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1. Aperiodic (1/f) Neural Activity Robustly Tracks Symptom Severity Changes in Treatment-Resistant Depression

Author

Hacker, Carl, Mocchi, Madaline M., Xiao, Jiayang, Metzger, Brian, Adkinson, Joshua, Pascuzzi, Bailey, Mathura, Raissa, Oswalt, Denise, Watrous, Andrew, Bartoli, Eleonora, Allawala, Anusha, Pirtle, Victoria, Fan, Xiaoxu, Danstrom, Isabel, Shofty, Ben, Banks, Garrett, Zhang, Yue, Armenta-Salas, Michelle, Mirpour, Koorosh, Provenza, Nicole, Mathew, Sanjay, Cohn, Jeffrey F., Borton, David, Goodman, Wayne, Pouratian, Nader, Sheth, Sameer Anil, and Bijanki, Kelly R.

Abstract

A reliable physiological biomarker for major depressive disorder is essential for developing and optimizing neuromodulatory treatment paradigms. In this study, we investigated a passive electrophysiologic biomarker that tracks changes in depressive symptom severity on the order of minutes to hours.

Published
2025
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