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This document is an editorial on the special issue titled "Artificial Intelligence in Image-Based Screening, Diagnostics, and Clinical Care." It discusses the importance of integrating AI into healthcare, particularly in the areas of medical imaging and natural language processing. The editorial highlights the challenges of incorporating AI into clinical workflows, such as data quality and limited availability of training data. The special issue features 12 research studies that explore various AI methodologies in fields such as cardiac diagnostics, chest X-ray analysis, and oncology. The studies demonstrate the potential of AI to improve precision medicine, diagnostic accuracy, and clinical workflows. The editorial concludes by calling for continued research and collaboration to ensure the ethical and equitable development and deployment of AI in healthcare. [Extracted from the article]

The success of deep-learning algorithms in analyzing complex structured and unstructured multidimensional data has caused an exponential increase in the amount of research devoted to the applications of artificial intelligence (AI) in medicine in the past decade. Public release of large language models like ChatGPT the past year has generated an unprecedented storm of excitement and rumors of machine intelligence finally reaching or even surpassing human capability in detecting meaningful signals in complex multivariate data. Such enthusiasm, however, is met with an equal degree of both skepticism and fear over the social, legal, and moral implications of such powerful technology with relatively little safeguards or regulations on its development. The question remains in medicine of how to harness the power of AI to improve patient outcomes by increasing the diagnostic accuracy and treatment precision provided by medical professionals. Military medicine, given its unique mission and resource constraints,can benefit immensely from such technology. However, reaping such benefits hinges on the ability of the rising generations of military medical professionals to understand AI algorithms and their applications. Additionally, they should strongly consider working with them as an adjunct decision-maker and view them as a colleague to access and harness relevant information as opposed to something to be feared. Ideas expressed in this commentary were formulated by a military medical student during a two-month research elective working on a multidisciplinary team of computer scientists and clinicians at the National Library of Medicine advancing the state of the art of AI in medicine. A motivation to incorporate AI in the Military Health System is provided, including examples of applications in military medicine. Rationale is then given for inclusion of AI in education starting in medical school as well as a prudent implementation of these algorithms in a clinical workflow during graduate medical education. Finally, barriers to implementation are addressed along with potential solutions. The end state is not that rising military physicians are technical experts in AI; but rather that they understand how they can leverage its rapidly evolving capabilities to prepare for a future where AI will have a significant role in clinical care. The overall goal is to develop trained clinicians that can leverage these technologies to improve the Military Health System. [ABSTRACT FROM AUTHOR]

Novel screening and diagnostic tests based on artificial intelligence (AI) image recognition algorithms are proliferating. Some initial reports claim outstanding accuracy followed by disappointing lack of confirmation, including our own early work on cervical screening. This is a presentation of lessons learned, organized as a conceptual step-by-step approach to bridge the gap between the creation of an AI algorithm and clinical efficacy. The first fundamental principle is specifying rigorously what the algorithm is designed to identify and what the test is intended to measure (eg, screening, diagnostic, or prognostic). Second, designing the AI algorithm to minimize the most clinically important errors. For example, many equivocal cervical images cannot yet be labeled because the borderline between cases and controls is blurred. To avoid a misclassified case-control dichotomy, we have isolated the equivocal cases and formally included an intermediate, indeterminate class (severity order of classes: case>indeterminate>control). The third principle is evaluating AI algorithms like any other test, using clinical epidemiologic criteria. Repeatability of the algorithm at the borderline, for indeterminate images, has proven extremely informative. Distinguishing between internal and external validation is also essential. Linking the AI algorithm results to clinical risk estimation is the fourth principle. Absolute risk (not relative) is the critical metric for translating a test result into clinical use. Finally, generating risk-based guidelines for clinical use that match local resources and priorities is the last principle in our approach. We are particularly interested in applications to lower-resource settings to address health disparities. We note that similar principles apply to other domains of AI-based image analysis for medical diagnostic testing. [ABSTRACT FROM AUTHOR]

