1. Pentamethine cyanine dyes with alkynyl group as perspective structure for conjugation with targeting moiety.
- Author
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Uspenskaia AA, Doroshenko IA, Popovicheva KA, Shmychkov NV, Pryakhina EV, Shafikov RR, Skvortsov DA, Beklemishev MK, Zaborova OV, Podrugina TA, Machulkin AE, and Beloglazkina EK
- Subjects
- Humans, Cycloaddition Reaction, Glutamate Carboxypeptidase II metabolism, Glutamate Carboxypeptidase II antagonists & inhibitors, Molecular Structure, Antigens, Surface metabolism, Antigens, Surface chemistry, Azides chemistry, Male, Prostatic Neoplasms drug therapy, Ligands, Carbocyanines chemistry, Carbocyanines chemical synthesis, Fluorescent Dyes chemistry, Fluorescent Dyes chemical synthesis, Alkynes chemistry, Alkynes chemical synthesis
- Abstract
We report a modified carbocyanine-based asymmetric fluorescent dye, suitable for the azide-alkyne cycloaddition reaction, that possesses promising photochemical properties (Φ
fl = 0,49). As an example of usage of the new fluorophore, it was conjugated to a ligand targeting prostate-specific membrane antigen (PSMA), one of the widely utilized prostate cancer markers., Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Anastasiia A. Uspenskaia reports financial support was provided by Russian Science Foundation. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)- Published
- 2025
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