millán, María, Roche-Molina, Marta, Jerez, Yolanda, Echavarria Diaz-Guardamino, Isabel, Herrero López, Blanca, Gamez Casado, Salvador, Marquez-Rodas, Iván, Alvarez, Enrique, Cebollero, María, Massarrah, Tatiana, Ocaña, Inmaculada, Arias, Ainhoa, García-Sáenz, José Ángel, Moreno Anton, Fernando, Olier Garate, Clara, Moreno Muñoz, Diana, Marrupe, David, Lara Álvarez, Miguel Ángel, Enrech, Santos, Bueno Muiño, Coralia, and Martín, Miguel

Published
2024
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5. Feasibility of Low-Load Resistance Training Using Blood Flow Restriction for People With Advanced Multiple Sclerosis: A Prospective Cohort Study

Author

Manago, Mark M., Cohen, Evan T., Alvarez, Enrique, Hager, Emily R., Owens, Johnny G., and Bade, Michael

Subjects
Multiple sclerosis -- Care and treatment, Therapeutics, Physiological -- Methods, Physical therapy -- Methods, Strengthening exercises -- Methods, Health
Abstract

Objective. The objective of this study was to determine the feasibility of low-load resistance training with blood flow restriction (BFR) for people with advanced disability due to multiple sclerosis (MS). Methods. In this prospective cohort study, 14 participants with MS (Expanded Disability Status Scale [EDSS] score = 6.0 to 7.0; mean age = 55.4 [SD = 6.2] years; 71% women) were asked to perform 3 lower extremity resistance exercises (leg press, calf press, and hip abduction) bilaterally twice weekly for 8 weeks using BFR. Feasibility criteria were as follows: enrollment of 20 participants, [greater than or equal to] 80% retention and adherence, [greater than or equal to] 90% satisfaction, and no serious adverse events related to the intervention. Other outcomes included knee extensor, ankle plantar flexor, and hip abductor muscle strength, 30-Second Sit-to-Stand Test, Berg Balance Scale, Timed 25-Foot Walk Test, 12-Item MS Walking Scale, Modified Fatigue Impact Scale, Patient-Specific Functional Scale, and daily step count. Results. Sixteen participants consented, and 14 completed the intervention, with 93% adherence overall. All participants were satisfied with the intervention. A minor hip muscle strain was the only intervention-related adverse event. There were muscle strength improvements on the more-involved (16%-28%) and less-involved (12%-19%) sides. There were also changes in the 30-Second Sit-to-Stand Test (1.9 repetitions; 95% CI = 1.0 to 2.8), Berg Balance Scale (5.3 points; 95% CI = 3.2 to 7.4), Timed 25-Foot Walk Test (-3.3 seconds; 95% CI = -7.9 to 1.3), Modified Fatigue Impact Scale (-8.8 points; 95% CI = -16.5 to -1.1), 12-Item MS Walking Scale (-3.6 points; 95% CI = -11.5 to 4.4), Patient-Specific Functional Scale (2.9 points; 95% CI = 1.9 to 3.8), and daily step count (333 steps; 95% CI = -191 to 857). Conclusion. Low-load resistance training using BFR in people with MS and EDSS scores of 6.0 to 7.0 appears feasible, and subsequent investigation into its efficacy is warranted. Impact. Although efficacy data are needed, combining BFR with low-load resistance training may be a viable alternative for people who have MS and who do not tolerate conventional moderate- to high-intensity training because of more severe symptoms, such as fatigue and weakness. Lay Summary. Low-load strength training with BFR was feasible in people who have advanced disability due to MS. Using BFR may provide an alternative for people with MS who do not tolerate higher intensity training due to more severe symptoms, such as fatigue and weakness. Keywords: Blood Flow Restriction, Feasibility, Low-Load Resistance Training, Multiple Sclerosis, Introduction Multiple sclerosis (MS) is an autoimmune condition that causes demyelination and axonal death in the central nervous system, and can result in a variety of symptoms depending on lesion [...]

