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Your search keyword '"Apostolova, Margarita D."' showing total 4 results
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4 results on '"Apostolova, Margarita D."'

1. A template wizard for the cocreation of machine-readable data-reporting to harmonize the evaluation of (nano)materials

Author

European Commission, Slovenian Research Agency, Norwegian Research Council, Jeliazkova, Nina [0000-0002-4322-6179], Longhin, Eleonora [0000-0002-3939-7135], El Yamani, Naouale [0000-0001-5456-8230], Rundén-Pran, Elise [0000-0002-5541-4513], Moschini, Elisa [0000-0001-9825-6263], Serchi, Tommaso [0000-0003-2386-3514], Vrček, Ivana Vinković [0000-0003-1382-5581], Burgum, Michael J. [0000-0002-3123-8914], Doak, Shareen H. [0000-0002-6753-1987], Cimpan, Mihaela Roxana [0000-0003-2029-3173], Battistelli, Chiara [0000-0003-2386-0727], Bossa, Cecilia [0000-0003-2084-2902], Tsekovska, Rositsa [0000-0001-5431-5743], Drobne, Damjana [0000-0002-5970-7460], Novak, Sara [0000-0003-0026-456X], Repar, Neža [0000-0003-4310-0362], Ammar, Ammar [0000-0002-8399-8990], Nymark, Penny [0000-0002-3435-7775], Di Battista, Veronica [0000-0002-6491-9185], Sosnowska, Anita [0000-0003-3288-4309], Puzyn, Tomasz [0000-0003-0449-8339], Kochev, Nikolay [0000-0001-6547-3675], Iliev, Luchesar [0000-0001-7000-8890], Jeliazkov, Vedrin [0000-0002-1520-5995], Reilly, Katie [0000-0002-6054-0645], Lynch, Iseult [0000-0003-4250-4584], Bakker, Martine [0000-0001-8379-7016], Delpivo, Camila [0000-0002-4413-7602], Sánchez-Jiménez, A. [0000-0002-2625-9155], Fonseca, Ana Sofia [0000-0002-1424-6365], Manier, Nicolas [0000-0003-3873-6657], Fernández-Cruz, M. L. [0000-0001-5988-1939], Rashid, Shahzad [0009-0002-3525-6607], Willighagen, Egon L. [0000-0001-7542-0286], Apostolova, Margarita D. [0000-0001-7188-506X], Dusinska, Maria [0000-0003-1358-1652], Jeliazkova, Nina, Longhin, Eleonora, El Yamani, Naouale, Rundén-Pran, Elise, Moschini, Elisa, Serchi, Tommaso, Vrček, Ivana Vinković, Burgum, Michael J., Doak, Shareen H., Cimpan, Mihaela Roxana, Rios-Mondragon, Ivan, Cimpan, Emil, Battistelli, Chiara, Bossa, Cecilia, Tsekovska, Rositsa, Drobne, Damjana, Novak, Sara, Repar, Neža, Ammar, Ammar, Nymark, Penny, Di Battista, Veronica, Sosnowska, Anita, Puzyn, Tomasz, Kochev, Nikolay, Iliev, Luchesar, Jeliazkov, Vedrin, Reilly, Katie, Lynch, Iseult, Bakker, Martine, Delpivo, Camila, Sánchez-Jiménez, A., Fonseca, Ana Sofia, Manier, Nicolas, Fernández-Cruz, M. L., Rashid, Shahzad, Willighagen, Egon L., Apostolova, Margarita D., Dusinska, Maria, European Commission, Slovenian Research Agency, Norwegian Research Council, Jeliazkova, Nina [0000-0002-4322-6179], Longhin, Eleonora [0000-0002-3939-7135], El Yamani, Naouale [0000-0001-5456-8230], Rundén-Pran, Elise [0000-0002-5541-4513], Moschini, Elisa [0000-0001-9825-6263], Serchi, Tommaso [0000-0003-2386-3514], Vrček, Ivana Vinković [0000-0003-1382-5581], Burgum, Michael J. [0000-0002-3123-8914], Doak, Shareen H. [0000-0002-6753-1987], Cimpan, Mihaela Roxana [0000-0003-2029-3173], Battistelli, Chiara [0000-0003-2386-0727], Bossa, Cecilia [0000-0003-2084-2902], Tsekovska, Rositsa [0000-0001-5431-5743], Drobne, Damjana [0000-0002-5970-7460], Novak, Sara [0000-0003-0026-456X], Repar, Neža [0000-0003-4310-0362], Ammar, Ammar [0000-0002-8399-8990], Nymark, Penny [0000-0002-3435-7775], Di Battista, Veronica [0000-0002-6491-9185], Sosnowska, Anita [0000-0003-3288-4309], Puzyn, Tomasz [0000-0003-0449-8339], Kochev, Nikolay [0000-0001-6547-3675], Iliev, Luchesar [0000-0001-7000-8890], Jeliazkov, Vedrin [0000-0002-1520-5995], Reilly, Katie [0000-0002-6054-0645], Lynch, Iseult [0000-0003-4250-4584], Bakker, Martine [0000-0001-8379-7016], Delpivo, Camila [0000-0002-4413-7602], Sánchez-Jiménez, A. [0000-0002-2625-9155], Fonseca, Ana Sofia [0000-0002-1424-6365], Manier, Nicolas [0000-0003-3873-6657], Fernández-Cruz, M. L. [0000-0001-5988-1939], Rashid, Shahzad [0009-0002-3525-6607], Willighagen, Egon L. [0000-0001-7542-0286], Apostolova, Margarita D. [0000-0001-7188-506X], Dusinska, Maria [0000-0003-1358-1652], Jeliazkova, Nina, Longhin, Eleonora, El Yamani, Naouale, Rundén-Pran, Elise, Moschini, Elisa, Serchi, Tommaso, Vrček, Ivana Vinković, Burgum, Michael J., Doak, Shareen H., Cimpan, Mihaela Roxana, Rios-Mondragon, Ivan, Cimpan, Emil, Battistelli, Chiara, Bossa, Cecilia, Tsekovska, Rositsa, Drobne, Damjana, Novak, Sara, Repar, Neža, Ammar, Ammar, Nymark, Penny, Di Battista, Veronica, Sosnowska, Anita, Puzyn, Tomasz, Kochev, Nikolay, Iliev, Luchesar, Jeliazkov, Vedrin, Reilly, Katie, Lynch, Iseult, Bakker, Martine, Delpivo, Camila, Sánchez-Jiménez, A., Fonseca, Ana Sofia, Manier, Nicolas, Fernández-Cruz, M. L., Rashid, Shahzad, Willighagen, Egon L., Apostolova, Margarita D., and Dusinska, Maria

