10 results on '"Casale, T"'
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2. PHARMACOKINETICS AND PHARMACODYNAMICS FOLLOWING REPEAT DOSING OF EPINEPHRINE NASAL SPRAY VERSUS INTRAMUSCULAR INJECTION DURING ALLERGIC RHINITIS
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Oppenheimer, J., Casale, T., Spergel, J., Bernstein, D., Camargo, C., Ellis, A., Lowenthal, R., and Tanimoto, S.
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- 2024
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3. SIGNIFICANT DIFFERENCES IN PHARMACOKINETIC PROFILES AMONG EPINEPHRINE PRODUCTS-WHAT IS THE MECHANISM FOR EFFICACY?
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Greenhawt, M., Lieberman, J., Casale, T., Nowak-Wegrzyn, A., Spergel, J., Lowenthal, R., and Tanimoto, S.
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- 2024
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4. BLOOD PRESSURE AND PULSE RATE INCREASES, WITHOUT CONCOMITANT EPINEPHRINE INCREASES, DURING ACUTE ALLERGIC REACTIONS
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Spergel, J., Ebisawa, M., Ellis, A., Casale, T., Oppenheimer, J., Camargo, C., Anagnostou, A., Lowenthal, R., and Tanimoto, S.
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- 2024
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5. CARDIOVASCULAR SAFETY OF INTRAMUSCULAR AND INTRANASAL EPINEPHRINE ADMINISTRATION
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Lieberman, J., Wainford, R., Camargo, C., Casale, T., Lowenthal, R., and Tanimoto, S.
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- 2024
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6. Dupilumab significantly improves itch and hives in patients with chronic spontaneous urticaria (CUPID study C).
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Casale, T., Saini, S., Bernstein, J., -Arnau, A. Giménez, Bauer, D., Amin, N., Robinson, L., Dakin, P., Laws, E., Radin, A., and Makhija, M.
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- 2024
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7. WITHDRAWN: Scaling up strategies of the Chronic Respiratory Disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3 – Area 5)
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Bousquet, J., Farrell, J., Crooks, G., Hellings, P., Bel, E.H., Bewick, M., Chavannes, N.H., Correia de Sousa, J., Cruz, A.A., Haahtela, T., Joos, G., Khaltaev, N., Malva, J., Muraro, A., Nogues, M., Palkonen, S., Pedersen, S., Robalo-Cordeiro, C., Samolinski, B., Strandberg, T., Valiulis, A., Yorgancioglu, A., Zuberbier, T., Bedbrook, A., Aberer, W., Adachi, M., Agusti, A., Akdis, C.A., Akdis, M., Ankri, J., Alonso, A., Annesi-Maesano, I., Ansotegui, I.J., Anto, J.M., Arnavielhe, S., Arshad, H., Bai, C., Baiardini, I., Bachert, C., Baigenzhin, A.K., Barbara, C., Bateman, E.D., Beghé, B., Ben Kheder, A., Bennoor, K.S., Benson, M., Bergmann, K.C., Bieber, T., Bindslev-Jensen, C., Bjermer, L., Blain, H., Blasi, F., Boner, A.L., Bonini, M., Bonini, S., Bosnic-Anticevitch, S., Boulet, L.P., Bourret, R., Bousquet, P.J., Braido, F., Briggs, A.H., Brightling, C.E., Brozek, J., Buhl, R., Burney, P.G., Bush, A., Caballero-Fonseca, F., Caimmi, D., Calderon, M.A., Calverley, P.M., Camargos, P.A.M., Canonica, G.W., Camuzat, T., Carlsen, K.H., Carr, W., Carriazo, A., Casale, T., Cepeda Sarabia, A.M., Chatzi, L., Chen, Y.Z., Chiron, R., Chkhartishvili, E., Chuchalin, A.G., Chung, K.F., Ciprandi, G., Cirule, I., Cox, L., Costa, D.J., Custovic, A., Dahl, R., Dahlen, S.E., Darsow, U., De