9 results on '"Chen, Yan‐Hua"'
Search Results
2. Intestinal metaplasia in follow-up endoscopies among Asian patients with short-segment Barrett's esophagus: Regression, sampling error, and associated factors
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Lin, Kung-Hung, Liao, Jia-Bin, Chen, Yan-Hua, Wang, Huay-Min, Sun, Wei-Chih, Kao, Sung-Shuo, Tsai, Tzung-Jiun, Tsay, Feng-Woei, Tsai, Wei-Lun, Lee, Chao-Hsien, Chen, Wen-Chi, and Yu, Hsien-Chung
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- 2024
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3. Colonic crypt stem cell functions are controlled by tight junction protein claudin‐7 through Notch/Hippo signaling
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Naser, Amna N., primary, Xing, Tiaosi, additional, Tatum, Rodney, additional, Lu, Qun, additional, Boyer, Philip J., additional, and Chen, Yan‐Hua, additional
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- 2024
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4. Efficacy of Dan’e Fukang Soft Extract in Moderate Ovarian Hyperstimulation Syndrome for Concurrent Treatment of Blood and Fluid Guided by the “Triple Prevention” Principle
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Chen, Yan-Hua, primary, Zhang, Xue-Luo, additional, Li, Zhong-Yun, additional, Wang, Xian-Ping, additional, Wang, Jun, additional, Zhang, Zhi-Ping, additional, Zhu, Peng-Fei, additional, and Wu, Xue-Qing, additional
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- 2024
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5. Enabling Systemic Identification and Functionality Profiling for Cdc42 Homeostatic Modulators
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Malasala, Satyaveni, primary, Azimian, Fereshteh, additional, Chen, Yan-Hua, additional, Twiss, Jeffery L, additional, Boykin, Christi, additional, Nik Akhtar, Shayan, additional, and Lu, Qun, additional
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- 2024
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6. The climate change literacy of public officials in Taiwan: implications and strategies for global adaptation.
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Yeh, Shin-Cheng, Chen, Yan-Hua, Van Velzen, Ronald, and Lin, Pei-Hsuan
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Climate change literacy (CCL) is recognized as a critical component in formulating and implementing effective climate change policies and actions. However, the degree of CCL among those entrusted with these very responsibilities – public officials, remains relatively unexplored. This study pioneers an investigation into the CCL of public officials in Taiwan through a national survey. Our findings indicate that while a majority of these officials are cognizant of climate change issues, their personal commitment to climate action leaves considerable room for growth. Furthermore, their general understanding of climate change, its impacts, and the necessary adaptation strategies is found wanting. A similar deficit is observed in their comprehension of the relevance of the United Nations’ Sustainable Development Goals (SDGs) to climate change. Our study, by establishing a framework for assessing CCL among public officials and providing preliminary data on the CCL of Taiwanese officials, not only fills a significant knowledge gap but also lays the groundwork for comparative studies across nations. Moreover, our findings underscore the need for governments to invest in enhancing the CCL of their personnel, thereby equipping them with the requisite knowledge and motivation to contribute effectively to global climate change mitigation and adaptation efforts. [ABSTRACT FROM AUTHOR]
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- 2024
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7. Pain perception enhancement in consecutive second-eye phacoemulsification cataract surgeries under topical anesthesia.
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Luo JW, Chen YH, Yu JF, Chen YX, Ji M, and Guan HJ
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Cataract is the main cause of visual impairment and blindness worldwide while the only effective cure for cataract is still surgery. Consecutive phacoemulsification under topical anesthesia has been the routine procedure for cataract surgery. However, patients often grumbled that they felt more painful during the second-eye surgery compared to the first-eye surgery. The intraoperative pain experience has negative influence on satisfaction and willingness for second-eye cataract surgery of patients with bilateral cataracts. Intraoperative ocular pain is a complicated process induced by the nociceptors activation in the peripheral nervous system. Immunological, neuropsychological, and pharmacological factors work together in the enhancement of intraoperative pain. Accumulating published literatures have focused on the pain enhancement during the second-eye phacoemulsification surgeries. In this review, we searched PubMed database for articles associated with pain perception differences between consecutive cataract surgeries published up to Feb. 1, 2024. We summarized the recent research progress in mechanisms and interventions for pain perception enhancement in consecutive second-eye phacoemulsification cataract surgeries. This review aimed to provide novel insights into strategies for improving patients' intraoperative experience in second-eye cataract surgeries., Competing Interests: Conflicts of Interest: Luo JW, None; Chen YH, None; Yu JF, None; Chen YX, None; Ji M, None; Guan HJ, None., (International Journal of Ophthalmology Press.)
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- 2024
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8. [Effects of Controlled-release Blended Fertilizer on Crop Yield and Greenhouse Gas Emissions in Wheat-maize Rotation System].
