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Your search keyword '"Borchmann, Sven"' showing total 7 results
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7 results on '"Borchmann, Sven"'

1. Assessing the efficacy and tolerability of PET-guided BrECADD versus eBEACOPP in advanced-stage, classical Hodgkin lymphoma (HD21): a randomised, multicentre, parallel, open-label, phase 3 trial

Author

Borchmann, Peter, Ferdinandus, Justin, Schneider, Gundolf, Moccia, Alden, Greil, Richard, Hertzberg, Mark, Schaub, Valdete, Hüttmann, Andreas, Keil, Felix, Dierlamm, Judith, Hänel, Mathias, Novak, Urban, Meissner, Julia, Zimmermann, Andreas, Mathas, Stephan, Zijlstra, Josée M, Fosså, Alexander, Viardot, Andreas, Hertenstein, Bernd, Martin, Sonja, Giri, Pratyush, Scholl, Sebastian, Topp, Max S, Jung, Wolfram, Vucinic, Vladan, Beck, Hans-Joachim, Kerkhoff, Andrea, Unger, Benjamin, Rank, Andreas, Schroers, Roland, zum Büschenfelde, Christian Meyer, de Wit, Maike, Trautmann-Grill, Karolin, Kamper, Peter, Molin, Daniel, Kreissl, Stefanie, Kaul, Helen, von Tresckow, Bastian, Borchmann, Sven, Behringer, Karolin, Fuchs, Michael, Rosenwald, Andreas, Klapper, Wolfram, Eich, Hans-Theodor, Baues, Christian, Zomas, Athanasios, Hallek, Michael, Dietlein, Markus, Kobe, Carsten, and Diehl, Volker

Published
2024
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2. Entirely noninvasive outcome prediction in central nervous system lymphomas using circulating tumor DNA

Author

Heger, Jan-Michel, Mattlener, Julia, Schneider, Jessica, Gödel, Philipp, Sieg, Noëlle, Ullrich, Fabian, Lewis, Richard, Bucaciuc-Mracica, Teodora, Schwarz, Roland F., Rueß, Daniel, Ruge, Maximilian I., Montesinos-Rongen, Manuel, Deckert, Martina, Blau, Tobias, Kutsch, Nadine, Balke-Want, Hyatt, Weiss, Jonathan, Becker, Kerstin, Reinhardt, H. Christian, Hallek, Michael, Borchmann, Peter, von Tresckow, Bastian, and Borchmann, Sven

Published
2024
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3. Procarbazine-induced Genomic Toxicity in Hodgkin Lymphoma Survivors

Author

Santarsieri, Anna, primary, Mitchell, Emily, additional, Pham, My H., additional, Sanghvi, Rashesh, additional, Jablonski, Janina, additional, Lee-Six, Henry, additional, Sturgess, Katherine, additional, Brice, Pauline, additional, Menne, Tobias F., additional, Osborne, Wendy, additional, Creasey, Thomas, additional, Ardeshna, Kirit M., additional, Baxter, Joanna, additional, Behan, Sarah, additional, Bhuller, Kaljit, additional, Booth, Stephen, additional, Chavda, Nikesh D., additional, Collins, Graham P., additional, Culligan, Dominic J., additional, Cwynarski, Kate, additional, Davies, Andrew, additional, Downing, Abigail, additional, Dutton, David, additional, Furtado, Michelle, additional, Gallop-Evans, Eve, additional, Hodson, Andrew, additional, Hopkins, David, additional, Hsu, Hannah, additional, Iyengar, Sunil, additional, Jones, Stephen G., additional, Karanth, Mamatha, additional, Linton, Kim M., additional, Lomas, Oliver C., additional, Martinez-Calle, Nicolas, additional, Mathur, Abhinav, additional, McKay, Pamela, additional, Nagumantry, Sateesh K., additional, Phillips, Elizabeth H., additional, Phillips, Neil, additional, Rudge, John F., additional, Shah, Nimish K., additional, Stafford, Gwyneth, additional, Sternberg, Alex, additional, Trickey, Rachel, additional, Uttenthal, Benjamin J., additional, Wetherall, Natasha, additional, Zhang, Xiao-Yin, additional, McMillan, Andrew K., additional, Coleman, Nicholas, additional, Stratton, Michael R., additional, Laurenti, Elisa, additional, Borchmann, Peter, additional, Borchmann, Sven, additional, Campbell, Peter J., additional, Rahbari, Raheleh, additional, and Follows, George A., additional

Published
2024
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4. Plasma Circulating Tumor DNA Sequencing Reveals the Landscape of Acquired Mutations in Patients with Hepatocellular Carcinoma: a Potential Predictive Value in Liquid Biopsy