Carlo, G., De Blay, F., Dedeu, T., Deleanu, D., De Manuel Keenoy, E., Demoly, P., Denburg, J.A., Devillier, P., Didier, A., Dinh-Xuan, A.T., Djukanovic, R., Dokic, D., Douagui, H., Dray, G., Dubakiene, R., Durham, S.R., Dykewicz, M.S., El-Gamal, Y., Emuzyte, R., Fabbri, L.M., Fletcher, M., Fiocchi, A., Fink Wagner, A., Fonseca, J., Fokkens, W.J., Forastiere, F., Frith, P., Gaga, M., Gamkrelidze, A., Garces, J., Garcia-Aymerich, J., Gemicioğlu, B., Gereda, J.E., González Diaz, S., Gotua, M., Grisle, I., Grouse, L., Gutter, Z., Guzmán, M.A., Heaney, L.G., Hellquist-Dahl, B., Henderson, D., Hendry, A., Heinrich, J., Heve, D., Horak, F., Hourihane, J.O’B., Howarth, P., Humbert, M., Hyland, M.E., Illario, M., Ivancevich, J.C., Jardim, J.R., Jares, E.J., Jeandel, C., Jenkins, C., Johnston, S.L., Jonquet, O., Julge, K., Jung, K.S., Just, J., Kaidashev, I., Kaitov, M.R., Kalayci, O., Kalyoncu, A.F., Keil, T., Keith, P.K., Klimek, L., Koffi N’Goran, B., Kolek, V., Koppelman, G.H., Kowalski, M.L., Kull, I., Kuna, P., Kvedariene, V., Lambrecht, B., Lau, S., Larenas-Linnemann, D., Laune, D., Le, L.T.T., Lieberman, P., Lipworth, B., Li, J., Lodrup Carlsen, K., Louis, R., MacNee, W., Magard, Y., Magnan, A., Mahboub, B., Mair, A., Majer, I., Makela, M.J., Manning, P., Mara, S., Marshall, G.D., Masjedi, M.R., Matignon, P., Maurer, M., Mavale-Manuel, S., Melén, E., Melo-Gomes, E., Meltzer, E.O., Menzies-Gow, A., Merk, H., Michel, J.P., Miculinic, N., Mihaltan, F., Milenkovic, B., Moda Y. Mohammad, G., Molimard, M., Momas, I., Montilla-Santana, A., Morais-Almeida, M., Morgan, M., Mösges, R., Mullol, J., Nafti, S., Namazova-Baranova, L., Naclerio, R., Neou, A., Neffen, H., Nekam, K., Niggemann, B., Ninot, G., Nyembue, T.D., O’Hehir, R.E., Ohta, K., Okamoto, Y., Okubo, K., Ouedraogo, S., Paggiaro, P., Pali-Schöll, I., Panzner, P., Papadopoulos, N., Papi, A., Park, H.S., Passalacqua, G., Pavord, I., Pawankar, R., Pengelly, R., Pfaar, O., Picard, R., Pigearias, B., Pin, I., Plavec, D., Poethig, D., Pohl, W., Popov, T.A., Portejoie, F., Potter, P., Postma, D., Price, D., Rabe, K.F., Raciborski, F., Radier Pontal, F., Repka-Ramirez, S., Reitamo, S., Rennard, S., Rodenas, F., Roberts, J., Roca, J., Rodriguez Mañas, L., Rolland, C., Roman Rodriguez, M., Romano, A., Rosado-Pinto, J., Rosario, N., Rosenwasser, L., Rottem, M., Ryan, D., Sanchez-Borges, M., Scadding, G.K., Schunemann, H.J., Serrano, E., Schmid-Grendelmeier, P., Schulz, H., Sheikh, A., Shields, M., Siafakas, N., Sibille, Y., Similowski, T., Simons, F.E.R., Sisul, J.C., Skrindo, I., Smit, H.A., Solé, D., Sooronbaev, T., Spranger, O., Stelmach, R., Sterk, P.J., Sunyer, J., Thijs, C., To, T., Todo-Bom, A., Triggiani, M., Valenta, R., Valero, A.L., Valia, E., Valovirta, E., Van Ganse, E., van Hage, M., Vandenplas, O., Vasankari, T., Vellas, B., Vestbo, J., Vezzani, G., Vichyanond, P., Viegi, G., Vogelmeier, C., Vontetsianos, T., Wagenmann, M., Wallaert, B., Walker, S., Wang, D.Y., Wahn, U., Wickman, M., Williams, D.M., Williams, S., Wright, J., Yawn, B.P., Yiallouros, P.K., Yusuf, O.M., Zaidi, A., Zar, H.J., Zernotti, M.E., Zhang, L., Zhong, N., Zidarn, M., and Mercier, J.
- Abstract
This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause.
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- 2024
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8. Concepts for the Development of Person-Centered, Digitally Enabled, Artificial Intelligence-Assisted ARIA Care Pathways (ARIA 2024).
