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Your search keyword '"Colo, G."' showing total 3 results
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3 results on '"Colo, G."'

1. Electric dipole polarizability of $^{58}$Ni

Author

Brandherm, I., Bonaiti, F., von Neumann-Cosel, P., Bacca, S., Colò, G., Jansen, G. R., Li, Z. Z., Matsubara, H., Niu, Y. F., Reinhard, P. -G., Richter, A., Roca-Maza, X., and Tamii, A.

Subjects
Nuclear Experiment, Nuclear Theory
Abstract

The electric dipole strength distribution in $^{58}$Ni between 6 and 20 MeV has been determined from proton inelastic scattering experiments at very forward angles at RCNP, Osaka. The experimental data are rather well reproduced by quasiparticle random-phase approximation calculations including vibration coupling, despite a mild dependence on the adopted Skyrme interaction. They allow an estimate of the experimentally inaccessible high-energy contribution above 20 MeV, leading to an electric dipole polarizability $\alpha_\mathrm{D}(^{58}{\rm Ni}) = 3.48(31)$ fm$^3$. This serves as a test case for recent extensions of coupled-cluster calculations with chiral effective field theory interactions to nuclei with two nucleons on top of a closed-shell system., Comment: 8 pages, 4 figures

Published
2024

2. Gamma decay of the $^{154}$Sm Isovector Giant Dipole Resonance: Smekal-Raman Scattering as a Novel Probe of Nuclear Ground-State Deformation

Author

Kleemann, J., Pietralla, N., Friman-Gayer, U., Isaak, J., Papst, O., Prifti, K., Werner, V., Ayangeakaa, A. D., Beck, T., Colò, G., Cortés, M. L., Finch, S. W., Fulghieri, M., Gribble, D., Ide, K. E., James, X. K. -H., Janssens, R. V. F., Johnson, S. R., Koseoglou, P., Krishichayan, Savran, D., and Tornow, W.

Subjects
Nuclear Experiment, Nuclear Theory
Abstract

The $\gamma$ decays of the Isovector Giant Dipole Resonance (GDR) of the deformed nucleus $^{154}$Sm from $2^+_1$-Smekal-Raman and elastic scattering were measured using linearly polarized, quasi-monochromatic photon beams. The two scattering processes were disentangled through their distinct angular distributions. Their branching ratio and cross sections were determined at six excitation energies covering the $^{154}$Sm GDR. Both agree with the predictions of the geometrical model for the GDR and establish $\gamma$ decay as an observable sensitive to the structure of the resonance. Consequently, the data place strong constraints on the nuclear shape, including the degree of triaxiality. The derived $^{154}$Sm shape parameters $\beta=0.2926(26)$ and $\gamma=5.0(14)$ agree well with other measurements and recent Monte Carlo Shell-Model calculations., Comment: 7 pages, 3 figures, 3 tables

Published
2024

3. Early bone marrow alterations in patients with adenosine deaminase 2 deficiency across disease phenotypes and severities.

Author

Bulté D, Barzaghi F, Mesa-Nuñez C, Rigamonti C, Basso-Ricci L, Visconti C, Crippa S, Pettinato E, Gilioli D, Milani R, Quaranta P, Caorsi R, Cafaro A, Cangemi G, Lupia M, Schena F, Grossi A, Di Colo G, Federici S, Insalaco A, De Benedetti F, Marktel S, Di Micco R, Bernardo ME, Scala S, Cicalese MP, Conti F, Miano M, Gattorno M, Dufour C, Aiuti A, and Mortellaro A

Abstract

Background: Deficiency of adenosine deaminase 2 (DADA2) is a complex monogenic disease caused by recessive mutations in the ADA2 gene. DADA2 exhibits a broad clinical spectrum encompassing vasculitis, immunodeficiency, and hematologic abnormalities. Yet, the impact of DADA2 on the bone marrow (BM) microenvironment is largely unexplored., Objective: This study comprehensively examined the BM and peripheral blood of pediatric and adult patients with DADA2 presenting with rheumatologic/immunologic symptoms or severe hematologic manifestations., Methods: Immunophenotyping of hematopoietic stem cells (HSCs), progenitor cells, and mature cell populations was performed for 18 patients with DADA2. We also conducted a characterization of mesenchymal stromal cells., Results: Our study revealed a significant decrease in primitive HSCs and progenitor cells, alongside their reduced clonogenic capacity and multilineage differentiation potential. These BM defects were evident in patients with both severe and nonsevere hematologic manifestations, including pediatric patients, demonstrating that BM disruption can emerge silently and early on, even in patients who do not show obvious hematologic symptoms. Beyond stem cells, there was a reduction in mature cell populations in the BM and peripheral blood, affecting myeloid, erythroid, and lymphoid populations. Furthermore, BM mesenchymal stromal cells in patients with DADA2 exhibited reduced clonogenic and proliferation capabilities and were more prone to undergo cellular senescence marked by elevated DNA damage., Conclusions: Our exploration into the BM landscape of patients with DADA2 sheds light on the critical hematologic dimension of the disease and emphasizes the importance of vigilant monitoring, even in the case of subclinical presentation., Competing Interests: Disclosure statement This work received support from Fondazione Telethon (SR-Tiget Core Grant, Tele21-A5 and Tele21-E5) to A.M. and R.D.M., the Italian Ministry of Health (Progetto Ricerca Finalizzata 2019, RF-2019-12370600) to M.G., C.D., A.A., and A.M., PNRR 2022 (PNRR-MR1-2022-12376594) to F.B. and A.A., and the Else Kröner-Fresenius-Stiftung (EKFS) prize for Medical Research 2020 to A.A. R.D.M. is a New York Stem Cell FoundationRobertson Investigator. IRCCS San Raffaele Scientific Institute, IRCCS Istituto Giannina Gaslini, and IRCCS Bambino Gesù Children’s Hospital are part of the European Reference Network for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases, ERN-RITA (Project ID 739543). The centers involved are part of the Italian Pediatric Onco-Hematology Association (AIEOP). IRCCS San Raffaele Scientific Institute is part of the Inborn Error Working Party of the European Society for Blood and Marrow Transplantation (EBMT). Disclosure of potential conflict of interest: The authors declare that they have no relevant conflicts of interest., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)

Published
2024
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