7 results on '"Blomqvist, Carl"'
Search Results
2. Association of clinicopathologic variables and patient preference with the choice of surgical treatment for early-stage breast cancer: A registry-based study
- Author
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Söderberg, Emma, Wärnberg, Fredrik, Wennstig, Anna-Karin, Nilsson, Greger, Garmo, Hans, Holmberg, Lars, Blomqvist, Carl, Sund, Malin, and Wadsten, Charlotta
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- 2024
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3. Ultra-low-dose computed tomography and chest X-ray in follow-up of high-grade soft tissue sarcoma—a prospective comparative study
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Salminen, Samuli, primary, Jäämaa, Sari, additional, Nevala, Riikka, additional, Sormaala, Markus J., additional, Koivikko, Mika, additional, Tukiainen, Erkki, additional, Repo, Jussi, additional, Blomqvist, Carl, additional, and Sampo, Mika, additional
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- 2024
- Full Text
- View/download PDF
4. Validation of primary and outcome data quality in a Swedish population-based breast cancer quality registry
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Palmer, Sofia, Blomqvist, Carl, Holmqvist, Marit, Lindman, Henrik, Lambe, Mats, Ahlgren, Johan, Palmer, Sofia, Blomqvist, Carl, Holmqvist, Marit, Lindman, Henrik, Lambe, Mats, and Ahlgren, Johan
- Abstract
Background: Population-based cancer quality registries are of great importance for the improvement of cancer care. However, little is known about the quality of recurrence data in cancer quality registries. The aim of this study was to evaluate data quality in the regional Breast Cancer Quality Registry of Central Sweden, with emphasis on the validity of recorded information on recurrence. Methods: Validation by re-abstraction was performed on a random sample of 800 women with primary invasive breast cancer stage I-III diagnosed between 1993 and 2010, of which 400 had at least one registered recurrence and 400 had no registered recurrence. Registry data were compared with data from medical records. Exact agreement, correlation and kappa values, sensitivity and specificity were calculated. Results: Seven hundred forty-seven women (93%) were available for analysis. Exact agreement was high for diagnostics, tumor characteristics, surgery, and adjuvant oncological treatment (90% or more for most variables). The registry's sensitivity was low for regional recurrence (47%), but higher for local and distant recurrence (80% and 75%), whereas specificity was overall high (>= 95%). Combining all recurrence categories irrespective of localization improved sensitivity to 90% with a specificity of 91%. In 87% of women, the date of first recurrence according to medical records fell within +/- 90 days of the date recorded in the registry. Conclusions: While the quality of data in the regional Breast Cancer Quality Registry was generally high, data accuracy on recurrences was lower. The overall precision of identifying any recurrence, irrespective of localization, was high. However, the accuracy of classification of recurrences (local, regional or distant) was lower, with evidence of underreporting for each of the recurrence categories. Given the importance of recurrence-related outcomes in the assessment of quality of care, efforts should be made to improve the reporting of rec
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- 2024
- Full Text
- View/download PDF
5. Etablering av ett nytt stomnät i plan och höjd i SWEREF 99 16 30 och RH 2000 i Hus 45 vid Högskolan i Gävle
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Blomqvist, Carl, Forsmark, Johan, Blomqvist, Carl, and Forsmark, Johan
- Abstract
Stommätning innebär att etablera, komplettera och/eller renovera stompunkter i ett stomnät. Syftet med examensarbetet är att etablera ett stomnät i plan i referenssystemet SWEREF 99 16 30 och i höjd i RH 2000 inomhus i Hus 45, Heimdall, vid Högskolan i Gävle. Det undersöks särskilt vilken relativ lägesosäkerhet som är möjlig att uppnå med avseende på de praktiska begränsningar som finns i Hus 45 med begränsad sikt mellan punkterna. Önskemålet gällande nätets relativa standardosäkerheter är 2–3 mm i plan och 1–2 mm i höjd och för att uppnå det undersöks hur nätet i plan och höjd bör planeras, markeras, mätas och beräknas. Metoden för projektet följer i stora drag rekommendationerna i HMK när det gäller stommätning, beräkning och utvärdering. Först har nätets preliminära utformning rekognoserats, vilket sedan har legat till grund för simuleringar. Dessa gjordes för att få en uppfattning om vilken kvalitet en viss nätutformning skulle ge och på så sätt kunde en så bra geometri som möjligt väljas. Tre olika planeringsförslag togs fram i både plan och höjd. Mätningarna har utförts med en totalstation, Trimble S51” och ett digitalt avvägningsinstrument, Trimble DiNi. Genom helsatsmätning och dubbelmätta längder med 45 fria stationsuppställningar i plan, och finavvägning med hjälp av 28 dubbelavvägda fixhåll som kompletterats med trigonometrisk höjdmätning, har punkterna i plan och höjd mätts in. Beräkning av koordinater och kvalitetsparametrar för nypunkterna har utförts i en nätutjämning i plan och en i höjd i programvaran SBG Geo. I plan exkluderades 34 observationer (data-snooping) från en fri utjämning, som slutligen passades in mot de kända punkterna med en plan Helmerttransformation. Kvalitetsparametrarna för nätet i plan inkluderar utvärdering av viktenhetens standardosäkerhet (0,64), kontroll av det genomsnittliga k-talet (0,58) samt kontroll enligt HMK:s 3-nivåprincip (2 observationer utanför kassationsgränsen). I höjd togs 9 observationer bort med data-snoopi, Control point surveying involves establishing, supplementing, and/or renovating control points in a control network. The purpose of the thesis is to establish a control network in the horizontal in the SWEREF 99 16 30 reference system and in height in the RH 2000 height system. The network is situated indoors in Building 45, Heimdall, at the University of Gävle. The thesis specifically examines the achievable relative standard uncertainty considering the practical limitations in Building 45 with limited visibility between points. The required relative standard uncertainties for the network are 2-3 mm in the horizontal and 1-2 mm in the height component. To achieve this goal, different ways to plan, mark, measure, and calculate the network are studied. The project methodology broadly follows the recommendations in the Swedish HMK handbook for control point surveying, calculation, and evaluation. First, reconnaissance was made of the preliminary network design, which then formed the basis for simulations. These were made to assess the quality of a particular network design, allowing for the selection of the best possible geometry. Three different planning proposals were developed both in the horizontal and in the vertical. Measurements were carried out using a total station, Trimble S51”, and a digital levelling instrument, Trimble DiNi. By conducting full set measurements and double-measured distances from 45 free stations, and double run levelling of 28 height differences complemented by trigonometric heighting, the horizontal and vertical coordinates of the points were determined. The adjustment and estimation of quality parameters were performed using the network adjustment module in SBG Geo. 34 observations were excluded by data-snooping from an unconstrained adjustment, which was subsequently fitted to the known stations using a Helmert transformation. Quality parameters for the network in the horizontal include evaluation of the standard uncertainty of unit wei
