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The development of dual‐mode organic photodetectors (OPDs) greatly improves its functionality by enabling selective spectral detection. This study presents a unidirectional bias‐switchable dual‐mode OPD that leverages selective carrier extraction through the manipulation of light field distributions and non‐equilibrium transport dynamics. This dual‐mode OPD features a simple single‐layer structure, allowing for straightforward one‐sided light incidence and without the need for voltage polarity switching. By optimizing the blend of poly(4‐butyl‐phenyl‐diphenyl‐amine) and non‐fullerene acceptor Y6, the device achieves efficient single‐band detection of ultraviolet (UV) light at low bias and dual‐band detection of UV and near‐infrared light at high bias. This versatility not only streamlines device architecture but also facilitates secure optical communication and gesture simulation, making it a valuable tool for advancing organic optoelectronics. The proposed strategy demonstrates universal applicability, paving the way for enhanced security and functionality in digital communication systems. [ABSTRACT FROM AUTHOR]

Enhancing carrier injection balance in near-infrared (NIR) to visible upconversion devices (UCDs) is crucial for improving efficiency and stability. This study presents the incorporation of an insulating polymer (polymethyl methacrylate (PMMA)) between an aluminum cathode and an electron transport layer to reduce excess electrons in a light-emitting layer, thus balancing electrode-injected electrons and NIR-generated holes. The optimized device achieved a fivefold increase in maximum luminance and upconversion efficiency compared to the control. Additionally, it demonstrated a fast optical response, a broad optical modulation range, and significant potential for bioimaging applications, achieving a maximum resolution of 1693 dpi. This approach provides an effective solution for enhancing carrier injection balance in UCDs.

Background: Riociguat is a novel soluble guanylate cyclase stimulator approved for the treatment of pulmonary arterial hypertension (PAH). Despite its widespread use, there has been a lack of large-scale studies assessing the adverse events (AEs) associated with this medication., Research Design and Methods: This study aimed to evaluate the AEs related to Riociguat by analyzing data from the FDA Adverse Event Reporting System (FAERS) from Q4 2013 to Q1 2024. A total of 12,149 AE reports were analyzed using four different disproportionality signal detection methodologies to identify significant AEs associated with Riociguat., Results: The analysis revealed 117 preferred terms (PTs) with significant disproportionality signals across all four methods. Among these, common AEs included 'headache,' 'dizziness,' 'hypotension,' 'nausea,' 'fall,' and 'loss of consciousness.' Notably, several unexpected AEs, such as 'fatigue,' 'malaise,' 'asthenia,' 'feeling abnormal,' and 'pain in extremity,' were identified, which were not highlighted in the product's package insert. Additionally, gender-specific differences were observed in certain adverse events., Conclusions: This study offers insights into Riociguat's side effects. Clinicians should monitor patients closely for unexpected symptoms like limb pain and fatigue, paying particular attention to male patients, as some AEs occur more frequently in this group.

It was recently revealed by Cabello in a theoretical Letter [Phys. Rev. Lett. 127, 070401 (2021)PRLTAO0031-900710.1103/PhysRevLett.127.070401] that nonlocality and contextuality, as two intuitively distinctive yet both critical quantum resources, can be surprisingly connected through Bell inequalities associated with state-independent contextuality sets. It provides a general unified method capable of converting contextuality into bipartite nonlocality. However, experimental tests of the inequalities are challenging and noise sensitive, and the requirements for the quantum states purity, dimensionality, and degree of entanglement have blocked the experimental implementation. We report a first experimental test of Cabello's inequalities from state-independent contextuality sets, by leveraging two-photon high-dimensional orbital angular momentum entangled states. Distinguishing from the standard single-particle ways, our experiment spotlights that the state-independent contextuality sets can be tested in a bipartite scenario, by which the "compatibility" or "sharpness" loopholes can be effectively avoided. Our results provide a new perspective and demonstrate the principle that contextuality, a widely used quantum resource, can be used in different physical scenarios.