4 results on '"Ba, Luo"'
Search Results
2. Incidence and prognosis of olfactory and gustatory dysfunctions related to SARS‐CoV‐2 Omicron strain infection in China: A national multicenter survey of 35,566 individuals
- Author
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Liu, Meng‐Fan, Ma, Rui‐Xia, Cao, Xian‐Bao, Zhang, Hua, Zhou, Shui‐Hong, Jiang, Wei‐Hong, Jiang, Yan, Sun, Jing‐Wu, Yang, Qin‐Tai, Li, Xue‐Zhong, Sun, Ya‐Nan, Shi, Li, Wang, Min, Song, Xi‐Cheng, Chen, Fu‐Quan, Zhang, Xiao‐Shu, Wei, Hong‐Quan, Yu, Shao‐Qing, Zhu, Dong‐Dong, Ba, Luo, Cao, Zhi‐Wei, Xiao, Xu‐Ping, Wei, Xin, Lin, Zhi‐Hong, Chen, Feng‐Hong, Shan, Chun‐Guang, Wang, Guang‐Ke, Ye, Jing, Qu, Shen‐Hong, Zhao, Chang‐Qing, Wang, Zhen‐Lin, Li, Hua‐Bin, Liu, Feng, Cui, Xiao‐Bo, Ye, Sheng‐Nan, Liu, Zheng, Xu, Yu, Cai, Xiao, Huang, Wei, Zhang, Ru‐Xin, Zhao, Yu‐Lin, Yu, Guo‐Dong, Shi, Guang‐Gang, Lu, Mei‐Ping, Shen, Yang, Zhao, Yu‐Tong, Pei, Jia‐Hong, Xie, Shao‐Bing, Yu, Long‐Gang, Liu, Ye‐Hai, Gu, Shao‐Wei, Yang, Yu‐Cheng, Cheng, Lei, and liu, Jian‐Feng
- Abstract
This cross‐sectional study aimed to determine the epidemiology of olfactory and gustatory dysfunctions related to COVID‐19 in China. This study was conducted by 45 tertiary Grade‐A hospitals in China. Online and offline questionnaire data were obtained from patients infected with COVID‐19 between December 28, 2022, and February 21, 2023. The collected information included basic demographics, medical history, smoking and drinking history, vaccination history, changes in olfactory and gustatory functions before and after infection, and other postinfection symptoms, as well as the duration and improvement status of olfactory and gustatory disorders. Complete questionnaires were obtained from 35,566 subjects. The overall incidence of olfactory and taste dysfunction was 67.75%. Being female or being a cigarette smoker increased the likelihood of developing olfactory and taste dysfunction. Having received four doses of the vaccine or having good oral health or being a alcohol drinker decreased the risk of such dysfunction. Before infection, the average olfactory and taste VAS scores were 8.41 and 8.51, respectively; after infection, they decreased to 3.69 and 4.29 and recovered to 5.83 and 6.55 by the time of the survey. The median duration of dysosmia and dysgeusia was 15 and 12 days, respectively, with 0.5% of patients having symptoms lasting for more than 28 days. The overall self‐reported improvement rate was 59.16%. Recovery was higher in males, never smokers, those who received two or three vaccine doses, and those that had never experienced dental health issues, or chronic accompanying symptoms. The incidence of dysosmia and dysgeusia following infection with the SARS‐CoV‐2 virus is high in China. Incidence and prognosis are influenced by several factors, including sex, SARS‐CoV‐2 vaccination, history of head‐facial trauma, nasal and oral health status, smoking and drinking history, and the persistence of accompanying symptoms.
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- 2024
- Full Text
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3. [Expert consensus on the diagnosis and treatment of respiratory diseases exacerbated by nonsteroidal anti-inflammatory drugs (2024, Chengdu)].
