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This book gives an overview of the current knowledge on the most common neurodegenerative diseases, including Alzheimer's disease, frontotemporal lobar degeneration, Lewy body dementia, Parkinson's disease, amyotrophic lateral sclerosis, and additional less common neurodegenerative diseases. Both clinical and basic aspects of each disease are treated, including novel diagnostic criteria, old and new treatments, basic discoveries (genetics, epigenetics and molecular biology), and translation of basic research into biomarkers for early diagnosis, particularly to identify peripheral biomarkers. “Neurodegenerative Disorders: From Pathogenesis to Clinical Approaches,” is aimed at clinicians, particularly those working in academic hospitals, and researchers in medical fields. Neurodegenerative diseases (NDs) are a heterogeneous group of complex diseases characterized by neuronal loss and progressive degeneration of different areas of the nervous system. NDs represent a significant health problem worldwide, with an increasing incidence rate. Although the exact pathogenesis of NDs remains unclear, a complex interaction among genetic, epigenetic, and environmental factors has been proposed. To date, no effective therapeutics have been developed to slow, halt, or prevent any NDs. Thus, information on the molecular mechanisms underlying the pathogenesis of NDs is strongly sought after. This book covers some major neurodegenerative diseases in detail along with diagnostic and immunological biomarkers. It also explores current therapeutic strategies and drug targets in common neurodegenerative diseases. This book is a suitable reference for all readers, including students, research scholars, and physicians who are interested in the mechanisms and treatment of neurodegenerative diseases. This book contains 17 chapters written by leading researchers in the field covering a broad range of topics related to thepathophysiology and possible clinical treatments for neurodegenerative disorders with advance drug therapy.

The book Neuroepigenetic Mechanisms in Health and Disease provides insight into mechanisms of epigenetic control, focusing on molecular, cellular and integrative aspects of neurobiology. Here, leading investigators in the field discuss in each chapter landmark scientific discoveries and recent advances in (neuro) epigenetics. Whereas some chapters concentrate in overviewing basic epigenetic mechanisms and the power of epigenome editing, other sections of the book discuss epigenetic control during learning and memory as well as in diverse brain related alterations, including neurodegenerative and rare neurologic diseases, and psychiatric disorders. In addition, the book covers relevant topics for modern human societies, including how drug abuse, environmental enrichment and meditation can influence brain function through epigenetic mechanisms. This book aims to serve as a useful source for junior scientists to first learn about the topic, as well as to more experienced researchers that seek for a broader view of this rapidly growing field that is beyond their area of specialization.

What would make this book unique is its focus on the fetal central nervous system (CNS) ultrasound, encompassing the wide range of CNS anomalies and the need for in-depth knowledge in fetal brain and spine normal anatomy and related abnormalities. From the anatomy and pathophysiology of the main CNS anomalies to the latest advancements in diagnostic techniques and therapeutic interventions, this book provides a thorough exploration of the subject matter.One of the key strengths of this book series lies in its structured approach. Each volume follows an organized framework, enabling readers to navigate through the content effortlessly. From the fundamentals of CNS ultrasound imaging to the intricacies of differential diagnosis, counseling and management of CNS anomalies, this book presents information in a logical and accessible manner. This structure not only facilitates comprehension but also allows readers to quickly locate specific topics and delve deeper into areas of interest.By creating this book, our aim is to fill a critical gap in the field of fetal medicine and ultrasound education. While numerous resources exist, this book stands out due to its comprehensive nature, covering both the theoretical foundations and practical applications of neurosonography. It also offers essential information for counseling and presents high-quality ultrasound images, enabling specialists to systematically and confidently approach normal CNS anatomy and accurately diagnose and manage CNS abnormalities, also exploring the role of additional imaging techniques, such as MRI, and genetic testing. This book bridges the divide between research and clinical practice, equipping healthcare professionals with the necessary knowledge and skills to provide optimal care for women throughout their reproductive lifespan. In conclusion, this book offers a resource for healthcare professionals, researchers, educators, and students in the field, bridging the gap between theory and practice and aiming to elevate the standard of care in fetal neurosonography.

