8 results on '"Ashley, D."'
Search Results
2. Effects of Ca2+ on the Structure and Dynamics of PIP3 in Model Membranes Containing PC and PS.
- Author
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Bernstein, Ashley D., Asante Ampadu, Gertrude A., Yang, Yanxing, Acharya, Gobin Raj, Osborn Popp, Thomas M., and Nieuwkoop, Andrew J.
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- 2025
- Full Text
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3. A qualitative analysis of innovation forums for community violence prevention: the Big Idea.
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Ortiz, Damaris, Casbon, Courtney, Padgett, Samantha, Overley, Ashley, Magee, Lauren A., Adams, Zachary W., Meagher, Ashley D., Landman, Matthew P., Davis, Tiffany, Belchos, Jessica, Streib, Erik W., and Boustani, Malaz
- Abstract
Background: Communication and collaboration between healthcare, community, and government organizations is key for community violence prevention. This qualitative study aimed to assess Innovation Forum (IF) participant solutions' alignment with recommended strategies, to identify innovative solutions, and to identify the most common participant priorities. Methods: IF were held via teleconference in August 2022 in Indianapolis, Indiana with participants from healthcare organizations, the community, and local government. Forum solutions were documented, coded, and categorized to eight recommended violence prevention strategies from the Centers for Disease Control and Prevention (CDC) and the National Institute for Criminal Justice Reform (NICJR). Uncategorized solutions were considered innovative. Solutions were analyzed by descriptive thematic analysis to identify participant priorities. Results: Seventy-seven participants and 11 facilitators participated in 10 IF. Participants generated 162 solutions. Twenty-two solutions were unable to be categorized according to the CDC and NICJR strategies. The most common participant priorities were: 1. Improve collaboration between existing community organizations and dissemination of resources (42, 21.9%), 2. Improve the community's physical and social environment (27, 14.1%), 3. Increase public awareness and media campaigns (26, 13.5%), 4. Promote a nurturing environment and supports for children and youth (26, 13.5%), and 5. Increase employment, vocational skills, and trade programs (19, 9.9%). Conclusions: Innovation forums identified innovative solutions and participant priorities for violence prevention with representatives from healthcare, the community, and government organizations. Most solutions and priorities aligned with national recommendations, reinforcing their relevance at the community level. [ABSTRACT FROM AUTHOR]
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- 2025
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4. Evaluating a 12-week aerobic exercise intervention in adults with persisting post-concussive symptoms.
- Author
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Mercier, Leah J., McIntosh, Samantha J., Boucher, Chloe, Joyce, Julie M., Batycky, Julia, Galarneau, Jean-Michel, Burma, Joel S., Smirl, Jonathan D., Esser, Michael J., Schneider, Kathryn J., Dukelow, Sean P., Harris, Ashley D., and Debert, Chantel T.