- Author
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Meng J, Ye J, Zhang L, Xu Y, Liu W, Yang Y, Wang X, Jiang Y, Qiu Q, Li J, Yu S, Liu F, Lou H, Wang H, Yu G, Xu R, Meng C, Sun N, Chen J, Zeng M, Xie Z, Sun Y, Tang J, Zhao K, Zhang W, Shi Z, Xu C, Yang Y, Lu M, Ye H, Wei X, Sun B, An Y, Sun Y, Gu Y, Zhang T, Ba L, Yang Q, Xu Y, Yang G, Hong H, Zuo K, and Li H
- Subjects
- Humans, China, Rhinitis diagnosis, Rhinitis therapy, Rhinitis chemically induced, Sinusitis diagnosis, Sinusitis therapy, Sinusitis drug therapy, Consensus, Asthma diagnosis, Asthma drug therapy, Chronic Disease, Anti-Inflammatory Agents, Non-Steroidal adverse effects
- Abstract
Non-steroidal anti-inflammatory drugs-exacerbated respiratory disease (N-ERD) is a chronic respiratory disease characterized by eosinophilic inflammation, featuring chronic rhinosinusitis (CRS), asthma, and intolerance to cyclooxygenase 1 (COX-1) inhibitors. The use of these medications can lead to an acute worsening of rhinitis and asthma symptoms. This condition has not yet received sufficient attention in China, with a high rate of misdiagnosis and a lack of related research. The Chinese Rhinology Research Group convened a group of leading young experts in otolaryngology from across the country, based on the latest domestic and international evidence-based medical practices to formulate this consensus.The consensus covers the epidemiology, pathogenesis, clinical manifestations, diagnostic methods, and treatment strategies for N-ERD, including pharmacotherapy, surgery, biologic treatments, and desensitization therapy. The goal is to improve recognition of N-ERD, reduce misdiagnosis, and enhance treatment outcomes., Competing Interests: The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose., (Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.)
- Published
- 2024
- Full Text
- View/download PDF
4. The oxidant-antioxidant imbalance was involved in the pathogenesis of chronic rhinosinusitis with nasal polyps.
- Author
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Zhou J, Zhou J, Liu R, Liu Y, Meng J, Wen Q, Luo Y, Liu S, Li H, Ba L, and Du J
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- Humans, Chronic Disease, Female, Male, Adult, Middle Aged, Oxidants metabolism, Macrophages metabolism, Macrophages immunology, Cytokines metabolism, Nasal Mucosa metabolism, Nasal Mucosa immunology, Cells, Cultured, Rhinosinusitis, Nasal Polyps metabolism, Nasal Polyps immunology, Sinusitis metabolism, Sinusitis immunology, Rhinitis metabolism, Rhinitis immunology, Antioxidants metabolism, Oxidative Stress
- Abstract
Background: Although oxidative stress is involved in the pathophysiological process of chronic rhinosinusitis with nasal polyps (CRSwNP), the specific underlying mechanism is still unclear. Whether antioxidant therapy can treat CRSwNP needs further investigation., Methods: Immunohistochemistry, immunofluorescence, western blotting and quantitative polymerase chain reaction (qPCR) analyses were performed to detect the distribution and expression of oxidants and antioxidants in nasal polyp tissues. qPCR revealed correlations between oxidase, antioxidant enzymes and inflammatory cytokine levels in CRSwNP patients. Human nasal epithelial cells (HNEpCs) and primary macrophages were cultured to track the cellular origin of oxidative stress in nasal polyps(NPs) and to determine whether crocin can reduce cellular inflammation by increasing the cellular antioxidant capacity., Results: The expression of NOS2, NOX1, HO-1 and SOD2 was increased in nasal epithelial cells and macrophages derived from nasal polyp tissue. Oxidase levels were positively correlated with those of inflammatory cytokines (IL-5 and IL-6). Conversely, the levels of antioxidant enzymes were negatively correlated with those of IL-13 and IFN-γ. Crocin inhibited M1 and M2 macrophage polarization as well as the expression of NOS2 and NOX1 and improved the antioxidant capacity of M2 macrophages. Moreover, crocin enhanced the ability of antioxidants to reduce inflammation via the KEAP1/NRF2/HO-1 pathway in HNEpCs treated with SEB or LPS. Additionally, we observed the antioxidant and anti-inflammatory effects of crocin in nasal explants., Conclusion: Oxidative stress plays an important role in the development of CRSwNP by promoting various types of inflammation. The oxidative stress of nasal polyps comes from epithelial cells and macrophages. Antioxidant therapy may be a promising strategy for treating CRSwNP., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Zhou, Zhou, Liu, Liu, Meng, Wen, Luo, Liu, Li, Ba and Du.)
- Published
- 2024
- Full Text
- View/download PDF
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