Abstract

Making research data findable, accessible, interoperable and reusable (FAIR) is typically hampered by a lack of skills in technical aspects of data management by data generators and a lack of resources. We developed a Template Wizard for researchers to easily create templates suitable for consistently capturing data and metadata from their experiments. The templates are easy to use and enable the compilation of machine-readable metadata to accompany data generation and align them to existing community standards and databases, such as eNanoMapper, streamlining the adoption of the FAIR principles. These templates are citable objects and are available as online tools. The Template Wizard is designed to be user friendly and facilitates using and reusing existing templates for new projects or project extensions. The wizard is accompanied by an online template validator, which allows self-evaluation of the template (to ensure mapping to the data schema and machine readability of the captured data) and transformation by an open-source parser into machine-readable formats, compliant with the FAIR principles. The templates are based on extensive collective experience in nanosafety data collection and include over 60 harmonized data entry templates for physicochemical characterization and hazard assessment (cell viability, genotoxicity, environmental organism dose-response tests, omics), as well as exposure and release studies. The templates are generalizable across fields and have already been extended and adapted for microplastics and advanced materials research. The harmonized templates improve the reliability of interlaboratory comparisons, data reuse and meta-analyses and can facilitate the safety evaluation and regulation process for (nano) materials.

Published
2024

2. One-Step Magneton Sputtering of Crystalline Cu-Doped TiO 2 Coatings: Characterization and Antibacterial Activity.

Author

Nikolova, Maria P., Yousefi, Sadegh, Handzhiyski, Yordan, and Apostolova, Margarita D.