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Bousquet J, Schünemann HJ, Sousa-Pinto B, Zuberbier T, Togias A, Samolinski B, Bedbrook A, Czarlewski W, Hofmann-Apitius M, Litynska J, Vieira RJ, Anto JM, Fonseca JA, Brozek J, Bognanni A, Brussino L, Canonica GW, Cherrez-Ojeda I, Cruz AA, Vecillas LL, Dykewicz M, Gemicioglu B, Giovannini M, Haahtela T, Jacobs M, Jacomelli C, Klimek L, Kvedariene V, Larenas-Linnemann DE, Louis G, Lourenço O, Leemann L, Morais-Almeida M, Neves AL, Nadeau KC, Nowak A, Palamarchuk Y, Palkonen S, Papadopoulos NG, Parmelli E, Pereira AM, Pfaar O, Regateiro FS, Savouré M, Taborda-Barata L, Toppila-Salmi SK, Torres MJ, Valiulis A, Ventura MT, Williams S, Yepes-Nuñez JJ, Yorgancioglu A, Zhang L, Zuberbier J, Abdul Latiff AH, Abdullah B, Agache I, Al-Ahmad M, Al-Nesf MA, Al Shaikh NA, Amaral R, Ansotegui IJ, Asllani J, Balotro-Torres MC, Bergmann KC, Bernstein JA, Bindslev-Jensen C, Blaiss MS, Bonaglia C, Bonini M, Bossé I, Braido F, Caballero-Fonseca F, Camargos P, Carreiro-Martins P, Casale T, Castillo-Vizuete JA, Cecchi L, Teixeira MDC, Chang YS, Loureiro CC, Christoff G, Ciprandi G, Cirule I, Correia-de-Sousa J, Costa EM, Cvetkovski B, de Vries G, Del Giacco S, Devillier P, Dokic D, Douagui H, Durham SR, Enecilla ML, Fiocchi A, Fokkens WJ, Fontaine JF, Gawlik R, Gereda JE, Gil-Mata S, Giuliano AFM, Gotua M, Gradauskiene B, Guzman MA, Hossny E, Hrubiško M, Iinuma T, Irani C, Ispayeva Z, Ivancevich JC, Jartti T, Jeseňák M, Julge K, Jutel M, Kaidashev I, Bennoor KS, Khaltaev N, Kirenga B, Kraxner H, Kull I, Kulus M, Kuna P, Kupczyk M, Kurchenko A, La Grutta S, Lane S, Miculinic N, Lee SM, Le Thi Tuyet L, Lkhagvaa B, Louis R, Mahboub B, Makela M, Makris M, Maurer M, Melén E, Milenkovic B, Mohammad Y, Moniuszko M, Montefort S, Moreira A, Moreno P, Mullol J, Nadif R, Nakonechna A, Navarro-Locsin CG, Neffen HE, Nekam K, Niedoszytko M, Nunes E, Nyembue D, O'Hehir R, Ollert M, Ohta K, Okamoto Y, Okubo K, Olze H, Padukudru MA, Palomares O, Pali-Schöll I, Panzner P, Palosuo K, Park HS, Passalacqua G, Patella V, Pawankar R, Pétré B, Pitsios C, Plavec D, Popov TA, Puggioni F, Quirce S, Raciborski F, Ramonaité A, Recto M, Repka-Ramirez S, Roberts G, Robles-Velasco K, Roche N, Rodriguez-Gonzalez M, Romualdez JA, Rottem M, Rouadi PW, Salapatas M, Sastre J, Serpa FS, Sayah Z, Scichilone N, Senna G, Sisul JC, Solé D, Soto-Martinez ME, Sova M, Sozinova O, Stevanovic K, Ulrik CS, Szylling A, Tan FM, Tantilipikorn P, Todo-Bom A, Tomic-Spiric V, Tsaryk V, Tsiligianni I, Urrutia-Pereira M, Rostan MV, Sofiev M, Valovirta E, Van Eerd M, Van Ganse E, Vasankari T, Vichyanond P, Viegi G, Wallace D, Wang Y, Waserman S, Wong G, Worm M, Yusuf OM, Zaitoun F, and Zidarn M
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- Humans, Critical Pathways, Practice Guidelines as Topic, Patient-Centered Care, Asthma therapy, Artificial Intelligence, Rhinitis, Allergic therapy, Telemedicine
- Abstract
The traditional healthcare model is focused on diseases (medicine and natural science) and does not acknowledge patients' resources and abilities to be experts in their own lives based on their lived experiences. Improving healthcare safety, quality, and coordination, as well as quality of life, is an important aim in the care of patients with chronic conditions. Person-centered care needs to ensure that people's values and preferences guide clinical decisions. This paper reviews current knowledge to develop (1) digital care pathways for rhinitis and asthma multimorbidity and (2) digitally enabled, person-centered care.
1 It combines all relevant research evidence, including the so-called real-world evidence, with the ultimate goal to develop digitally enabled, patient-centered care. The paper includes (1) Allergic Rhinitis and its Impact on Asthma (ARIA), a 2-decade journey, (2) Grading of Recommendations, Assessment, Development and Evaluation (GRADE), the evidence-based model of guidelines in airway diseases, (3) mHealth impact on airway diseases, (4) From guidelines to digital care pathways, (5) Embedding Planetary Health, (6) Novel classification of rhinitis and asthma, (7) Embedding real-life data with population-based studies, (8) The ARIA-EAACI (European Academy of Allergy and Clinical Immunology) strategy for the management of airway diseases using digital biomarkers, (9) Artificial intelligence, (10) The development of digitally enabled, ARIA person-centered care, and (11) The political agenda. The ultimate goal is to propose ARIA 2024 guidelines centered around the patient to make them more applicable and sustainable., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)- Published
- 2024
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9. Molecular Pathways and Potential Therapeutic Targets of Refractory Asthma.
