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Given the increased frequency and destructive nature of seismic events, the exigencies for enhanced management protocols for urban edifices in the milieu of seismic disaster scenarios have intensified. The role of Building Information Modeling (BIM) and Geographic Information Systems (GIS) in the governance of seismic-induced disasters is integral and merits recognition. The synergistic application of BIM and GIS technologies empowers the strategic articulation of measures that substantially abate the potential hazards associated with seismic events. The present manuscript conducts a comprehensive review of the applications of BIM-GIS synergy in the domains of seismic disaster prevention, emergency response, and in the evaluative and recovery phases following such calamities. It also examines the associated data paradigms and advancements in data interoperability techniques while addressing the prevailing limitations within the scope of contemporary research. This study endeavors to enhance the acumen of urban disaster management operatives in discerning and capitalizing on the collective strengths of BIM and GIS, with the aim of optimizing urban strategies for managing seismic disasters and diminishing the resultant losses sustained by the populace.

Given the increased frequency and destructive nature of seismic events, the exigencies for enhanced management protocols for urban edifices in the milieu of seismic disaster scenarios have intensified. The role of Building Information Modeling (BIM) and Geographic Information Systems (GIS) in the governance of seismic-induced disasters is integral and merits recognition. The synergistic application of BIM and GIS technologies empowers the strategic articulation of measures that substantially abate the potential hazards associated with seismic events. The present manuscript conducts a comprehensive review of the applications of BIM-GIS synergy in the domains of seismic disaster prevention, emergency response, and in the evaluative and recovery phases following such calamities. It also examines the associated data paradigms and advancements in data interoperability techniques while addressing the prevailing limitations within the scope of contemporary research. This study endeavors to enhance the acumen of urban disaster management operatives in discerning and capitalizing on the collective strengths of BIM and GIS, with the aim of optimizing urban strategies for managing seismic disasters and diminishing the resultant losses sustained by the populace.

Pancreatic cancer (PCa) is one of the most fatal human malignancies. The enhanced infiltration of stromal tissue into the PCa tumor microenvironment limits the identification of key tumor‐specific transcription factors and epigenomic abnormalities in malignant epithelial cells. Integrated transcriptome and epigenetic multiomics analyses of the paired PCa organoids indicate that the basic helix‐loop‐helix transcription factor 40 (BHLHE40) is significantly upregulated in tumor samples. Increased chromatin accessibility at the promoter region and enhanced mTOR pathway activity contribute to the elevated expression of BHLHE40. Integrated analysis of chromatin immunoprecipitation‐seq, RNA‐seq, and high‐throughput chromosome conformation capture data, together with chromosome conformation capture assays, indicate that BHLHE40 not only regulates sterol regulatory element‐binding factor 1 (SREBF1) transcription as a classic transcription factor but also links the enhancer and promoter regions of SREBF1. It is found that the BHLHE40‐SREBF1‐stearoyl‐CoA desaturase axis protects PCa cells from ferroptosis, resulting in the reduced accumulation of lipid peroxidation. Moreover, fatostatin, an SREBF1 inhibitor, significantly suppresses the growth of PCa tumors with high expressions of BHLHE40. This study highlights the important roles of BHLHE40‐mediated lipid peroxidation in inducing ferroptosis in PCa cells and provides a novel mechanism underlying SREBF1 overexpression in PCa. [ABSTRACT FROM AUTHOR]