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- 2024
6. A Retrospective Analysis of Systemic Oncologic Treatment in Older Patients With Advanced Soft-tissue Sarcoma.
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Lemma J, Liljeström J, Sampo M, Nevala R, Blomqvist C, Elmegiri M, and Jäämaa S
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- Humans, Retrospective Studies, Aged, Male, Female, Middle Aged, Aged, 80 and over, Age Factors, Treatment Outcome, Sarcoma drug therapy, Sarcoma pathology, Sarcoma mortality
- Abstract
Background/aim: Almost half of all patients with soft-tissue sarcoma are over 65 years of age, and the proportion of older patients is increasing. Despite this, they have been underrepresented in clinical trials and only limited data are available to guide treatment decisions. The aim of this study was to investigate treatment patterns and outcomes in older patients with soft-tissue sarcoma., Patients and Methods: Patients over 50 years old treated for advanced soft-tissue sarcoma at the Helsinki University Hospital between January 2000 and July 2020 were included. Data on patient and tumor characteristics, treatment, and survival were retrospectively collected. A total of 152 patients were included: 14.5% (n=22) were over 75 years old, 34.2% (n=52) were 65-74 and 51.3% (n=78) were 50-64 years old., Results: The outcomes of the oldest group differed from those of younger patients; they were more likely to receive single-agent treatment as first-line therapy (90.9% vs. 28.8% and 24.4%, p<0.001) and had the lowest relative dose-intensity (70% vs. 88% and 95%, p<0.05). They experienced grade three to four hematological adverse events less frequently (38.1%, 56.9% and 72.7%, respectively, p=0.031), and received fewer lines of treatment (median of 1, 2 and 2, respectively, p=0.01). In patients aged ≥75 years, there was no association between further lines of therapy and improved survival. Compared to the youngest group, the oldest patients had a greater risk of dying (hazard ratio=1.7, 95% confidence interval=1.0-2.8, p=0.041) and their median overall survival was only 7.4 months, compared to 14.3 and 12.9 months in the two younger groups., Conclusion: These findings suggest that older patients tolerate chemotherapy when treatment is tailored to their needs but may not benefit as much as younger patients., (Copyright © 2024 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
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- 2024
- Full Text
- View/download PDF
7. Validation of primary and outcome data quality in a Swedish population-based breast cancer quality registry.
- Author
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Palmér S, Blomqvist C, Holmqvist M, Lindman H, Lambe M, and Ahlgren J
- Subjects
- Humans, Female, Data Accuracy, Sweden epidemiology, Sensitivity and Specificity, Registries, Neoplasm Recurrence, Local epidemiology, Neoplasm Recurrence, Local pathology, Breast Neoplasms diagnosis, Breast Neoplasms epidemiology, Breast Neoplasms therapy
- Abstract
Background: Population-based cancer quality registries are of great importance for the improvement of cancer care. However, little is known about the quality of recurrence data in cancer quality registries. The aim of this study was to evaluate data quality in the regional Breast Cancer Quality Registry of Central Sweden, with emphasis on the validity of recorded information on recurrence., Methods: Validation by re-abstraction was performed on a random sample of 800 women with primary invasive breast cancer stage I-III diagnosed between 1993 and 2010, of which 400 had at least one registered recurrence and 400 had no registered recurrence. Registry data were compared with data from medical records. Exact agreement, correlation and kappa values, sensitivity and specificity were calculated., Results: Seven hundred forty-seven women (93%) were available for analysis. Exact agreement was high for diagnostics, tumor characteristics, surgery, and adjuvant oncological treatment (90% or more for most variables). The registry's sensitivity was low for regional recurrence (47%), but higher for local and distant recurrence (80% and 75%), whereas specificity was overall high (≥ 95%). Combining all recurrence categories irrespective of localization improved sensitivity to 90% with a specificity of 91%. In 87% of women, the date of first recurrence according to medical records fell within ± 90 days of the date recorded in the registry., Conclusions: While the quality of data in the regional Breast Cancer Quality Registry was generally high, data accuracy on recurrences was lower. The overall precision of identifying any recurrence, irrespective of localization, was high. However, the accuracy of classification of recurrences (local, regional or distant) was lower, with evidence of underreporting for each of the recurrence categories. Given the importance of recurrence-related outcomes in the assessment of quality of care, efforts should be made to improve the reporting of recurrences., (© 2024. The Author(s).)
- Published
- 2024
- Full Text
- View/download PDF
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