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Ishmael L, Casale T, and Cardet JC
- Abstract
Asthma is a chronic inflammatory lung disease. Refractory asthma poses a significant challenge in management due to its resistance to standard therapies. Key molecular pathways of refractory asthma include T2 inflammation mediated by Th2 and ILC2 cells, eosinophils, and cytokines including IL-4, IL-5, and IL-13. Additionally, non-T2 mechanisms involving neutrophils, macrophages, IL-1, IL-6, and IL-17 mediate a corticosteroid resistant phenotype. Mediators including alarmins (IL-25, IL-33, TSLP) and OX40L have overlap between T2 and non-T2 inflammation and may signify unique pathways of asthma inflammation. Therapies that target these pathways and mediators have proven to be effective in reducing exacerbations and improving lung function in subsets of severe asthma patients. However, there are patients with severe asthma who do not respond to approved therapies. Small molecule inhibitors, such as JAK-inhibitors, and monoclonal antibodies targeting mast cells, IL-1, IL-6, IL-33, TNFα, and OX40L are under investigation for their potential to modulate inflammation involved in refractory asthma. Understanding refractory asthma heterogeneity and identifying mediators involved are essential in developing therapeutic interventions for patients unresponsive to currently approved biologics. Further investigation is needed to develop personalized treatments based on these molecular insights to potentially offer more effective treatments for this complex disease.
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- 2024
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10. Asthma morbidity measures across Black ethnic subgroups.
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Ishmael L, Apter A, Busse PJ, Calderon-Candelario R, Carroll JK, Casale T, Celedón JC, Cohen R, Coyne-Beasley T, Cui J, Ericson B, Hernandez P, Kaelber DC, Maher N, Merriman C, Mosnaim G, Nazario S, Phipatanakul W, Pinto-Plata V, Riley I, Shenoy K, Wisnivesky J, Yawn B, Israel E, and Cardet JC
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- Adult, Humans, Emergency Service, Hospital statistics & numerical data, Ethnicity statistics & numerical data, Hispanic or Latino ethnology, Hispanic or Latino statistics & numerical data, Morbidity, Retrospective Studies, United States epidemiology, Puerto Rico ethnology, Black or African American ethnology, Black or African American statistics & numerical data, Caribbean People statistics & numerical data, Africa ethnology, Asthma complications, Asthma epidemiology, Asthma ethnology, Black People ethnology, Black People statistics & numerical data
- Abstract
Background: Black adults are disproportionately affected by asthma and are often considered a homogeneous group in research studies despite cultural and ancestral differences., Objective: We sought to determine if asthma morbidity differs across adults in Black ethnic subgroups., Methods: Adults with moderate-severe asthma were recruited across the continental United States and Puerto Rico for the PREPARE (PeRson EmPowered Asthma RElief) trial. Using self-identifications, we categorized multiethnic Black (ME/B) participants (n = 226) as Black Latinx participants (n = 146) or Caribbean, continental African, or other Black participants (n = 80). African American (AA/B) participants (n = 518) were categorized as Black participants who identified their ethnicity as being American. Baseline characteristics and retrospective asthma morbidity measures (self-reported exacerbations requiring systemic corticosteroids [SCs], emergency department/urgent care [ED/UC] visits, hospitalizations) were compared across subgroups using multivariable regression., Results: Compared with AA/B participants, ME/B participants were more likely to be younger, residing in the US Northeast, and Spanish speaking and to have lower body mass index, health literacy, and <1 comorbidity, but higher blood eosinophil counts. In a multivariable analysis, ME/B participants were significantly more likely to have ED/UC visits (incidence rate ratio [IRR] = 1.34, 95% CI = 1.04-1.72) and SC use (IRR = 1.27, 95% CI = 1.00-1.62) for asthma than AA/B participants. Of the ME/B subgroups, Puerto Rican Black Latinx participants (n = 120) were significantly more likely to have ED/UC visits (IRR = 1.64, 95% CI = 1.22-2.21) and SC use for asthma (IRR = 1.43, 95% CI = 1.06-1.92) than AA/B participants. There were no significant differences in hospitalizations for asthma among subgroups., Conclusions: ME/B adults, specifically Puerto Rican Black Latinx adults, have higher risk of ED/UC visits and SC use for asthma than other Black subgroups., (Copyright © 2023 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
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