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Gao W, Wang XX, Xie JZ, Chen YH, Ni XH, Wang JC, Dong YF, Li ZS, and Cao B
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- Fertilizers, Triticum, Zea mays, Delayed-Action Preparations, Nitrous Oxide analysis, Agriculture methods, Soil, China, Nitrogen, Urea, Greenhouse Gases
- Abstract
The increasing use of nitrogen fertilizers exerts extreme pressure on the environment (e.g., greenhouse gas emissions, GHGs) for winter wheat-summer maize rotation systems in the North China Plain. The application of controlled-release fertilizers is considered as an effective measure to improve crop yield and nitrogen fertilizer utilization efficiency. To explore the impact of one-time fertilization of controlled-release blended fertilizer on crop yield and GHGs of a wheat-maize rotation system, field experiments were carried out in Dezhou Modern Agricultural Science and Technology Park from 2020 to 2022. Five treatments were established for both winter wheat and summer maize, including no nitrogen control (CK), farmers' conventional nitrogen application (FFP), optimized nitrogen application (OPT), CRU1 (the blending ratio of coated urea and traditional urea on winter wheat and summer maize was 5:5 and 3:7, respectively), and CRU2 (the blending ratio of coated urea and traditional urea on winter wheat and summer maize was 7:3 and 5:5, respectively). The differences in yield, nitrogen fertilizer utilization efficiency, fertilization economic benefits, and GHGs among different treatments were compared and analyzed. The results showed that nitrogen application significantly increased the single season and annual crop yields of the wheat-maize rotation system ( P < 0.05). Compared with those of FFP, the CRU1 and CRU2 treatments increased the yields of summer maize by 0.4% to 5.6%, winter wheat by -5.4% to 4.1%, and annual yields by -1.1% to 3.9% ( P > 0.05). N recovery efficiency (NRE), N agronomic efficiency (NAE), and N partial factor productivity (NPFP) were increased by -8.6%-43.4%, 2.05-6.24 kg·kg
-1 , and 4.24-10.13 kg·kg-1 , respectively. Annual net income increased by 0.2% to 6.3%. Nitrogen application significantly increased the annual emissions of soil N2 O and CO2 in the rotation system ( P < 0.05) but had no effect on the annual emissions of CH4 (except for in the FFP treatment in the first year). The annual total N2 O emissions under the CRU1 and CRU2 treatments were significantly reduced by 23.4% to 30.2% compared to those under the FFP treatment ( P < 0.05). Additionally, nitrogen application significantly increased the annual global warming potential (GWP) of the rotation system ( P < 0.05), but the intensity of greenhouse gas emissions was reduced due to the increase in crop yields. Compared with that under FFP, the annual GWP under the CRU1 and CRU2 treatments decreased by 9.6% to 11.5% ( P < 0.05), and the annual GHGs decreased by 11.2% to 13.8% ( P > 0.05). In summary, the one-time application of controlled-release blended fertilizer had a positive role in improving crop yield and economic benefits, reducing nitrogen fertilizer input and labor costs, and GHGs, which is an effective nitrogen fertilizer management measure to promote cleaner production of food crops in the North China Plain.- Published
- 2024
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9. Enabling Systemic Identification and Functionality Profiling for Cdc42 Homeostatic Modulators.
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Malasala S, Azimian F, Chen YH, Twiss JL, Boykin C, Akhtar SN, and Lu Q
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Homeostatic modulation is pivotal in modern therapeutics. However, the discovery of bioactive materials to achieve this functionality is often random and unpredictive. Here, we enabled a systemic identification and functional classification of chemicals that elicit homeostatic modulation of signaling through Cdc42, a classical small GTPase of Ras superfamily. Rationally designed for high throughput screening, the capture of homeostatic modulators (HMs) along with molecular re-docking uncovered at least five functionally distinct classes of small molecules. This enabling led to partial agonists, hormetic agonists, bona fide activators and inhibitors, and ligand-enhanced agonists. Novel HMs exerted striking functionality in bradykinin-Cdc42 activation of actin remodelingand modified Alzheimer's disease-like behavior in mouse model. This concurrent computer-aided and experimentally empowered HM profiling highlights a model path for predicting HM landscape., One Sentence Summary: With concurrent experimental biochemical profiling and in silico computer-aided drug discovery (CADD) analysis, this study enabled a systemic identification and holistic classification of Cdc42 homeostatic modulators (HMs) and demonstrated the power of CADD to predict HM classes that can mimic the pharmacological functionality of interests., Introduction: Maintainingbody homeostasisis the ultimate keyto health. Thereare rich resources of bioactive materials for this functionality from both natural and synthetic chemical repertories including partial agonists (PAs) and various allosteric modulators. These homeostatic modulators (HMs) play a unique role in modern therapeutics for human diseases such as mental disorders and drug addiction. Buspirone, for example, acts as a PA for serotonin 5-HT