Subjects
ESCHERICHIA coli, CONTACT angle, ATMOSPHERIC oxygen, DC sputtering, SUBSTRATES (Materials science)
Abstract

Early biofilm formation could be inhibited by applying a thin biocompatible copper coating to reduce periprosthetic infections. In this study, we deposited crystalline Cu-doped TiO2 films using one-step DC magnetron sputtering in an oxygen atmosphere on a biased Ti6Al4V alloy without external heating. The bias voltage varied from −25 V to −100 V, and the resultant substrate temperature was measured. The deposited coatings were characterized using X-ray diffraction (XRD), scanning electron microscopy (SEM), microhardness, scratch and hydrophilicity tests, potentiodynamic polarization measurements, and antibacterial assays against S. aureus and E. coli. The findings demonstrated that when a higher negative bias is applied, the substrate temperature drops, and the anatase to rutile transformation is initiated without indicating obvious Cu-containing phases. The SEM images of the films showed spherical agglomerates with homogeneously distributed Cu with decreasing Cu content as the bias value increased. Higher bias results in the grain refinement of the thinning coatings with more lattice microstrain and more defects, together with an increase in water contact angles and hardness values. Samples biased at −75 V exhibited the highest adhesive strength between coatings and substrate, whereas the specimen biased at −50 V demonstrated higher corrosion resistance. Cu-containing TiO2 coatings with pure anatase phase composition and Cu concentrations of 2.62 wt.% demonstrated excellent bactericidal activity against both S. aureus and E. coli. The layers containing 2.34 wt.% Cu exhibited very good antibacterial properties against S. aureus, only. According to these findings, the produced copper-doped TiO2 coatings have high bactericidal qualities in vitro and may be used to prepare orthopaedic and dental implants in the future. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Effect of Co-Sputtered Copper and Titanium Oxide Coatings on Bacterial Resistance and Cytocompatibility of Osteoblast Cells.

Author

Nikolova, Maria P., Tzvetkov, Iliyan, Dimitrova, Tanya V., Ivanova, Veronika L., Handzhiyski, Yordan, Andreeva, Andreana, Valkov, Stefan, Ormanova, Maria, and Apostolova, Margarita D.

Subjects
TITANIUM oxides, COPPER-titanium alloys, OXIDE coating, DRUG resistance in bacteria, CONTACT angle, RUTILE
Abstract

One of the primary risk factors for implant failure is thought to be implant-related infections during the early healing phase. Developing coatings with cell stimulatory behaviour and bacterial adhesion control is still difficult for bone implants. This study proposes an approach for one-step deposition of biocompatible and antimicrobial Cu-doped TiO2 coatings via glow-discharge sputtering of a mosaic target. During the deposition, the bias of the Ti6Al4V substrates was changed. Structure examination, phase analysis, and surface morphology were carried out using X-ray diffraction (XRD) analysis, scanning electron microscopy (SEM), atomic force microscopy (AFM), and X-ray photoelectron spectroscopy (XPS). The hardness values and hydrophilic and corrosion performance were also evaluated together with cytocompatible and antibacterial examinations against E. coli and S. aureus. The results show great chemical and phase control of the bias identifying rutile, anatase, CuO, or ternary oxide phases. It was found that by increasing the substrate bias from 0 to −50 V the Cu content increased from 15.3 up to 20.7 at% while at a high bias of −100 V, the copper content reduced to 3 at%. Simultaneously, apart from the Cu2+ state, Cu1+ is also found in the biased samples. Compared with the bare alloy, the hardness, the water contact angle and corrosion resistance of the biased coatings increased. According to an assessment of in vitro cytocompatibility, all coatings were found to be nontoxic to MG-63 osteoblast cells over the time studied. Copper release and cell-surface interactions generated an antibacterial effect against E. coli and S. aureus strains. The −50 V biased coating combined the most successful results in inhibiting bacterial growth and eliciting the proper responses from osteoblastic cells because of its phase composition, electrochemical stability, hydrophilicity, improved substrate adhesion, and surface roughness. Using this novel surface modification approach, we achieved multifunctionality through controlled copper content and oxide phase composition in the sputtered films. [ABSTRACT FROM AUTHOR]

Published
2024
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