This book explores the critical challenges and emerging trends in Information, Communication, and Computing Technology (ICCT). It provides a comprehensive overview of the key issues facing these rapidly evolving fields, from data security and privacy to advancements in artificial intelligence, communication networks, and quantum computing. Through in-depth analysis and expert perspectives, this volume aims to shed light on the complexities of ICCT and offer innovative solutions for researchers, practitioners, and students.Building on its exploration of challenges in ICCT, this book delves into several core areas. These include the development and deployment of secure and efficient communication networks, the ethical implications and technical hurdles of artificial intelligence and machine learning, and the promise and complexity of quantum computing. The book also addresses the management of big data, highlighting both its potential and the challenges of ensuring data privacy and security. Additionally, it examines the role of sustainability in computing, advocating for greener technologies and practices. The findings presented in this volume emphasize the need for interdisciplinary approaches and innovative thinking to address these challenges, offering insights that are both practical and forward-looking. This book is intended for a diverse audience that includes researchers, practitioners, and students in the fields of Information, Communication, and Computing Technology (ICCT). It is particularly valuable for academics and professionals seeking to deepen their understanding of current challenges and emerging trends in these areas. Additionally, policymakers, industry leaders, and technologists will find the book's insights useful for informing decisions and strategies in the development and implementation of advanced technologies. Whether you are a seasoned expert or a newcomer to the field, this book provides valuable perspectives that can enhance your knowledge and contribute to your work in ICCT.The Open Access version of this book, available at http://www.taylorfrancis.com, has been made available under a Creative Commons [Attribution-Non Commercial-No Derivatives (CC-BY-NC-ND)] 4.0 license.

The aim of this book is to cover the domain of craniofacial surgery focusing on neurological and neurosurgical issues. It will offer neurosurgeons and allied specialists a practical way to manage these complex and common malformations in a timely and appropriate way. At the same time, they will be provided the knowledge necessary to understand the functional aspects of these diseases, their anatomical and dynamic impact on the underlying cerebral and vascular structures as well as the cerebrospinal fluid pathways, to overcome the limits of the mere morphological and esthetical correction. Written by experts in the field, the book will represent a reference resource not only for pediatric neurosurgeons and plastic and reconstructive maxillofacial surgeons, but also for all neurosurgeons, residents, and fellows working in this area.

The medical humanities are becoming increasingly important as their first wave is interrogated by a critical approach that aims to uncover the wider possibilities of the field. In conversation with this debate, this volume explores the ways in which science fiction studies can contribute to such discussions. Science fiction challenges techno-optimism and offers a non-realist avenue for the expression of illness experience. Science fiction also estranges its readers from their societies and the medical possibilities inherent in those societies, inviting consideration of how medicine may be complicit with, or opposed to, other structures of power. By engaging these concerns, this Companion volume offers a unique viewpoint on the power of the future to shape the present.

Die 3. Auflage des Handbuchs bietet Klinikern, Laboratoriumsmedizinern, experimentell Forschenden sowie allen, die sich für den Liquor cerebrospinalis interessieren, in der täglichen Praxis eine schnelle und fundierte Orientierung über den aktuellen Wissensstand der Liquordiagnostik. Methoden und Indikationsstellungen zur Gewinnung des Liquor cerebrospinalis sowie die Analyseverfahren, Messparameter und Befundkonstellationen werden im Licht der neuesten Erkenntnisse ausführlich dargestellt. Das Buch ermöglicht eine umfassende Einsicht in methodische und interpretatorische Aspekte aller klinisch bedeutsamen Liquorparameter sowie in den Stellenwert der Liquordiagnostik heute. Neben den aktuellen Entwicklungen in Immunologie, Molekularbiologie und Proteinanalytik sowie der Standardisierung und Qualitätssicherung ist in der Neuauflage erstmals ein 50-seitiger Zytologieatlas mit exemplarischen Fallbeschreibungen Teil dieses Lehrbuches, welcher sich konzeptionell am stufenweisen Erfassen eines zytologischen Präparats orientiert und daher auch besonders für Einsteiger in die Liquorzytologie geeignet ist. Mit Unterstützung der Deutschen Gesellschaft für Liquordiagnostik und Klinische Neurochemie e.V. (DGLN).

As featured in SUNDAY TIMES MAGAZINE'controversial and courageous'– DAILY MAIL For years, we've been led to believe that depression is caused by a chemical imbalance in the brain and antidepressants are the solution. But what if this widely accepted belief has been built on unreliable truths? In Chemically Imbalanced, renowned psychiatrist Joanna Moncrieff takes readers on a thought-provoking journey through the history of the serotonin theory of depression, from its origins in the 1960s to its widespread acceptance in the 1990s. With clarity and compelling evidence, Moncrieff exposes how scientific understanding has been swayed by social and economic forces, leading to misconceptions that have shaped treatment decisions for millions. Accessible yet profoundly insightful, Chemically Imbalanced is essential reading for anyone seeking to make more informed choices about their mental health and understand the forces that shape the way we perceive and treat depression today.