- Abstract
Background: Although guidelines support aerobic exercise in sub-acute mild traumatic brain injury (mTBI), evidence for adults with persisting post-concussive symptoms (PPCS) after mTBI is lacking. The objective was to evaluate the impact of a sub-symptom threshold aerobic exercise intervention on overall symptom burden and quality of life in adults with PPCS. Methods: This prospective cohort study was nested within the ACTBI Trial (Aerobic Exercise for treatment of Chronic symptoms following mild Traumatic Brain Injury). A total of 50 adults with a diagnosis of mTBI, PPCS and exercise intolerance completed a 12-week sub-symptom threshold aerobic exercise intervention either immediately after enrollment (i-AEP group; n = 27) or following 6-weeks of stretching (d-AEP group; n = 23). Data from all participants (n = 50) were included in the combined AEP (c-AEP) group. The primary outcome was symptom burden on the Rivermead Post Concussion Symptoms Questionnaire (RPQ). Secondary outcomes included measures of quality of life and specific post-concussive symptoms (depressive and anxiety symptoms, functional impact of headache, fatigue, sleep, dizziness and exercise tolerance). Heart rate, blood pressure and heart rate variability were also assessed to understand autonomic function response to intervention. Results: Participants were a mean (SD) of 42.6 (10.9) years old (74% female) and 25.1 (14.1) months post-mTBI. Following 12-weeks of intervention participants had a significant improvement in symptom burden on the RPQ (i-AEP: mean change = −9.415, p < 0.001; d-AEP: mean change = −3.478, p = 0.034; c-AEP: mean change = −6.446, p < 0.001). Participants also had significant improvement in quality of life (i-AEP: mean change = 9.879, p < 0.001; d-AEP: mean change = 7.994, p < 0.001, c-AEP: mean change = 8.937, p < 0.001), dizziness (i-AEP: mean change = −11.159, p = 0.001; d-AEP: mean change = −6.516, p = 0.019; c-AEP: −8.837, p < 0.001) and exercise tolerance (i-AEP: mean change = 5.987, p < 0.001; d-AEP: mean change = 3.421, p < 0.001; c-AEP: mean change = 4.703, p < 0.001). Headache (mean change = −5.522, p < 0.001) and depressive symptoms (mean change = −3.032, p = 0.001) improved in the i-AEP group. There was no change in measures of autonomic function. Conclusion: A 12-week aerobic exercise intervention improves overall symptom burden, quality of life and specific symptom domains in adults with PPCS. Clinicians should consider prescription of progressive, individualized, sub-symptom threshold aerobic exercise for adults with PPCS even if presenting with exercise intolerance and months-to-years of symptoms. [ABSTRACT FROM AUTHOR]
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- 2025
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5. The Effects of Clinical Exposure on Examination Performance of Nursing Students.
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Schmuke, Ashley D., Armstrong, Kathleen, McGroarty, Cristina, Fuller, Kelli, Rubbelke, Cynthia, and Bultas, Margaret W.
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CLINICAL supervision ,DATA analysis ,RATING of students ,RETROSPECTIVE studies ,DESCRIPTIVE statistics ,MEDICAL records ,ACQUISITION of data ,ANALYSIS of variance ,STATISTICS ,BACCALAUREATE nursing education ,COLLEGE students ,CLINICAL education ,COMPARATIVE studies ,NURSING students - Abstract
Background: Timing of didactic theoretical content with clinical experiences can be challenging due to limited clinical placements and insufficient experienced faculty. However, appropriate and timely clinical experiences for nursing students are essential for developing knowledge and skills. This project evaluated the effects of the timing of clinical experiences on examination performance. Method: A retrospective review compared students' first examination scores (n = 1,620) with the timing and type of clinical exposure in a traditional baccalaureate nursing program in the Midwest. Results: No significant differences in examination scores and timing of clinical exposures were found in adult medical-surgical courses. However, student examination scores were significantly lower in maternal/neonatal and child-health courses when students did not have a clinical exposure linked to the examination. Conclusion: Faculty should consider the effect of the timing of clinical experiences for specialty courses. Timing of medical-surgical content and clinical experiences may not be as essential. [J Nurs Educ. 2025;64(1):44–47.] [ABSTRACT FROM AUTHOR]
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- 2025
- Full Text
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6. Effects of Ca2+on the Structure and Dynamics of PIP3in Model Membranes Containing PC and PS
- Author
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Bernstein, Ashley D., Asante Ampadu, Gertrude A., Yang, Yanxing, Acharya, Gobin Raj, Osborn Popp, Thomas M., and Nieuwkoop, Andrew J.