Published
2024
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10. Prognostic Value of Serum Neurofilament Light Chain for Disease Activity in Patients with Relapsing Multiple Sclerosis: Results from Subgroup Analysis Based on Body Mass Index and Age from the Phase 3 ASCLEPIOS I/II Trials (P6-6.011)

Author

Cross, Anne, primary, Ziemssen, Tjalf, additional, Arnold, Douglas, additional, Thouvenot, Eric, additional, Zamvil, Scott, additional, Bhatt, Alit, additional, Wei, Wenjia, additional, Boer, Ibolya, additional, Alvarez, Enrique, additional, and Wiendl, Heinz, additional

Published
2024
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11. Multi-institutional Study of Neurologic Outcomes in People with Multiple Sclerosis Who Are Treated with Immune Checkpoint Inhibitors for Oncologic Indications (PL4.004)

Author

Quinn, Carson, primary, Rajarajan, Prashanth, additional, Kopinsky, Hannah, additional, Wolf, Andrew, additional, De Camargo, Celeste Soares, additional, Gill, Alexander, additional, Murray, Joseph, additional, Probasco, John, additional, Galetta, Kristin, additional, Kantor, Daniel, additional, Coyle, Patricia, additional, Bhise, Vikram, additional, Alvarez, Enrique, additional, Conway, Sarah, additional, Bhattacharyya, Shamik, additional, and Kister, Ilya, additional

Published
2024
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13. Prognostic Value of On-treatment Serum Neurofilament Light Chain for New or Enlarging T2 Lesions in People with Relapsing Multiple Sclerosis: Pooled Analysis of the ASCLEPIOS I/II Trials (S42.003)

Author

Leist, Thomas, primary, Hauser, Stephen, additional, Derfuss, Tobias, additional, Wiendl, Heinz, additional, Arnold, Douglas, additional, Montalban, Xavier, additional, Bhatt, Alit, additional, Wei, Wenjia, additional, Boer, Ibolya, additional, Alvarez, Enrique, additional, and Ziemssen, Tjalf, additional

Published
2024
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15. Ofatumumab Reduces Clinical and Radiological Activity in People with Recently Diagnosed Treatment-naive Relapsing Multiple Sclerosis Irrespective of Baseline Serum Neurofilament Light Chain Levels (P9-6.008)

Author

Pardo, Gabriel, primary, Kappos, Ludwig, additional, Cross, Anne, additional, Kuhle, Jens, additional, Montalban, Xavier, additional, Khachanova, Natalia, additional, Bhatt, Alit, additional, Piccolo, Rebecca, additional, Xi, Jing, additional, Boer, Ibolya, additional, Arnold, Douglas, additional, Alvarez, Enrique, additional, and Ziemssen, Tjalf, additional

Published
2024
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23. Senescent-like microglia limit remyelination through the senescence associated secretory phenotype.

Author

Gross PS, Laforet VD, Manavi Z, Zia S, Lee SH, Shults N, Selva S, Alvarez E, Plemel JR, Schafer DP, and Huang JK

Abstract

The capacity to regenerate myelin in the central nervous system (CNS) diminishes with age. This decline is particularly evident in multiple sclerosis (MS), which has been suggested to exhibit features of accelerated biological aging. Whether cellular senescence, a hallmark of aging, contributes to remyelination impairment remains unknown. Here, we show that senescent cells (SCs) accumulate within demyelinated lesions after injury, and their elimination enhances remyelination in young mice but not in aged mice. In young mice, we observed the upregulation of senescence-associated transcripts primarily in microglia after demyelination, followed by their reduction during remyelination. However, in aged mice, senescence-associated factors persisted within lesions, correlating with inefficient remyelination. We found that SC elimination enhanced remyelination in young mice but was ineffective in aged mice. Proteomic analysis of senescence-associated secretory phenotype (SASP) revealed elevated levels of CCL11/Eotaxin-1 in lesions, which was found to inhibit efficient oligodendrocyte maturation. These results suggest therapeutic targeting of SASP components, such as CCL11, may improve remyelination in aging and MS.

Published
2024
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