Author

Wu, Xiaolin, primary, Borchmann, Sven, additional, Heger, Jan-Michel, additional, Kasper, Philipp, additional, Li, Jiahui, additional, Bamberger, Margaux, additional, Gassa, Asmae, additional, Alakus, Hakan, additional, Odenthal, Margarete, additional, Drebber, Uta, additional, Altmüller, Janine, additional, Becker, Kerstin, additional, Stippel, Dirk, additional, Bruns, Christiane J, additional, Zhao, Yue, additional, and Wahba, Roger, additional

Published
2024
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5. Noninvasive minimal residual disease assessment in relapsed/refractory large B‐cell lymphoma using digital droplet PCR

Author

Heger, Jan‐Michel, primary, d'Hargues, Yannick, additional, Kleinert, Fanni, additional, Mattlener, Julia, additional, Weiss, Jonathan, additional, Franzen, Fabian, additional, Becker, Christian, additional, Becker, Kerstin, additional, Gödel, Philipp, additional, Schmiel, Marcel, additional, Meinel, Jörn, additional, Flümann, Ruth, additional, Simon, Florian, additional, Reinhardt, H. Christian, additional, Borchmann, Peter, additional, Borchmann, Sven, additional, Balke‐Want, Hyatt, additional, Knittel, Gero, additional, and von Tresckow, Bastian, additional

Published
2024
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6. Human leukocyte antigen (HLA) class I expression on Hodgkin–Reed–Sternberg cells is an EBV‐independent major determinant of microenvironment composition in classic Hodgkin lymphoma.

Author

Müller‐Meinhard, Berit, Seifert, Nicole, Grund, Johanna, Reinke, Sarah, Yalcin, Fatih, Kaul, Helen, Borchmann, Sven, von Tresckow, Bastian, Borchmann, Peter, Plütschow, Annette, Richter, Julia, Engert, Andreas, Altenbuchinger, Michael, Bröckelmann, Paul J., and Klapper, Wolfram

Published
2024
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7. Blocking the angiopoietin-2-dependent integrin β-1 signaling axis abrogates small cell lung cancer invasion and metastasis.

Author

Meder L, Orschel CI, Otto CJ, Koker M, Brägelmann J, Ercanoglu MS, Dähling S, Compes A, Selenz C, Nill M, Dietlein F, Florin A, Eich ML, Borchmann S, Odenthal M, Blazquez R, Hilberg F, Klein F, Hallek M, Büttner R, Reinhardt HC, and Ullrich RT

Subjects
Animals, Female, Humans, Male, Mice, Cell Line, Tumor, Neoplasm Invasiveness, Neoplasm Metastasis, Angiopoietin-2 metabolism, Angiopoietin-2 genetics, Integrin beta1 metabolism, Integrin beta1 genetics, Liver Neoplasms secondary, Liver Neoplasms metabolism, Liver Neoplasms pathology, Liver Neoplasms genetics, Liver Neoplasms drug therapy, Lung Neoplasms secondary, Lung Neoplasms pathology, Lung Neoplasms metabolism, Lung Neoplasms genetics, Lung Neoplasms drug therapy, Signal Transduction, Small Cell Lung Carcinoma pathology, Small Cell Lung Carcinoma metabolism, Small Cell Lung Carcinoma genetics, Small Cell Lung Carcinoma drug therapy
Abstract

Small cell lung cancer (SCLC) is the most aggressive lung cancer entity with an extremely limited therapeutic outcome. Most patients are diagnosed at an extensive stage. However, the molecular mechanisms driving SCLC invasion and metastasis remain largely elusive. We used an autochthonous SCLC mouse model and matched samples from patients with primary and metastatic SCLC to investigate the molecular characteristics of tumor metastasis. We demonstrate that tumor cell invasion and liver metastasis in SCLC are triggered by an Angiopoietin-2 (ANG-2)/Integrin β-1-dependent pathway in tumor cells, mediated by focal adhesion kinase/Src kinase signaling. Strikingly, CRISPR-Cas9 KO of Integrin β-1 or blocking Integrin β-1 signaling by an anti-ANG-2 treatment abrogates liver metastasis formation in vivo. Interestingly, analysis of a unique collection of matched samples from patients with primary and metastatic SCLC confirmed a strong increase of Integrin β-1 in liver metastasis in comparison with the primary tumor. We further show that ANG-2 blockade combined with PD-1-targeted by anti-PD-1 treatment displays synergistic treatment effects in SCLC. Together, our data demonstrate a fundamental role of ANG-2/Integrin β-1 signaling in SCLC cells for tumor cell invasion and liver metastasis and provide a potentially new effective treatment strategy for patients with SCLC.

Published
2024
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