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Background: Since diet is a known modulator of inflammation, the Dietary Inflammatory Index (DII), which quantifies the inflammatory potential of an individual's diet, becomes a significant parameter to consider. Chronic diarrhea is commonly linked to inflammatory processes within the gut. Thus, this study aimed to explore the potential link between DII and chronic diarrhea. Methods: This research utilized data from the National Health and Nutrition Examination Survey (NHANES) 2005–2010. The DII was calculated according to the average intake of 28 nutrients using information gathered from two 24-hour recall interviews. The Bristol Stool Form Scale (BSFS) was adopted to describe chronic diarrhea, identifying stool Type 6 and Type 7. Multivariate logistic regression models examined the causal connection between DII and chronic diarrhea. Additionally, subgroup analyses and interaction tests were conducted. Results: The study encompassed 11,219 adults, among whom 7.45% reported chronic diarrhea. Initially, multivariate logistic regression analysis revealed a positive association between DII and chronic diarrhea. Nevertheless, this connection lost statistical significance (OR = 1.00; 95% CI, 0.96–1.05; P = 0.8501) after adjusting for all confounding variables. Stratified by sex, the analysis revealed a notable rise in the risk of chronic diarrhea with increasing DII among female participants (all P for trend < 0.05). This tendency remained constant even after full adjustment (P for trend = 0.0192), whereas no significant association was noted in males (all P for trend > 0.05). Furthermore, an L-shaped association emerged between DII and chronic diarrhea, with an inflection point of -1.34. In the population with DII scores below -1.34, each unit increase in DII correlated with a 27% reduction in the probability of chronic diarrhea (OR = 0.73; 95% CI, 0.57–0.93), whereas in the population with DII scores above -1.34, the risk increased by 4% (OR = 1.04; 95% CI, 0.98–1.10). Merely, the gender interaction was shown to be statistically significant based on subgroup analyses and interaction tests. Conclusions: A favorable association between DII and chronic diarrhea exists in adults in the United States. Nevertheless, additional long-term prospective studies are required to confirm and solidify those findings. [ABSTRACT FROM AUTHOR]

Background: The consumption of trans fatty acids (TFAs) increases the risk of heart disease morbidity and mortality. However, the relationship between measurable indicators of TFAs and N-terminal pro-B-type natriuretic peptide (NT-proBNP) in general population remains unclear., Methods: 1478 adult participants with complete information on circulating TFA and NT-proBNP levels from National Health and Nutrition Examination Survey (NHANES) 1999-2000 were included in our cross-sectional survey. Smooth curve fitting, multivariable linear regression and binary logistic regression were performed to analyze the relationship between TFAs and NT-proBNP. We also conducted stratified analyses and interaction terms to explore the potential modifiers of the association., Results: Participants were grouped by quartiles of NT-proBNP levels. One-way ANOVA indicated significant differences in the plasma TFA concentrations across the groups. The smooth curve fitting diagram confirmed a significant linear relationship between TFAs and NT-proBNP. Multivariable linear regression analysis revealed that palmitelaidic acid, elaidic acid, vaccenic acid, linolelaidic acid and total TFAs was linearly and positively related to NT-proBNP. Stratified analyses and the interaction test showed that age, sex, and BMI did not affect the relation between them (P value for interaction >0.05). The results of binary logistic regression indicated that participants who were in higher quartiles of elaidic acid, vaccenic acid, linolelaidic acid and total TFAs showed a higher prevalence of elevated NT-proBNP., Conclusion: In a national sample of adults, circulating TFAs, regardless of their industrial or ruminant origin, were positively associated with NT-proBNP., Competing Interests: Declaration of competing interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2025. Published by Elsevier B.V.)