- Abstract
Phosphatidylinositol phosphates (PIPs) are a family of seven different eukaryotic membrane lipids that have a large role in cell viability, despite their minor concentration in eukaryotic cellular membranes. PIPs tightly regulate cellular processes, such as cellular growth, metabolism, immunity, and development through direct interactions with partner proteins. Understanding the biophysical properties of PIPs in the complex membrane environment is important to understand how PIPs selectively regulate a partner protein. Here, we investigate the structure and dynamics of PIP3in lipid bilayers that are simplified models of the natural membrane environment. We probe the effects of the anionic lipid phosphatidylserine (PS) and the divalent cation Ca2+by using full-length lipids in well-formed bilayers. We used solution and solid-state NMR on naturally abundant 1H, 31P, and 13C atoms combined with molecular dynamics (MD) simulations to characterize the structure and dynamics of PIPs. 1H and 31P 1D spectra show good resolution at temperatures above the phase transition with isolated peaks in the headgroup, interfacial, and bilayer regions. Site-specific assignment of the chemical shifts of these reporters enables the measurement of the effects of Ca2+and PS at the single atom level. In particular, the resolved 31P signals of the PIP3headgroup allow for extremely well-localized information about PIP3phosphate dynamics, which the MD simulations can further explain. A quantitative assessment of cross-polarization kinetics provides additional dynamics measurements for the PIP3headgroups.
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- 2025
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7. Validation and Application of a Perception of Community Adaptive Capacity to Coastal Hazards Measure.
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Pilgreen, Daniel G., Kyle, Gerard T., and Ross, Ashley D.
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PSYCHOMETRICS , *SELF-evaluation , *PREPAREDNESS , *ACQUISITION of data , *HAZARDS - Abstract
Evaluating adaptive capacities that support the resilience of at-risk communities can be from an objective (top-down) approach or from a subjective (bottom-up) approach. While both approaches are valuable, there remains a need for quantitative subjective measures that complement objective measures by grounding understanding in community members’ perceptions and experiences. To address this need, a 12-item self-report assessment scale of community adaptive capacity to coastal hazards was developed and validated using data collected from two samples of Texas Gulf Coast residents. Findings support the psychometric validity and reliability of the measure and indicate that at-risk coastal communities in Texas can be meaningfully segmented using the measure. The perception of greater adaptive capacity, real, or otherwise, may ameliorate natural hazard concerns and inflate beliefs about preparedness. As such, subjective measures are important companions to objective measures of adaptive capacity and can offer opportunities to identify mismatches between top-down approaches to building adaptive capacity and community perceptions. [ABSTRACT FROM AUTHOR]
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- 2025
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8. Adult perceptions of mental health access barriers facing youth in rural Washington State: A group concept mapping study.
- Author
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Graves JM, Abshire DA, Mackelprang JL, Klein TA, Gonzalez C, Parrott K, Eti DU, Ferris JG, Chacon CM, and Beck AD
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- Humans, Female, Adolescent, Male, Adult, Washington, Perception, Middle Aged, Young Adult, Community-Based Participatory Research, Health Services Accessibility standards, Health Services Accessibility statistics & numerical data, Rural Population statistics & numerical data, Mental Health Services standards
- Abstract
Purpose: To explore adult community members' perspectives concerning barriers to mental health care that confront rural-dwelling youth., Methods: Group concept mapping, a participatory community-engaged research method, was used. Adult community members brainstormed and sorted statements describing barriers rural youth encounter in accessing mental health services. Point and cluster maps were created to visualize conceptual similarities between statements. Statements were rated according to their commonness and importance (1: low commonness/importance, 5: high commonness/importance)., Findings: Thirty-five adults sorted and/or rated 71 barriers facing rural youth in accessing mental health services. Seven conceptual clusters were identified: system-level barriers, knowledge and communication, youth concerns, parent/guardian concerns, parent/guardian barriers, costs and convenience, and school-level barriers. Within youth concerns, community members also identified a subcluster focused on stigma. Common and important statements related to limited after-school programs and community mental health support initiatives., Conclusions: Group concept mapping methodology provides structure for conceptualizing challenges facing rural youth in accessing mental health services. Policies should be informed by rural community concerns and priorities. After-school and support programs may align with mental health needs identified by rural communities., (© 2024 National Rural Health Association.)
- Published
- 2025
- Full Text
- View/download PDF
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