1A receptor but is an antagonist of the dopamine D2 receptor. Such medical useto treat general anxietydisorders (GADs) has become one of the most-commonly prescribed medications. However, most HMs in current uses target membrane proteins and are often derived from random discoveries. HMs as therapeutics targeting cytoplasmic proteins are even more rare despite that they are in paramount needs (e. g. targeting Ras superfamily small GTPases)., Rationale: Cdc42, a classical member of small GTPases of Ras superfamily, regulates PI3K-AKT and Raf-MEK-ERK pathways and has been implicated in various neuropsychiatric and mental disorders as well as addictive diseases and cancer. We previously reported the high-throughput in-silico screening followed by biological characterization of novel small molecule modulators (SMMs) of Cdc42-intersectin (ITSN) protein-protein interactions (PPIs). Based on a serendipitously discovered SMM ZCL278 with PA profile as a model compound, we hypothesized that there are more varieties of such HMs of Cdc42 signaling, and the model HMs can be defined by their distinct Cdc42-ITSN binding mechanisms using computer-aided drug discovery (CADD) analysis. We further reasoned that molecular modeling coupled with experimental profiling can predict HM spectrum and thus open the door for the holistic identification and classification of multifunctional cytoplasmic target-dependent HMs as therapeutics., Results: The originally discovered Cdc42 inhibitor ZCL278 displaying PA properties prompted the inquiry whether this finding represented a random encounter of PAs or whether biologically significant PAs can be widely present. The top ranked compounds were initially defined by structural fitness and binding scores to Cdc42. Because higher binding scores do not necessarily translate to higher functionality, we performed exhaustive experimentations with over 2,500 independent Cdc42-GEF (guanine nucleotide exchange factor) assays to profile the GTP loading activities on all 44 top ranked compounds derived from the SMM library. The N-MAR-GTP fluorophore-based Cdc42-GEF assay platform provided the first glimpse of the breadth of HMs. A spectrum of Cdc42 HMs was uncovered that can be categorized into five functionally distinct classes: Class I-partial competitive agonists, Class II-hormetic agonists, Class III- bona fide inhibitors (or inverse agonists), Class IV- bona fide activators or agonists, and Class V-ligand-enhanced agonists. Remarkably, model HMs such as ZCL278, ZCL279, and ZCL367 elicited striking biological functionality in bradykinin-Cdc42 activation of actin remodeling and modified Alzheimer's disease (AD)-like behavior in mouse model. Concurrently, we applied Schrödinger-enabled analyses to perform CADD predicted classification of Cdc42 HMs. We modified the classic molecular docking to instill a preferential binding pocket order (PBPO) of Cdc42-ITSN, which was based on the five binding pockets in interface of Cdc42-ITSN. We additionally applied a structure-based pharmacophore hypothesis generation for the model compounds. Then, using Schrödinger's Phase Shape, 3D ligand alignments assigned HMs to Class I, II, III, IV, and V compounds. In this HM library compounds, PBPO, matching pharmacophoric featuring, and shape alignment, all put ZCL993 in Class II compound category, which was confirmed in the Cdc42-GEF assay., Conclusion: HMs can target diseased cells or tissues while minimizing impacts on tissues that are unaffected. Using Cdc42 HM model compounds as a steppingstone, GTPase activation-based screening of SMM library uncovered five functionally distinct Cdc42 HM classes among which novel efficacies towards alleviating dysregulated AD-like features in mice were identified. Furthermore, molecular re-docking of HM model compounds led to the concept of PBPO. The CADD analysis with PBPO revealed similar profile in a color-coded spectrum to these five distinct classes of Cdc42 HMs identified by biochemical functionality-based screening. The current study enabled a systemic identification and holistic classification of Cdc42 HMs and demonstrated the power of CADD to predict an HM category that can mimic the pharmacological functionality of interests. With artificial intelligence/machine learning (AI/ML) on the horizon to mirror experimental pharmacological discovery like AlphaFold for protein structure prediction, our study highlights a model path to actively capture and profile HMs in potentially any PPI landscape., Identification and Functional Classification of Cdc42 Homeostatic Modulators Hms: Using Cdc42 HM model compounds as reference, GTPase activation-based screening of compound libraries uncovered five functionally distinct Cdc42 HM classes. HMs showed novel efficacies towards alleviating dysregulated Alzheimer's disease (AD)-like behavioral and molecular deficits. In parallel, molecular re-docking of HM model compounds established their preferential binding pocket orders (PBPO). PBPO-based profiling (Red reflects the most, whereas green reflects the least, preferable binding pocket) revealed trends of similar pattern to the five classes from the functionality-based classification.- Published
- 2024
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