Background: Large vision models (LVM) pretrained by large datasets have demonstrated their enormous capacity to understand visual patterns and capture semantic information from images. We proposed a novel method of knowledge domain adaptation with pretrained LVM for a low-cost artificial intelligence (AI) model to quantify the severity of SARS-CoV-2 pneumonia based on frontal chest X-ray (CXR) images., Methods: Our method used the pretrained LVMs as the primary feature extractor and self-supervised contrastive learning for domain adaptation. An encoder with a 2048-dimensional feature vector output was first trained by self-supervised learning for knowledge domain adaptation. Then a multi-layer perceptron (MLP) was trained for the final severity prediction. A dataset with 2599 CXR images was used for model training and evaluation., Results: The model based on the pretrained vision transformer (ViT) and self-supervised learning achieved the best performance in cross validation, with mean squared error (MSE) of 23.83 (95 % CI 22.67-25.00) and mean absolute error (MAE) of 3.64 (95 % CI 3.54-3.73). Its prediction correlation has the R 2 of 0.81 (95 % CI 0.79-0.82) and Spearman ρ of 0.80 (95 % CI 0.77-0.81), which are comparable to the current state-of-the-art (SOTA) methods trained by much larger CXR datasets., Conclusion: The proposed new method has achieved the SOTA performance to quantify the severity of SARS-CoV-2 pneumonia at a significantly lower cost. The method can be extended to other infectious disease detection or quantification to expedite the application of AI in medical research., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Published by Elsevier Ltd.)

For deep learning-based machine learning, not only are large and sufficiently diverse data crucial but their good qualities are equally important. However, in real-world applications, it is very common that raw source data may contain incorrect, noisy, inconsistent, improperly formatted and sometimes missing elements, particularly, when the datasets are large and sourced from many sites. In this paper, we present our work towards preparing and making image data ready for the development of AI-driven approaches for studying various aspects of the natural history of oral cancer. Specifically, we focus on two aspects: 1) cleaning the image data; and 2) extracting the annotation information. Data cleaning includes removing duplicates, identifying missing data, correcting errors, standardizing data sets, and removing personal sensitive information, toward combining data sourced from different study sites. These steps are often collectively referred to as data harmonization. Annotation information extraction includes identifying crucial or valuable texts that are manually entered by clinical providers related to the image paths/names and standardizing of the texts of labels. Both are important for the successful deep learning algorithm development and data analyses. Specifically, we provide details on the data under consideration, describe the challenges and issues we observed that motivated our work, present specific approaches and methods that we used to clean and standardize the image data and extract labelling information. Further, we discuss the ways to increase efficiency of the process and the lessons learned. Research ideas on automating the process with ML-driven techniques are also presented and discussed. Our intent in reporting and discussing such work in detail is to help provide insights in automating or, minimally, increasing the efficiency of these critical yet often under-reported processes.

Novel screening and diagnostic tests based on artificial intelligence (AI) image recognition algorithms are proliferating. Some initial reports claim outstanding accuracy followed by disappointing lack of confirmation, including our own early work on cervical screening. This is a presentation of lessons learned, organized as a conceptual step-by-step approach to bridge the gap between the creation of an AI algorithm and clinical efficacy. The first fundamental principle is specifying rigorously what the algorithm is designed to identify and what the test is intended to measure (eg, screening, diagnostic, or prognostic). Second, designing the AI algorithm to minimize the most clinically important errors. For example, many equivocal cervical images cannot yet be labeled because the borderline between cases and controls is blurred. To avoid a misclassified case-control dichotomy, we have isolated the equivocal cases and formally included an intermediate, indeterminate class (severity order of classes: case>indeterminate>control). The third principle is evaluating AI algorithms like any other test, using clinical epidemiologic criteria. Repeatability of the algorithm at the borderline, for indeterminate images, has proven extremely informative. Distinguishing between internal and external validation is also essential. Linking the AI algorithm results to clinical risk estimation is the fourth principle. Absolute risk (not relative) is the critical metric for translating a test result into clinical use. Finally, generating risk-based guidelines for clinical use that match local resources and priorities is the last principle in our approach. We are particularly interested in applications to lower-resource settings to address health disparities. We note that similar principles apply to other domains of AI-based image analysis for medical diagnostic testing., (© The Author(s) 2023. Published by Oxford University Press.)