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Your search keyword '"Das, Gaurav"' showing total 13 results
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13 results on '"Das, Gaurav"'

11. Breast cancer survival in India across 11 geographic areas under the National Cancer Registry Programme

Author

Sathishkumar, Krishnan, primary, Sankarapillai, Jayasankar, additional, Mathew, Aleyamma, additional, Nair, Rekha A., additional, Gangane, Nitin, additional, Khuraijam, Sushma, additional, Barmon, Debabrata, additional, Pandya, Shashank, additional, Majumdar, Gautam, additional, Deshmane, Vinay, additional, Zomawia, Eric, additional, Bhutia, Tseten Wangyal, additional, Jerang, Kaling, additional, George, Preethi Sara, additional, Maliye, Swapna, additional, Laishram, Rajesh, additional, Das, Gaurav, additional, Shah, Anand, additional, Debbarma, Shiromani, additional, Koyande, Shravani, additional, Pachuau, Lalawmpuii, additional, Sherpa, Ashok, additional, Jongkey, Gegong, additional, Chaturvedi, Meesha, additional, Das, Priyanka, additional, Santhappan, Stephen, additional, and Mathur, Prashant, additional

Published
2024
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12. Extracellular Matrix (ECM)-Mimicking Neuroprotective Injectable Sulfo-Functionalized Peptide Hydrogel for Repairing Brain Injury

Author

Adak, Anindyasundar, Das, Gaurav, Khan, Juhee, Mukherjee, Nabanita, Gupta, Varsha, Mallesh, Rathnam, and Ghosh, Surajit

Abstract

Brain injury can lead to the loss of neuronal functions and connections, along with the damage of the extracellular matrix (ECM). Thus, it ultimately results in devastating long-term damage, and recovery from this damage is a challenging task. To address this issue, we have designed a sulfo-group-functionalized injectable biocompatible peptide hydrogel, which not only mimics the ECM and supports the damaged neurons but also releases a neurotrophic factor around the injured sites of the brain in the presence of the matrix metalloproteinase 9 (MMP9) enzyme. It has also been observed that the driving force of hydrogel formation is a β-sheet secondary structure and π–π stacking interactions between Phe-Phe moieties. The hydrogel is able not only to promote neurite outgrowth of PC12-derived neurons and primary neurons cultured in its presence but also to nullify the toxic effects of anti-nerve growth factor (Anti-NGF)-induced neurons. It also promotes the expression of vital neuronal markers in rat cortical primary neurons, displays substantial potential in neuroregeneration, and also promotes fast recovery of the sham injured mice brain. Increased expression of reactive astrocytes in the hippocampal dentate gyrus region of the sham injured brain clearly suggests its tremendous ability in the neural repair of the damaged brain. Thus, we can convincingly state that our hydrogel is capable of repairing brain injury by mimicking an ECM-like environment and providing neuroprotection to the damaged neurons.

Published
2024
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13. Porous Organic Polymer-Based Nanocomposites for Hypoxia Relieving and Enhanced Chemotherapy in Hepatocellular Carcinoma.

Author

Mukherjee P, Guha S, Ghosh A, Kar K, Das G, and Sahu SK

Abstract

Uncontrolled proliferation and altered metabolism of cancer cells result in an imbalance of nutrients and oxygen supply, and persuade hypoxia. Hypoxia, in turn, activates the transcription gene HIF-1α, which eventually upregulates the efflux transporter P-gp and induces multidrug resistance (MDR). Thus, hypoxia leads to the development of resistance to conventional therapies. Therefore, the fabrication of a nanoscale porous system enriched with upconversion nanoparticles to target cancer cells, evade hypoxia, and enhance anticancer therapy is the key goal of this article. Herein, upconversion nanoparticles are embedded in a nanoscale porous organic polymer (POP) and further conjugated with a targeting moiety and a catalase molecule. The nanoscale POP embedded in UCNPs is generated at room temperature. The targeting ligand, lactobionic acid, is attached after polymer coating, which effectively targets liver cancer cells. Then, catalase is grafted effectively to produce oxygen. Endogenously generated oxygen alleviates hypoxia in liver cancer cells. The drug- and catalase-loaded composite exhibit greater cytotoxicity in hypoxic liver cells than in normal cells by overcoming hypoxia and downregulating the hypoxia-inducible factors.

Published
2024
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